A.Ds And Male Fertility Article Link...

[Guest guest]

http://wsunews.wsu.edu/detail.asp?StoryID=3497

Study on Antidepressants and Male Fertility Generates International

Interest

SPOKANE, Wash. -- A Spokane study evaluating the effect of selective

serotonin reuptake inhibitors (such as Prozac and Celexa) on sperm

DNA integrity has generated international interest, according to

Joanna Ellington and e St. Dennis of Washington State University

Spokane, the study's lead investigators.

" We are currently receiving e-mail from all around the world from

couples who have had trouble conceiving while the male partner has

been on SSRI antidepressants. Based on our preliminary data, several

individuals have gone ahead and sent in sperm samples to study

collaborator Dr. Don Evenson for the sperm chromatin analysis, which

determines the level of damaged DNA in sperm, " states

Ellington. " Several men in this anecdotal group have had high levels

of chromatin damage which decreased by approximately one half once

they were no longer on the medication. "

Sperm DNA damage is critical because it has been correlated with

fertilization failure, miscarriages of pregnancies, and even

childhood diseases. In fact, sperm DNA damage from smoking has been

cited as causing a fourfold increase in levels of childhood cancer.

Likewise, according to Dr. Evenson, recent data suggest that more

than 50% of the time couples with a history of repeated miscarriage

may be struggling with sperm DNA damage problems.

It is currently known that chemotherapy drugs and environmental

toxins can cause sperm chromatin damage. However, the possible role

of more commonly used pharmaceutical agents has not been well

studied. More than 3 million men of reproductive age are currently

taking SSRIs for depression. In order to confirm or deny their

hypothesis of a link between SSRI therapy and sperm DNA damage,

Ellington and St. Dennis are asking men with depression to

participate in the study. In particular, they are looking for men who

are thinking about beginning antidepressant medications, so they can

look at sperm DNA before and after medication.

Participants will receive monthly depression monitoring, detailed

sperm analysis including DNA damage monitoring, and up to $300 of

cash for participation. Ellington says, " We are eager to complete

study enrollment as soon as possible, to reject or accept our

hypothesis, as we feel that this is an issue of critical public

health importance. "

Men interested in participating in the study may call (509) 358-7637

for information. The study will continue over the course of two years.

News release on study's NIH funding: wsunews.wsu.edu/detail.asp?

StoryID=3039 (May 13, 2002)

[Guest guest]

http://wsunews.wsu.edu/detail.asp?StoryID=3497

Study on Antidepressants and Male Fertility Generates International

Interest

SPOKANE, Wash. -- A Spokane study evaluating the effect of selective

serotonin reuptake inhibitors (such as Prozac and Celexa) on sperm

DNA integrity has generated international interest, according to

Joanna Ellington and e St. Dennis of Washington State University

Spokane, the study's lead investigators.

" We are currently receiving e-mail from all around the world from

couples who have had trouble conceiving while the male partner has

been on SSRI antidepressants. Based on our preliminary data, several

individuals have gone ahead and sent in sperm samples to study

collaborator Dr. Don Evenson for the sperm chromatin analysis, which

determines the level of damaged DNA in sperm, " states

Ellington. " Several men in this anecdotal group have had high levels

of chromatin damage which decreased by approximately one half once

they were no longer on the medication. "

Sperm DNA damage is critical because it has been correlated with

fertilization failure, miscarriages of pregnancies, and even

childhood diseases. In fact, sperm DNA damage from smoking has been

cited as causing a fourfold increase in levels of childhood cancer.

Likewise, according to Dr. Evenson, recent data suggest that more

than 50% of the time couples with a history of repeated miscarriage

may be struggling with sperm DNA damage problems.

It is currently known that chemotherapy drugs and environmental

toxins can cause sperm chromatin damage. However, the possible role

of more commonly used pharmaceutical agents has not been well

studied. More than 3 million men of reproductive age are currently

taking SSRIs for depression. In order to confirm or deny their

hypothesis of a link between SSRI therapy and sperm DNA damage,

Ellington and St. Dennis are asking men with depression to

participate in the study. In particular, they are looking for men who

are thinking about beginning antidepressant medications, so they can

look at sperm DNA before and after medication.

Participants will receive monthly depression monitoring, detailed

sperm analysis including DNA damage monitoring, and up to $300 of

cash for participation. Ellington says, " We are eager to complete

study enrollment as soon as possible, to reject or accept our

hypothesis, as we feel that this is an issue of critical public

health importance. "

Men interested in participating in the study may call (509) 358-7637

for information. The study will continue over the course of two years.

News release on study's NIH funding: wsunews.wsu.edu/detail.asp?

StoryID=3039 (May 13, 2002)

[Guest guest]

http://wsunews.wsu.edu/detail.asp?StoryID=3497

Study on Antidepressants and Male Fertility Generates International

Interest

SPOKANE, Wash. -- A Spokane study evaluating the effect of selective

serotonin reuptake inhibitors (such as Prozac and Celexa) on sperm

DNA integrity has generated international interest, according to

Joanna Ellington and e St. Dennis of Washington State University

Spokane, the study's lead investigators.

" We are currently receiving e-mail from all around the world from

couples who have had trouble conceiving while the male partner has

been on SSRI antidepressants. Based on our preliminary data, several

individuals have gone ahead and sent in sperm samples to study

collaborator Dr. Don Evenson for the sperm chromatin analysis, which

determines the level of damaged DNA in sperm, " states

Ellington. " Several men in this anecdotal group have had high levels

of chromatin damage which decreased by approximately one half once

they were no longer on the medication. "

Sperm DNA damage is critical because it has been correlated with

fertilization failure, miscarriages of pregnancies, and even

childhood diseases. In fact, sperm DNA damage from smoking has been

cited as causing a fourfold increase in levels of childhood cancer.

Likewise, according to Dr. Evenson, recent data suggest that more

than 50% of the time couples with a history of repeated miscarriage

may be struggling with sperm DNA damage problems.

It is currently known that chemotherapy drugs and environmental

toxins can cause sperm chromatin damage. However, the possible role

of more commonly used pharmaceutical agents has not been well

studied. More than 3 million men of reproductive age are currently

taking SSRIs for depression. In order to confirm or deny their

hypothesis of a link between SSRI therapy and sperm DNA damage,

Ellington and St. Dennis are asking men with depression to

participate in the study. In particular, they are looking for men who

are thinking about beginning antidepressant medications, so they can

look at sperm DNA before and after medication.

Participants will receive monthly depression monitoring, detailed

sperm analysis including DNA damage monitoring, and up to $300 of

cash for participation. Ellington says, " We are eager to complete

study enrollment as soon as possible, to reject or accept our

hypothesis, as we feel that this is an issue of critical public

health importance. "

Men interested in participating in the study may call (509) 358-7637

for information. The study will continue over the course of two years.

News release on study's NIH funding: wsunews.wsu.edu/detail.asp?

StoryID=3039 (May 13, 2002)

[Guest guest]

http://wsunews.wsu.edu/detail.asp?StoryID=3497

Study on Antidepressants and Male Fertility Generates International

Interest

SPOKANE, Wash. -- A Spokane study evaluating the effect of selective

serotonin reuptake inhibitors (such as Prozac and Celexa) on sperm

DNA integrity has generated international interest, according to

Joanna Ellington and e St. Dennis of Washington State University

Spokane, the study's lead investigators.

" We are currently receiving e-mail from all around the world from

couples who have had trouble conceiving while the male partner has

been on SSRI antidepressants. Based on our preliminary data, several

individuals have gone ahead and sent in sperm samples to study

collaborator Dr. Don Evenson for the sperm chromatin analysis, which

determines the level of damaged DNA in sperm, " states

Ellington. " Several men in this anecdotal group have had high levels

of chromatin damage which decreased by approximately one half once

they were no longer on the medication. "

Sperm DNA damage is critical because it has been correlated with

fertilization failure, miscarriages of pregnancies, and even

childhood diseases. In fact, sperm DNA damage from smoking has been

cited as causing a fourfold increase in levels of childhood cancer.

Likewise, according to Dr. Evenson, recent data suggest that more

than 50% of the time couples with a history of repeated miscarriage

may be struggling with sperm DNA damage problems.

It is currently known that chemotherapy drugs and environmental

toxins can cause sperm chromatin damage. However, the possible role

of more commonly used pharmaceutical agents has not been well

studied. More than 3 million men of reproductive age are currently

taking SSRIs for depression. In order to confirm or deny their

hypothesis of a link between SSRI therapy and sperm DNA damage,

Ellington and St. Dennis are asking men with depression to

participate in the study. In particular, they are looking for men who

are thinking about beginning antidepressant medications, so they can

look at sperm DNA before and after medication.

Participants will receive monthly depression monitoring, detailed

sperm analysis including DNA damage monitoring, and up to $300 of

cash for participation. Ellington says, " We are eager to complete

study enrollment as soon as possible, to reject or accept our

hypothesis, as we feel that this is an issue of critical public

health importance. "

Men interested in participating in the study may call (509) 358-7637

for information. The study will continue over the course of two years.

News release on study's NIH funding: wsunews.wsu.edu/detail.asp?

StoryID=3039 (May 13, 2002)