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Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3 infections

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Journal of Viral Hepatitis

Volume 11 Issue 5 Page 455 - September 2004

doi:10.1111/j.1365-2893.2004.00528.x

Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3

infections

C. Hézode1,2, F. Roudot-Thoraval2,3, E.-S. Zafrani4, D. Dhumeaux1,2 and

J.-M. Pawlotsky2

Summary. This study reports evidence that hepatocellular steatosis, a

frequent histological feature of chronic hepatitis C, is principally

metabolic in hepatitis C virus (HCV) genotype 1-infected patients, whereas

it is principally virus-induced in HCV genotype 3-infected patients.

Multivariate analysis of data on 176 patients with chronic hepatitis C

revealed that the severity of steatosis was independently related to HCV RNA

load alone in patients infected by HCV genotype 3, whereas it was

independently related to the body mass index, daily alcohol intake and

histological activity grade (but not viral load) in patients infected by HCV

genotype 1. These findings suggest that steatosis is a cytopathic lesion

induced by HCV genotype 3, whereas HCV genotype 1 is not steatogenic per se

or at the usual in vivo expression levels.

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Posted
Posted

Journal of Viral Hepatitis

Volume 11 Issue 5 Page 455 - September 2004

doi:10.1111/j.1365-2893.2004.00528.x

Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3

infections

C. Hézode1,2, F. Roudot-Thoraval2,3, E.-S. Zafrani4, D. Dhumeaux1,2 and

J.-M. Pawlotsky2

Summary. This study reports evidence that hepatocellular steatosis, a

frequent histological feature of chronic hepatitis C, is principally

metabolic in hepatitis C virus (HCV) genotype 1-infected patients, whereas

it is principally virus-induced in HCV genotype 3-infected patients.

Multivariate analysis of data on 176 patients with chronic hepatitis C

revealed that the severity of steatosis was independently related to HCV RNA

load alone in patients infected by HCV genotype 3, whereas it was

independently related to the body mass index, daily alcohol intake and

histological activity grade (but not viral load) in patients infected by HCV

genotype 1. These findings suggest that steatosis is a cytopathic lesion

induced by HCV genotype 3, whereas HCV genotype 1 is not steatogenic per se

or at the usual in vivo expression levels.

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Guest guest

Guest guest

Posted
Posted

Journal of Viral Hepatitis

Volume 11 Issue 5 Page 455 - September 2004

doi:10.1111/j.1365-2893.2004.00528.x

Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3

infections

C. Hézode1,2, F. Roudot-Thoraval2,3, E.-S. Zafrani4, D. Dhumeaux1,2 and

J.-M. Pawlotsky2

Summary. This study reports evidence that hepatocellular steatosis, a

frequent histological feature of chronic hepatitis C, is principally

metabolic in hepatitis C virus (HCV) genotype 1-infected patients, whereas

it is principally virus-induced in HCV genotype 3-infected patients.

Multivariate analysis of data on 176 patients with chronic hepatitis C

revealed that the severity of steatosis was independently related to HCV RNA

load alone in patients infected by HCV genotype 3, whereas it was

independently related to the body mass index, daily alcohol intake and

histological activity grade (but not viral load) in patients infected by HCV

genotype 1. These findings suggest that steatosis is a cytopathic lesion

induced by HCV genotype 3, whereas HCV genotype 1 is not steatogenic per se

or at the usual in vivo expression levels.

Link to comment
Share on other sites
Guest guest

Guest guest

Posted
Posted

Journal of Viral Hepatitis

Volume 11 Issue 5 Page 455 - September 2004

doi:10.1111/j.1365-2893.2004.00528.x

Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3

infections

C. Hézode1,2, F. Roudot-Thoraval2,3, E.-S. Zafrani4, D. Dhumeaux1,2 and

J.-M. Pawlotsky2

Summary. This study reports evidence that hepatocellular steatosis, a

frequent histological feature of chronic hepatitis C, is principally

metabolic in hepatitis C virus (HCV) genotype 1-infected patients, whereas

it is principally virus-induced in HCV genotype 3-infected patients.

Multivariate analysis of data on 176 patients with chronic hepatitis C

revealed that the severity of steatosis was independently related to HCV RNA

load alone in patients infected by HCV genotype 3, whereas it was

independently related to the body mass index, daily alcohol intake and

histological activity grade (but not viral load) in patients infected by HCV

genotype 1. These findings suggest that steatosis is a cytopathic lesion

induced by HCV genotype 3, whereas HCV genotype 1 is not steatogenic per se

or at the usual in vivo expression levels.

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