what's next for SSRI's ? ..........SSRI & C-reactive protein levels ... mmmmmmmm

[Guest guest]

The British Journal of Psychiatry (2006) 188: 449-452. doi:

10.1192/bjp.bp.105.011015

© 2006 The Royal College of Psychiatrists

This Article

Antidepressant therapy and C-reactive protein levels

SINEAD M. O'BRIEN, MRCPsych, LUCINDA V. SCOTT, PhD, MRCPsych and

TIMOTHY G. DINAN, MD, PhD, MRCPsych

Department of Psychiatry and Alimentary Pharmabiotic Centre,

University College Cork, Ireland

Correspondence: Professor Ted Dinan, Department of Psychiatry, Cork

University Hospital, Wilton, Cork, Ireland. Tel: +353 21 4920119; e-

mail: t.dinan@...

Declaration of interest T.G.D. has lectured at meetings sponsored by

or acted as an advisor to all companies who market a branded SSRI.

Background Major depression is associated with activation of the

inflammatory response.

Aims To examine C-reactive protein levels in depression and to

determine the impact of selective serotonin reuptake inhibitor

(SSRI) therapy.

Method Atwo-part study. In study 1, which used a between-subjects

design, C-reactive protein was measured in 32 patients (20 currently

depressed, 12 euthymic) with a history of DSM–IV major depression,

all of whom were treated with an SSRI, and in a healthy comparison

group (n=20). Study 2 employed a within-subject design: C-reactive

protein was measured in 20 patients with major depression both

before and after SSRI treatment.

Results In study 1, C-reactive protein levels did not differ between

the group with depressive disorder (either currently depressed or

euthymic) treated with SSRIs and the healthy group.In study 2 the

protein levels dropped significantly following treatment with

antidepressant medication.

Conclusions Following SSRI treatment for major depression there is a

significant drop in C-reactive protein concentrations whether or not

the depression resolves. These findings indicate that antidepress-

ants induce an anti-inflammatory response independent of

antidepressant action.

Related articles in BJP:

Highlights of this issue

SUKHWINDER S. SHERGILL

BJP 2006 188: 401. [Full Text]

---------------------------------------------------------------------

-----------

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych

Journals

Copyright © 2006 The Royal College of Psychiatrists.

[Guest guest]

The British Journal of Psychiatry (2006) 188: 449-452. doi:

10.1192/bjp.bp.105.011015

© 2006 The Royal College of Psychiatrists

This Article

Antidepressant therapy and C-reactive protein levels

SINEAD M. O'BRIEN, MRCPsych, LUCINDA V. SCOTT, PhD, MRCPsych and

TIMOTHY G. DINAN, MD, PhD, MRCPsych

Department of Psychiatry and Alimentary Pharmabiotic Centre,

University College Cork, Ireland

Correspondence: Professor Ted Dinan, Department of Psychiatry, Cork

University Hospital, Wilton, Cork, Ireland. Tel: +353 21 4920119; e-

mail: t.dinan@...

Declaration of interest T.G.D. has lectured at meetings sponsored by

or acted as an advisor to all companies who market a branded SSRI.

Background Major depression is associated with activation of the

inflammatory response.

Aims To examine C-reactive protein levels in depression and to

determine the impact of selective serotonin reuptake inhibitor

(SSRI) therapy.

Method Atwo-part study. In study 1, which used a between-subjects

design, C-reactive protein was measured in 32 patients (20 currently

depressed, 12 euthymic) with a history of DSM–IV major depression,

all of whom were treated with an SSRI, and in a healthy comparison

group (n=20). Study 2 employed a within-subject design: C-reactive

protein was measured in 20 patients with major depression both

before and after SSRI treatment.

Results In study 1, C-reactive protein levels did not differ between

the group with depressive disorder (either currently depressed or

euthymic) treated with SSRIs and the healthy group.In study 2 the

protein levels dropped significantly following treatment with

antidepressant medication.

Conclusions Following SSRI treatment for major depression there is a

significant drop in C-reactive protein concentrations whether or not

the depression resolves. These findings indicate that antidepress-

ants induce an anti-inflammatory response independent of

antidepressant action.

Related articles in BJP:

Highlights of this issue

SUKHWINDER S. SHERGILL

BJP 2006 188: 401. [Full Text]

---------------------------------------------------------------------

-----------

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych

Journals

Copyright © 2006 The Royal College of Psychiatrists.

[Guest guest]

The British Journal of Psychiatry (2006) 188: 449-452. doi:

10.1192/bjp.bp.105.011015

© 2006 The Royal College of Psychiatrists

This Article

Antidepressant therapy and C-reactive protein levels

SINEAD M. O'BRIEN, MRCPsych, LUCINDA V. SCOTT, PhD, MRCPsych and

TIMOTHY G. DINAN, MD, PhD, MRCPsych

Department of Psychiatry and Alimentary Pharmabiotic Centre,

University College Cork, Ireland

Correspondence: Professor Ted Dinan, Department of Psychiatry, Cork

University Hospital, Wilton, Cork, Ireland. Tel: +353 21 4920119; e-

mail: t.dinan@...

Declaration of interest T.G.D. has lectured at meetings sponsored by

or acted as an advisor to all companies who market a branded SSRI.

Background Major depression is associated with activation of the

inflammatory response.

Aims To examine C-reactive protein levels in depression and to

determine the impact of selective serotonin reuptake inhibitor

(SSRI) therapy.

Method Atwo-part study. In study 1, which used a between-subjects

design, C-reactive protein was measured in 32 patients (20 currently

depressed, 12 euthymic) with a history of DSM–IV major depression,

all of whom were treated with an SSRI, and in a healthy comparison

group (n=20). Study 2 employed a within-subject design: C-reactive

protein was measured in 20 patients with major depression both

before and after SSRI treatment.

Results In study 1, C-reactive protein levels did not differ between

the group with depressive disorder (either currently depressed or

euthymic) treated with SSRIs and the healthy group.In study 2 the

protein levels dropped significantly following treatment with

antidepressant medication.

Conclusions Following SSRI treatment for major depression there is a

significant drop in C-reactive protein concentrations whether or not

the depression resolves. These findings indicate that antidepress-

ants induce an anti-inflammatory response independent of

antidepressant action.

Related articles in BJP:

Highlights of this issue

SUKHWINDER S. SHERGILL

BJP 2006 188: 401. [Full Text]

---------------------------------------------------------------------

-----------

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych

Journals

Copyright © 2006 The Royal College of Psychiatrists.

[Guest guest]

The British Journal of Psychiatry (2006) 188: 449-452. doi:

10.1192/bjp.bp.105.011015

© 2006 The Royal College of Psychiatrists

This Article

Antidepressant therapy and C-reactive protein levels

SINEAD M. O'BRIEN, MRCPsych, LUCINDA V. SCOTT, PhD, MRCPsych and

TIMOTHY G. DINAN, MD, PhD, MRCPsych

Department of Psychiatry and Alimentary Pharmabiotic Centre,

University College Cork, Ireland

Correspondence: Professor Ted Dinan, Department of Psychiatry, Cork

University Hospital, Wilton, Cork, Ireland. Tel: +353 21 4920119; e-

mail: t.dinan@...

Declaration of interest T.G.D. has lectured at meetings sponsored by

or acted as an advisor to all companies who market a branded SSRI.

Background Major depression is associated with activation of the

inflammatory response.

Aims To examine C-reactive protein levels in depression and to

determine the impact of selective serotonin reuptake inhibitor

(SSRI) therapy.

Method Atwo-part study. In study 1, which used a between-subjects

design, C-reactive protein was measured in 32 patients (20 currently

depressed, 12 euthymic) with a history of DSM–IV major depression,

all of whom were treated with an SSRI, and in a healthy comparison

group (n=20). Study 2 employed a within-subject design: C-reactive

protein was measured in 20 patients with major depression both

before and after SSRI treatment.

Results In study 1, C-reactive protein levels did not differ between

the group with depressive disorder (either currently depressed or

euthymic) treated with SSRIs and the healthy group.In study 2 the

protein levels dropped significantly following treatment with

antidepressant medication.

Conclusions Following SSRI treatment for major depression there is a

significant drop in C-reactive protein concentrations whether or not

the depression resolves. These findings indicate that antidepress-

ants induce an anti-inflammatory response independent of

antidepressant action.

Related articles in BJP:

Highlights of this issue

SUKHWINDER S. SHERGILL

BJP 2006 188: 401. [Full Text]

---------------------------------------------------------------------

-----------

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych

Journals

Copyright © 2006 The Royal College of Psychiatrists.