Large-Scale Candidate Gene Analysis of Spontaneous Clearance of Hepatitis C Virus.

[Guest guest]

J Infect Dis. 2010 Mar 5. [Epub ahead of print]Large-Scale Candidate Gene

Analysis of Spontaneous Clearance of Hepatitis C Virus.Mosbruger TL, Duggal P,

Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, s MG, Rosen HR,

DL, Thio CL.s Hopkins University, Baltimore, 2Infections and

Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics,

National Cancer Institute, and 3Division of Blood Diseases and Resources,

National Heart, Lung, and Blood Institute, Bethesda, land; 4Blood Systems

Research Institute and 5University of California, San Francisco; and 6University

of Colorado, Denver.Human genetic variation is a determinant of recovery from

acute hepatitis C virus (HCV) infection; however, to date, single-nucleotide

polymorphisms (SNPs) in only a limited number of genes have been studied with

respect to HCV clearance. We determined whether SNPs in 112 selected immune

response genes are important for HCV clearance, by genotyping 1536 SNPs in a

cohort of 343 persons with natural HCV clearance and 547 persons with HCV

persistence. PLINK (version 1.05) and Haploview (version 4.1) software packages

were used to perform association, permutation, and haplotype analyses stratified

by African American and European American race. Of the 1536 SNPs tested, 1426

(92.8%) were successfully genotyped. In African Americans, we identified 18 SNPs

located in 11 gene regions that were associated with HCV infection outcome

(empirical P value, < .01). In European Americans, there were 20 SNPs located in

8 gene regions associated with HCV infection outcome. Four of the gene regions

studied (TNFSF18, TANK, HAVCR1, and IL18BP) contained SNPs for which the

empirical P value was <.01 in both of the race groups. In this large-scale

analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene

regions that are likely candidates for a role in HCV clearance or persistence in

both African Americans and European Americans.PMID: 20331378 [PubMed - as

supplied by publisher]

[Guest guest]

J Infect Dis. 2010 Mar 5. [Epub ahead of print]Large-Scale Candidate Gene

Analysis of Spontaneous Clearance of Hepatitis C Virus.Mosbruger TL, Duggal P,

Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, s MG, Rosen HR,

DL, Thio CL.s Hopkins University, Baltimore, 2Infections and

Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics,

National Cancer Institute, and 3Division of Blood Diseases and Resources,

National Heart, Lung, and Blood Institute, Bethesda, land; 4Blood Systems

Research Institute and 5University of California, San Francisco; and 6University

of Colorado, Denver.Human genetic variation is a determinant of recovery from

acute hepatitis C virus (HCV) infection; however, to date, single-nucleotide

polymorphisms (SNPs) in only a limited number of genes have been studied with

respect to HCV clearance. We determined whether SNPs in 112 selected immune

response genes are important for HCV clearance, by genotyping 1536 SNPs in a

cohort of 343 persons with natural HCV clearance and 547 persons with HCV

persistence. PLINK (version 1.05) and Haploview (version 4.1) software packages

were used to perform association, permutation, and haplotype analyses stratified

by African American and European American race. Of the 1536 SNPs tested, 1426

(92.8%) were successfully genotyped. In African Americans, we identified 18 SNPs

located in 11 gene regions that were associated with HCV infection outcome

(empirical P value, < .01). In European Americans, there were 20 SNPs located in

8 gene regions associated with HCV infection outcome. Four of the gene regions

studied (TNFSF18, TANK, HAVCR1, and IL18BP) contained SNPs for which the

empirical P value was <.01 in both of the race groups. In this large-scale

analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene

regions that are likely candidates for a role in HCV clearance or persistence in

both African Americans and European Americans.PMID: 20331378 [PubMed - as

supplied by publisher]

[Guest guest]

J Infect Dis. 2010 Mar 5. [Epub ahead of print]Large-Scale Candidate Gene

Analysis of Spontaneous Clearance of Hepatitis C Virus.Mosbruger TL, Duggal P,

Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, s MG, Rosen HR,

DL, Thio CL.s Hopkins University, Baltimore, 2Infections and

Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics,

National Cancer Institute, and 3Division of Blood Diseases and Resources,

National Heart, Lung, and Blood Institute, Bethesda, land; 4Blood Systems

Research Institute and 5University of California, San Francisco; and 6University

of Colorado, Denver.Human genetic variation is a determinant of recovery from

acute hepatitis C virus (HCV) infection; however, to date, single-nucleotide

polymorphisms (SNPs) in only a limited number of genes have been studied with

respect to HCV clearance. We determined whether SNPs in 112 selected immune

response genes are important for HCV clearance, by genotyping 1536 SNPs in a

cohort of 343 persons with natural HCV clearance and 547 persons with HCV

persistence. PLINK (version 1.05) and Haploview (version 4.1) software packages

were used to perform association, permutation, and haplotype analyses stratified

by African American and European American race. Of the 1536 SNPs tested, 1426

(92.8%) were successfully genotyped. In African Americans, we identified 18 SNPs

located in 11 gene regions that were associated with HCV infection outcome

(empirical P value, < .01). In European Americans, there were 20 SNPs located in

8 gene regions associated with HCV infection outcome. Four of the gene regions

studied (TNFSF18, TANK, HAVCR1, and IL18BP) contained SNPs for which the

empirical P value was <.01 in both of the race groups. In this large-scale

analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene

regions that are likely candidates for a role in HCV clearance or persistence in

both African Americans and European Americans.PMID: 20331378 [PubMed - as

supplied by publisher]

[Guest guest]

J Infect Dis. 2010 Mar 5. [Epub ahead of print]Large-Scale Candidate Gene

Analysis of Spontaneous Clearance of Hepatitis C Virus.Mosbruger TL, Duggal P,

Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, s MG, Rosen HR,

DL, Thio CL.s Hopkins University, Baltimore, 2Infections and

Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics,

National Cancer Institute, and 3Division of Blood Diseases and Resources,

National Heart, Lung, and Blood Institute, Bethesda, land; 4Blood Systems

Research Institute and 5University of California, San Francisco; and 6University

of Colorado, Denver.Human genetic variation is a determinant of recovery from

acute hepatitis C virus (HCV) infection; however, to date, single-nucleotide

polymorphisms (SNPs) in only a limited number of genes have been studied with

respect to HCV clearance. We determined whether SNPs in 112 selected immune

response genes are important for HCV clearance, by genotyping 1536 SNPs in a

cohort of 343 persons with natural HCV clearance and 547 persons with HCV

persistence. PLINK (version 1.05) and Haploview (version 4.1) software packages

were used to perform association, permutation, and haplotype analyses stratified

by African American and European American race. Of the 1536 SNPs tested, 1426

(92.8%) were successfully genotyped. In African Americans, we identified 18 SNPs

located in 11 gene regions that were associated with HCV infection outcome

(empirical P value, < .01). In European Americans, there were 20 SNPs located in

8 gene regions associated with HCV infection outcome. Four of the gene regions

studied (TNFSF18, TANK, HAVCR1, and IL18BP) contained SNPs for which the

empirical P value was <.01 in both of the race groups. In this large-scale

analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene

regions that are likely candidates for a role in HCV clearance or persistence in

both African Americans and European Americans.PMID: 20331378 [PubMed - as

supplied by publisher]