Antidepressants Find Way to Newborn Lungs

[Guest guest]

http://www.medpagetoday.com/OBGYN/Pregnancy/tb/2639

Antidepressants Find Way to Newborn Lungs

By Judith Groch, MedPage Today Staff Writer

Reviewed by Zalman S. Agus, MD; Emeritus Professor at the University of

Pennsylvania School of Medicine.

February 08, 2006

Be aware that in this study the risk of persistent pulmonary pulmonary

hypertension in the newborn (PPHN) is elevated only among women who took

selective serotonin reuptake inhibitors (SSRIs) after the 20th week of

pregnancy.

Explain to patients that other non-SSRI antidepressants had no effect on the

lung disorder.

Although the risk of PPHN is increased five- to sixfold with the use of

SSRIs, only 1% of women taking the drug will have a newborn with PPHN. Thus,

consider with patients both the benefits of SSRIs in the treatment of

depression and the potential risk of PPHN relative to the risks and benefits

of alternative treatments or nontreatment.

Review

SAN DIEGO - Selective serotonin reuptake inhibitors (SSRIs) used late in

pregnancy have been linked to a risk of persistent pulmonary hypertension in

the newborn.

A case-control study found that infants of women who took an SSRI after the

20 weeks of gestation had six times the risk of the lung disorder compared

with babies born of drug-free women, reported D. Chambers, Ph.D.,

M.P.H., of the University of California here and colleagues in the Feb. 9

issue of the New England Journal of Medicine.

The researchers recruited 377 women whose babies had persistent pulmonary

hypertension of the newborn (PPHN) and compared them with 836 matched

controls.

At the end of the 20th week of gestation, 14 infants with the lung disorder

had been exposed to an SSRI compared with only six control infants (adjusted

odds ratio 6.1, 95% CI, 2.2-16.8), the team reported.

Timing and drug type were specific. Neither the use of an SSRI before the

20th week of gestation nor use of non-SSRI antidepressants at any time

during pregnancy was associated with an increased risk of the infant lung

disorder.

The report comes on the heels of two earlier antidepressant studies with

troubling news for pregnant women with major depression. Israeli researchers

found SSRI use linked to neonatal withdrawal syndrome, while Massachusetts

General researchers reported a greater risk of relapse for severely

depressed women who stopped using the drugs during pregnancy.

In the UCSD study, maternal interviews were conducted by nurses who were

blinded to the study hypothesis and potential confounders, including

demographic variables and health history, the researchers said.

Describing the possible biological mechanisms for the effect, the authors

wrote that the lung acts as a reservoir for antidepressants. They suggest

that serotonin may increase pulmonary vascular resistance or disrupt normal

pulmonary vasodilation after birth by blocking the action of nitric oxide.

Further research to replicate these findings is needed and to assess

different drugs and dosages, Dr. Chambers said

In an accompanying editorial, L. Mills, M.D., of the National

Institute of Child Health and Human Development in Bethesda, Md., wrote that

the lung disorder is uncommon, so even a sixfold increased risk would not

result in a large number of cases.

Referring to the earlier Israeli report of neonatal withdrawal syndrome in

infants of mothers treated with SSRIs, he said there is pressing need to

compare SSRIs with other forms of treatment. Data are lacking, he wrote, on

the best way to manage depression in pregnant women

Meanwhile, he said, clinicians will need to consider the findings of Dr.

Chambers and colleagues in dealing with the risk-benefit ratio of drug use

Primary source: New England Journal of Medicine, February 9, 2006

Source reference:

Chambers, D., Ph.D, M.P.H, et al. " Selective Serotonin-Reuptake

Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn, "

354; 6: 579-587

[Guest guest]

http://www.medpagetoday.com/OBGYN/Pregnancy/tb/2639

Antidepressants Find Way to Newborn Lungs

By Judith Groch, MedPage Today Staff Writer

Reviewed by Zalman S. Agus, MD; Emeritus Professor at the University of

Pennsylvania School of Medicine.

February 08, 2006

Be aware that in this study the risk of persistent pulmonary pulmonary

hypertension in the newborn (PPHN) is elevated only among women who took

selective serotonin reuptake inhibitors (SSRIs) after the 20th week of

pregnancy.

Explain to patients that other non-SSRI antidepressants had no effect on the

lung disorder.

Although the risk of PPHN is increased five- to sixfold with the use of

SSRIs, only 1% of women taking the drug will have a newborn with PPHN. Thus,

consider with patients both the benefits of SSRIs in the treatment of

depression and the potential risk of PPHN relative to the risks and benefits

of alternative treatments or nontreatment.

Review

SAN DIEGO - Selective serotonin reuptake inhibitors (SSRIs) used late in

pregnancy have been linked to a risk of persistent pulmonary hypertension in

the newborn.

A case-control study found that infants of women who took an SSRI after the

20 weeks of gestation had six times the risk of the lung disorder compared

with babies born of drug-free women, reported D. Chambers, Ph.D.,

M.P.H., of the University of California here and colleagues in the Feb. 9

issue of the New England Journal of Medicine.

The researchers recruited 377 women whose babies had persistent pulmonary

hypertension of the newborn (PPHN) and compared them with 836 matched

controls.

At the end of the 20th week of gestation, 14 infants with the lung disorder

had been exposed to an SSRI compared with only six control infants (adjusted

odds ratio 6.1, 95% CI, 2.2-16.8), the team reported.

Timing and drug type were specific. Neither the use of an SSRI before the

20th week of gestation nor use of non-SSRI antidepressants at any time

during pregnancy was associated with an increased risk of the infant lung

disorder.

The report comes on the heels of two earlier antidepressant studies with

troubling news for pregnant women with major depression. Israeli researchers

found SSRI use linked to neonatal withdrawal syndrome, while Massachusetts

General researchers reported a greater risk of relapse for severely

depressed women who stopped using the drugs during pregnancy.

In the UCSD study, maternal interviews were conducted by nurses who were

blinded to the study hypothesis and potential confounders, including

demographic variables and health history, the researchers said.

Describing the possible biological mechanisms for the effect, the authors

wrote that the lung acts as a reservoir for antidepressants. They suggest

that serotonin may increase pulmonary vascular resistance or disrupt normal

pulmonary vasodilation after birth by blocking the action of nitric oxide.

Further research to replicate these findings is needed and to assess

different drugs and dosages, Dr. Chambers said

In an accompanying editorial, L. Mills, M.D., of the National

Institute of Child Health and Human Development in Bethesda, Md., wrote that

the lung disorder is uncommon, so even a sixfold increased risk would not

result in a large number of cases.

Referring to the earlier Israeli report of neonatal withdrawal syndrome in

infants of mothers treated with SSRIs, he said there is pressing need to

compare SSRIs with other forms of treatment. Data are lacking, he wrote, on

the best way to manage depression in pregnant women

Meanwhile, he said, clinicians will need to consider the findings of Dr.

Chambers and colleagues in dealing with the risk-benefit ratio of drug use

Primary source: New England Journal of Medicine, February 9, 2006

Source reference:

Chambers, D., Ph.D, M.P.H, et al. " Selective Serotonin-Reuptake

Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn, "

354; 6: 579-587

[Guest guest]

http://www.medpagetoday.com/OBGYN/Pregnancy/tb/2639

Antidepressants Find Way to Newborn Lungs

By Judith Groch, MedPage Today Staff Writer

Reviewed by Zalman S. Agus, MD; Emeritus Professor at the University of

Pennsylvania School of Medicine.

February 08, 2006

Be aware that in this study the risk of persistent pulmonary pulmonary

hypertension in the newborn (PPHN) is elevated only among women who took

selective serotonin reuptake inhibitors (SSRIs) after the 20th week of

pregnancy.

Explain to patients that other non-SSRI antidepressants had no effect on the

lung disorder.

Although the risk of PPHN is increased five- to sixfold with the use of

SSRIs, only 1% of women taking the drug will have a newborn with PPHN. Thus,

consider with patients both the benefits of SSRIs in the treatment of

depression and the potential risk of PPHN relative to the risks and benefits

of alternative treatments or nontreatment.

Review

SAN DIEGO - Selective serotonin reuptake inhibitors (SSRIs) used late in

pregnancy have been linked to a risk of persistent pulmonary hypertension in

the newborn.

A case-control study found that infants of women who took an SSRI after the

20 weeks of gestation had six times the risk of the lung disorder compared

with babies born of drug-free women, reported D. Chambers, Ph.D.,

M.P.H., of the University of California here and colleagues in the Feb. 9

issue of the New England Journal of Medicine.

The researchers recruited 377 women whose babies had persistent pulmonary

hypertension of the newborn (PPHN) and compared them with 836 matched

controls.

At the end of the 20th week of gestation, 14 infants with the lung disorder

had been exposed to an SSRI compared with only six control infants (adjusted

odds ratio 6.1, 95% CI, 2.2-16.8), the team reported.

Timing and drug type were specific. Neither the use of an SSRI before the

20th week of gestation nor use of non-SSRI antidepressants at any time

during pregnancy was associated with an increased risk of the infant lung

disorder.

The report comes on the heels of two earlier antidepressant studies with

troubling news for pregnant women with major depression. Israeli researchers

found SSRI use linked to neonatal withdrawal syndrome, while Massachusetts

General researchers reported a greater risk of relapse for severely

depressed women who stopped using the drugs during pregnancy.

In the UCSD study, maternal interviews were conducted by nurses who were

blinded to the study hypothesis and potential confounders, including

demographic variables and health history, the researchers said.

Describing the possible biological mechanisms for the effect, the authors

wrote that the lung acts as a reservoir for antidepressants. They suggest

that serotonin may increase pulmonary vascular resistance or disrupt normal

pulmonary vasodilation after birth by blocking the action of nitric oxide.

Further research to replicate these findings is needed and to assess

different drugs and dosages, Dr. Chambers said

In an accompanying editorial, L. Mills, M.D., of the National

Institute of Child Health and Human Development in Bethesda, Md., wrote that

the lung disorder is uncommon, so even a sixfold increased risk would not

result in a large number of cases.

Referring to the earlier Israeli report of neonatal withdrawal syndrome in

infants of mothers treated with SSRIs, he said there is pressing need to

compare SSRIs with other forms of treatment. Data are lacking, he wrote, on

the best way to manage depression in pregnant women

Meanwhile, he said, clinicians will need to consider the findings of Dr.

Chambers and colleagues in dealing with the risk-benefit ratio of drug use

Primary source: New England Journal of Medicine, February 9, 2006

Source reference:

Chambers, D., Ph.D, M.P.H, et al. " Selective Serotonin-Reuptake

Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn, "

354; 6: 579-587

[Guest guest]

http://www.medpagetoday.com/OBGYN/Pregnancy/tb/2639

Antidepressants Find Way to Newborn Lungs

By Judith Groch, MedPage Today Staff Writer

Reviewed by Zalman S. Agus, MD; Emeritus Professor at the University of

Pennsylvania School of Medicine.

February 08, 2006

Be aware that in this study the risk of persistent pulmonary pulmonary

hypertension in the newborn (PPHN) is elevated only among women who took

selective serotonin reuptake inhibitors (SSRIs) after the 20th week of

pregnancy.

Explain to patients that other non-SSRI antidepressants had no effect on the

lung disorder.

Although the risk of PPHN is increased five- to sixfold with the use of

SSRIs, only 1% of women taking the drug will have a newborn with PPHN. Thus,

consider with patients both the benefits of SSRIs in the treatment of

depression and the potential risk of PPHN relative to the risks and benefits

of alternative treatments or nontreatment.

Review

SAN DIEGO - Selective serotonin reuptake inhibitors (SSRIs) used late in

pregnancy have been linked to a risk of persistent pulmonary hypertension in

the newborn.

A case-control study found that infants of women who took an SSRI after the

20 weeks of gestation had six times the risk of the lung disorder compared

with babies born of drug-free women, reported D. Chambers, Ph.D.,

M.P.H., of the University of California here and colleagues in the Feb. 9

issue of the New England Journal of Medicine.

The researchers recruited 377 women whose babies had persistent pulmonary

hypertension of the newborn (PPHN) and compared them with 836 matched

controls.

At the end of the 20th week of gestation, 14 infants with the lung disorder

had been exposed to an SSRI compared with only six control infants (adjusted

odds ratio 6.1, 95% CI, 2.2-16.8), the team reported.

Timing and drug type were specific. Neither the use of an SSRI before the

20th week of gestation nor use of non-SSRI antidepressants at any time

during pregnancy was associated with an increased risk of the infant lung

disorder.

The report comes on the heels of two earlier antidepressant studies with

troubling news for pregnant women with major depression. Israeli researchers

found SSRI use linked to neonatal withdrawal syndrome, while Massachusetts

General researchers reported a greater risk of relapse for severely

depressed women who stopped using the drugs during pregnancy.

In the UCSD study, maternal interviews were conducted by nurses who were

blinded to the study hypothesis and potential confounders, including

demographic variables and health history, the researchers said.

Describing the possible biological mechanisms for the effect, the authors

wrote that the lung acts as a reservoir for antidepressants. They suggest

that serotonin may increase pulmonary vascular resistance or disrupt normal

pulmonary vasodilation after birth by blocking the action of nitric oxide.

Further research to replicate these findings is needed and to assess

different drugs and dosages, Dr. Chambers said

In an accompanying editorial, L. Mills, M.D., of the National

Institute of Child Health and Human Development in Bethesda, Md., wrote that

the lung disorder is uncommon, so even a sixfold increased risk would not

result in a large number of cases.

Referring to the earlier Israeli report of neonatal withdrawal syndrome in

infants of mothers treated with SSRIs, he said there is pressing need to

compare SSRIs with other forms of treatment. Data are lacking, he wrote, on

the best way to manage depression in pregnant women

Meanwhile, he said, clinicians will need to consider the findings of Dr.

Chambers and colleagues in dealing with the risk-benefit ratio of drug use

Primary source: New England Journal of Medicine, February 9, 2006

Source reference:

Chambers, D., Ph.D, M.P.H, et al. " Selective Serotonin-Reuptake

Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn, "

354; 6: 579-587

[Guest guest]

I don't quite understand the connection btwn SSRIs and the lungs but I

know that I have felt a 'heaviness' on my lungs when I took them. Even

today, the Trazadone I take, I can only take intermittantly because It

leaves me with a feeling of heaviness or 'water' on the lungs if I take

it too long.

[Guest guest]

I don't quite understand the connection btwn SSRIs and the lungs but I

know that I have felt a 'heaviness' on my lungs when I took them. Even

today, the Trazadone I take, I can only take intermittantly because It

leaves me with a feeling of heaviness or 'water' on the lungs if I take

it too long.

[Guest guest]

I don't quite understand the connection btwn SSRIs and the lungs but I

know that I have felt a 'heaviness' on my lungs when I took them. Even

today, the Trazadone I take, I can only take intermittantly because It

leaves me with a feeling of heaviness or 'water' on the lungs if I take

it too long.

[Guest guest]

I don't quite understand the connection btwn SSRIs and the lungs but I

know that I have felt a 'heaviness' on my lungs when I took them. Even

today, the Trazadone I take, I can only take intermittantly because It

leaves me with a feeling of heaviness or 'water' on the lungs if I take

it too long.

[Guest guest]

I noticed , when taking triazadone, I would barely breathe

during sleep.

Others I knew developed sleep apnia , but the dox never

told them what was causing it .

It caused you to quit breathing in your sleep.

Same for the closipan studies, and incontinence.

Insted of W/D of the ssri, they fit you with pampers.

With me the last straw , was 4 years of blindness with T/D

in the eyes.

They wanted to inject botox, instead of just

W/D , then lied about the cause, saying it

was trillafon.

They W/D my trillafon, after 25 years taking

it daily . The trillafon with zpam and maos

produced suicidal ideas. Those were acceptable.

At the W/D of trillafon , cold turkey, they

administered another ssri, and when taking that

I had terrible homicidal ideas, with nightmares

attached so horrible, I had to go back on the

trillafon. I threw them away, as an evil thing .

They want us locked up , so their studies can

be more controled/clinical .

During the studies they constantly ask,

are you feeling suicidal, or homicidal.

They dont care one way or another how we feel about it.

Its their studies, they are so compulsive about.

THEY MUST, THEY MUST, its that important for them

to do this to us.

Look at how important nazi psych studies were during ww2.

They would risk their lives, for their notebooks.

The bio chem experiments must have been _____.

Looking at the Japaneese , they worked with the dead

in very _____ ways.

I continued to believe , the german psychs used eels

for their first psych med experiments, then compounded

chemicals from their blood .

Its that taste , the certain smell that reminds me

of that.

Then the T/D in the neck , the gyration of the limbs

very similar to an eel.

I had heard of psych given spinal shots ,

using animal compounds.

I used dupont amantadine , during the whole time

taking ssris. They say that will stop the flu

so possibly, it keeps many from developing pnumonia.

By denial of rem sleep, the nightmares are many per night.

>

>

>

> I don't quite understand the connection btwn SSRIs and the lungs

but I

> know that I have felt a 'heaviness' on my lungs when I took them.

Even

> today, the Trazadone I take, I can only take intermittantly

because It

> leaves me with a feeling of heaviness or 'water' on the lungs if I

take

> it too long.

>

[Guest guest]

I noticed , when taking triazadone, I would barely breathe

during sleep.

Others I knew developed sleep apnia , but the dox never

told them what was causing it .

It caused you to quit breathing in your sleep.

Same for the closipan studies, and incontinence.

Insted of W/D of the ssri, they fit you with pampers.

With me the last straw , was 4 years of blindness with T/D

in the eyes.

They wanted to inject botox, instead of just

W/D , then lied about the cause, saying it

was trillafon.

They W/D my trillafon, after 25 years taking

it daily . The trillafon with zpam and maos

produced suicidal ideas. Those were acceptable.

At the W/D of trillafon , cold turkey, they

administered another ssri, and when taking that

I had terrible homicidal ideas, with nightmares

attached so horrible, I had to go back on the

trillafon. I threw them away, as an evil thing .

They want us locked up , so their studies can

be more controled/clinical .

During the studies they constantly ask,

are you feeling suicidal, or homicidal.

They dont care one way or another how we feel about it.

Its their studies, they are so compulsive about.

THEY MUST, THEY MUST, its that important for them

to do this to us.

Look at how important nazi psych studies were during ww2.

They would risk their lives, for their notebooks.

The bio chem experiments must have been _____.

Looking at the Japaneese , they worked with the dead

in very _____ ways.

I continued to believe , the german psychs used eels

for their first psych med experiments, then compounded

chemicals from their blood .

Its that taste , the certain smell that reminds me

of that.

Then the T/D in the neck , the gyration of the limbs

very similar to an eel.

I had heard of psych given spinal shots ,

using animal compounds.

I used dupont amantadine , during the whole time

taking ssris. They say that will stop the flu

so possibly, it keeps many from developing pnumonia.

By denial of rem sleep, the nightmares are many per night.

>

>

>

> I don't quite understand the connection btwn SSRIs and the lungs

but I

> know that I have felt a 'heaviness' on my lungs when I took them.

Even

> today, the Trazadone I take, I can only take intermittantly

because It

> leaves me with a feeling of heaviness or 'water' on the lungs if I

take

> it too long.

>

[Guest guest]

I noticed , when taking triazadone, I would barely breathe

during sleep.

Others I knew developed sleep apnia , but the dox never

told them what was causing it .

It caused you to quit breathing in your sleep.

Same for the closipan studies, and incontinence.

Insted of W/D of the ssri, they fit you with pampers.

With me the last straw , was 4 years of blindness with T/D

in the eyes.

They wanted to inject botox, instead of just

W/D , then lied about the cause, saying it

was trillafon.

They W/D my trillafon, after 25 years taking

it daily . The trillafon with zpam and maos

produced suicidal ideas. Those were acceptable.

At the W/D of trillafon , cold turkey, they

administered another ssri, and when taking that

I had terrible homicidal ideas, with nightmares

attached so horrible, I had to go back on the

trillafon. I threw them away, as an evil thing .

They want us locked up , so their studies can

be more controled/clinical .

During the studies they constantly ask,

are you feeling suicidal, or homicidal.

They dont care one way or another how we feel about it.

Its their studies, they are so compulsive about.

THEY MUST, THEY MUST, its that important for them

to do this to us.

Look at how important nazi psych studies were during ww2.

They would risk their lives, for their notebooks.

The bio chem experiments must have been _____.

Looking at the Japaneese , they worked with the dead

in very _____ ways.

I continued to believe , the german psychs used eels

for their first psych med experiments, then compounded

chemicals from their blood .

Its that taste , the certain smell that reminds me

of that.

Then the T/D in the neck , the gyration of the limbs

very similar to an eel.

I had heard of psych given spinal shots ,

using animal compounds.

I used dupont amantadine , during the whole time

taking ssris. They say that will stop the flu

so possibly, it keeps many from developing pnumonia.

By denial of rem sleep, the nightmares are many per night.

>

>

>

> I don't quite understand the connection btwn SSRIs and the lungs

but I

> know that I have felt a 'heaviness' on my lungs when I took them.

Even

> today, the Trazadone I take, I can only take intermittantly

because It

> leaves me with a feeling of heaviness or 'water' on the lungs if I

take

> it too long.

>

[Guest guest]

I noticed , when taking triazadone, I would barely breathe

during sleep.

Others I knew developed sleep apnia , but the dox never

told them what was causing it .

It caused you to quit breathing in your sleep.

Same for the closipan studies, and incontinence.

Insted of W/D of the ssri, they fit you with pampers.

With me the last straw , was 4 years of blindness with T/D

in the eyes.

They wanted to inject botox, instead of just

W/D , then lied about the cause, saying it

was trillafon.

They W/D my trillafon, after 25 years taking

it daily . The trillafon with zpam and maos

produced suicidal ideas. Those were acceptable.

At the W/D of trillafon , cold turkey, they

administered another ssri, and when taking that

I had terrible homicidal ideas, with nightmares

attached so horrible, I had to go back on the

trillafon. I threw them away, as an evil thing .

They want us locked up , so their studies can

be more controled/clinical .

During the studies they constantly ask,

are you feeling suicidal, or homicidal.

They dont care one way or another how we feel about it.

Its their studies, they are so compulsive about.

THEY MUST, THEY MUST, its that important for them

to do this to us.

Look at how important nazi psych studies were during ww2.

They would risk their lives, for their notebooks.

The bio chem experiments must have been _____.

Looking at the Japaneese , they worked with the dead

in very _____ ways.

I continued to believe , the german psychs used eels

for their first psych med experiments, then compounded

chemicals from their blood .

Its that taste , the certain smell that reminds me

of that.

Then the T/D in the neck , the gyration of the limbs

very similar to an eel.

I had heard of psych given spinal shots ,

using animal compounds.

I used dupont amantadine , during the whole time

taking ssris. They say that will stop the flu

so possibly, it keeps many from developing pnumonia.

By denial of rem sleep, the nightmares are many per night.

>

>

>

> I don't quite understand the connection btwn SSRIs and the lungs

but I

> know that I have felt a 'heaviness' on my lungs when I took them.

Even

> today, the Trazadone I take, I can only take intermittantly

because It

> leaves me with a feeling of heaviness or 'water' on the lungs if I

take

> it too long.

>