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'Disinhibition And Apathy' after SSRI Use In Youths, article link

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'E. Jane Garland, M.D., clinical associate professor of psychiatry and

A. Baerg, M.D., clinical assistant professor of psychiatry at

the University of British Columbia's Children's Hospital in Vancouver,

Canada, report on five patients with dose-dependent, reversible frontal

lobe (amotivational) syndrome characterized by delayed onset after

treatment with fluoxetine and paroxetine, two selective serotonin

reuptake inhibitors (SSRIs) commonly prescribed to treat adolescent

depression.

A frontal lobe syndrome characterized by apathy, indifference, loss of

initiative and/or disinhibition has developed in some adults during

SSRI therapy but has not been previously reported in the pediatric

population (Hoehn-Saric et al. 1990). In each case the patient had a

significant change in behavior, which included becoming indifferent

toward work performance, exhibiting impulsive and disinhibited

behavior, or developing poor concentration and forgetful behavior

(Hoehn-Saric et al. 1991). '

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'E. Jane Garland, M.D., clinical associate professor of psychiatry and

A. Baerg, M.D., clinical assistant professor of psychiatry at

the University of British Columbia's Children's Hospital in Vancouver,

Canada, report on five patients with dose-dependent, reversible frontal

lobe (amotivational) syndrome characterized by delayed onset after

treatment with fluoxetine and paroxetine, two selective serotonin

reuptake inhibitors (SSRIs) commonly prescribed to treat adolescent

depression.

A frontal lobe syndrome characterized by apathy, indifference, loss of

initiative and/or disinhibition has developed in some adults during

SSRI therapy but has not been previously reported in the pediatric

population (Hoehn-Saric et al. 1990). In each case the patient had a

significant change in behavior, which included becoming indifferent

toward work performance, exhibiting impulsive and disinhibited

behavior, or developing poor concentration and forgetful behavior

(Hoehn-Saric et al. 1991). '

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'E. Jane Garland, M.D., clinical associate professor of psychiatry and

A. Baerg, M.D., clinical assistant professor of psychiatry at

the University of British Columbia's Children's Hospital in Vancouver,

Canada, report on five patients with dose-dependent, reversible frontal

lobe (amotivational) syndrome characterized by delayed onset after

treatment with fluoxetine and paroxetine, two selective serotonin

reuptake inhibitors (SSRIs) commonly prescribed to treat adolescent

depression.

A frontal lobe syndrome characterized by apathy, indifference, loss of

initiative and/or disinhibition has developed in some adults during

SSRI therapy but has not been previously reported in the pediatric

population (Hoehn-Saric et al. 1990). In each case the patient had a

significant change in behavior, which included becoming indifferent

toward work performance, exhibiting impulsive and disinhibited

behavior, or developing poor concentration and forgetful behavior

(Hoehn-Saric et al. 1991). '

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Share on other sites

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'E. Jane Garland, M.D., clinical associate professor of psychiatry and

A. Baerg, M.D., clinical assistant professor of psychiatry at

the University of British Columbia's Children's Hospital in Vancouver,

Canada, report on five patients with dose-dependent, reversible frontal

lobe (amotivational) syndrome characterized by delayed onset after

treatment with fluoxetine and paroxetine, two selective serotonin

reuptake inhibitors (SSRIs) commonly prescribed to treat adolescent

depression.

A frontal lobe syndrome characterized by apathy, indifference, loss of

initiative and/or disinhibition has developed in some adults during

SSRI therapy but has not been previously reported in the pediatric

population (Hoehn-Saric et al. 1990). In each case the patient had a

significant change in behavior, which included becoming indifferent

toward work performance, exhibiting impulsive and disinhibited

behavior, or developing poor concentration and forgetful behavior

(Hoehn-Saric et al. 1991). '

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