THE SIGNFICANCE OF HEPATITIS B VIRUS GENOTYPES AND MUTATIONS IN THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN ASIA

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http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2010.06514.x/abstract?sys\

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THE SIGNFICANCE OF HEPATITIS B VIRUS GENOTYPES AND MUTATIONS IN THE DEVELOPMENT

OF HEPATOCELLULAR CARCINOMA IN ASIA

Henry Lik-Yuen Chan MDDOI: 10.1111/j.1440-1746.2010.06514.x

Journal compilation © 2010 Journal of Gastroenterology and Hepatology Foundation

and Blackwell Publishing Asia Pty Ltd

Issue

Journal of Gastroenterology and Hepatology

Accepted Article (Accepted, unedited articles published online for future

issues)

ABSTRACT

Advances in molecular biology technology in the last 2 decades have allowed

detailed study of the viral mutations and genomic heterogeneity of hepatitis B

virus (HBV). The first mutant discovered was precore stop codon mutation. It was

reported in HBeAg-negative patients and initially thought to associate with

fulminant hepatitis. Subsequent studies have suggested that it is merely one of

the mechanisms of losing HBeAg by the virus. Another mutation that can

down-regulate the production of HBeAg is the basal core promoter mutation, which

is located in the X gene upstream of the precore region. Based on the

configuration of codon 15 and the stability of the epsilon of the precore

region, these 2 mutants will be differentially selected during the course of

HBeAg seroconversion. The commonest HBV genotypes in Southeast Asia are genotype

B and C HBV. The higher HCC risk of genotype C HBV has been confirmed by

longitudinal studies in Hong Kong and Taiwan. One possible carcinogenic

mechanism is its association with basal core promoter mutation, which has also

been found a risk factor of hepatocellular carcinoma (HCC). Within genotype C

HBV, subgenotype Cs is predominant in Southeast Asia and subgenotype Ce is

predominant in East Asia. Subgenotype Ce HBV has been found to have the highest

risk of HCC as compared to subgenotype Cs or genotype B HBV. The understanding

of the carcinogenic mechanisms of these HBV strains may shed light into future

therapeutics in the prevention and treatment of HBV-related HCC.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2010.06514.x/abstract?sys\

temMessage=Due+to+scheduled+maintenance+access+to+the+Wiley+Online+Library+may+b\

e+disrupted+as+follows%3A+Saturday%2C+2+October+-+New+York+0500+EDT+to+0700+EDT%\

3B+London+1000+BST+to+1200+BST%3B+Singapore+1700+SGT+to+1900+SGT.

THE SIGNFICANCE OF HEPATITIS B VIRUS GENOTYPES AND MUTATIONS IN THE DEVELOPMENT

OF HEPATOCELLULAR CARCINOMA IN ASIA

Henry Lik-Yuen Chan MDDOI: 10.1111/j.1440-1746.2010.06514.x

Journal compilation © 2010 Journal of Gastroenterology and Hepatology Foundation

and Blackwell Publishing Asia Pty Ltd

Issue

Journal of Gastroenterology and Hepatology

Accepted Article (Accepted, unedited articles published online for future

issues)

ABSTRACT

Advances in molecular biology technology in the last 2 decades have allowed

detailed study of the viral mutations and genomic heterogeneity of hepatitis B

virus (HBV). The first mutant discovered was precore stop codon mutation. It was

reported in HBeAg-negative patients and initially thought to associate with

fulminant hepatitis. Subsequent studies have suggested that it is merely one of

the mechanisms of losing HBeAg by the virus. Another mutation that can

down-regulate the production of HBeAg is the basal core promoter mutation, which

is located in the X gene upstream of the precore region. Based on the

configuration of codon 15 and the stability of the epsilon of the precore

region, these 2 mutants will be differentially selected during the course of

HBeAg seroconversion. The commonest HBV genotypes in Southeast Asia are genotype

B and C HBV. The higher HCC risk of genotype C HBV has been confirmed by

longitudinal studies in Hong Kong and Taiwan. One possible carcinogenic

mechanism is its association with basal core promoter mutation, which has also

been found a risk factor of hepatocellular carcinoma (HCC). Within genotype C

HBV, subgenotype Cs is predominant in Southeast Asia and subgenotype Ce is

predominant in East Asia. Subgenotype Ce HBV has been found to have the highest

risk of HCC as compared to subgenotype Cs or genotype B HBV. The understanding

of the carcinogenic mechanisms of these HBV strains may shed light into future

therapeutics in the prevention and treatment of HBV-related HCC.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2010.06514.x/abstract?sys\

temMessage=Due+to+scheduled+maintenance+access+to+the+Wiley+Online+Library+may+b\

e+disrupted+as+follows%3A+Saturday%2C+2+October+-+New+York+0500+EDT+to+0700+EDT%\

3B+London+1000+BST+to+1200+BST%3B+Singapore+1700+SGT+to+1900+SGT.

THE SIGNFICANCE OF HEPATITIS B VIRUS GENOTYPES AND MUTATIONS IN THE DEVELOPMENT

OF HEPATOCELLULAR CARCINOMA IN ASIA

Henry Lik-Yuen Chan MDDOI: 10.1111/j.1440-1746.2010.06514.x

Journal compilation © 2010 Journal of Gastroenterology and Hepatology Foundation

and Blackwell Publishing Asia Pty Ltd

Issue

Journal of Gastroenterology and Hepatology

Accepted Article (Accepted, unedited articles published online for future

issues)

ABSTRACT

Advances in molecular biology technology in the last 2 decades have allowed

detailed study of the viral mutations and genomic heterogeneity of hepatitis B

virus (HBV). The first mutant discovered was precore stop codon mutation. It was

reported in HBeAg-negative patients and initially thought to associate with

fulminant hepatitis. Subsequent studies have suggested that it is merely one of

the mechanisms of losing HBeAg by the virus. Another mutation that can

down-regulate the production of HBeAg is the basal core promoter mutation, which

is located in the X gene upstream of the precore region. Based on the

configuration of codon 15 and the stability of the epsilon of the precore

region, these 2 mutants will be differentially selected during the course of

HBeAg seroconversion. The commonest HBV genotypes in Southeast Asia are genotype

B and C HBV. The higher HCC risk of genotype C HBV has been confirmed by

longitudinal studies in Hong Kong and Taiwan. One possible carcinogenic

mechanism is its association with basal core promoter mutation, which has also

been found a risk factor of hepatocellular carcinoma (HCC). Within genotype C

HBV, subgenotype Cs is predominant in Southeast Asia and subgenotype Ce is

predominant in East Asia. Subgenotype Ce HBV has been found to have the highest

risk of HCC as compared to subgenotype Cs or genotype B HBV. The understanding

of the carcinogenic mechanisms of these HBV strains may shed light into future

therapeutics in the prevention and treatment of HBV-related HCC.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2010.06514.x/abstract?sys\

temMessage=Due+to+scheduled+maintenance+access+to+the+Wiley+Online+Library+may+b\

e+disrupted+as+follows%3A+Saturday%2C+2+October+-+New+York+0500+EDT+to+0700+EDT%\

3B+London+1000+BST+to+1200+BST%3B+Singapore+1700+SGT+to+1900+SGT.

THE SIGNFICANCE OF HEPATITIS B VIRUS GENOTYPES AND MUTATIONS IN THE DEVELOPMENT

OF HEPATOCELLULAR CARCINOMA IN ASIA

Henry Lik-Yuen Chan MDDOI: 10.1111/j.1440-1746.2010.06514.x

Journal compilation © 2010 Journal of Gastroenterology and Hepatology Foundation

and Blackwell Publishing Asia Pty Ltd

Issue

Journal of Gastroenterology and Hepatology

Accepted Article (Accepted, unedited articles published online for future

issues)

ABSTRACT

Advances in molecular biology technology in the last 2 decades have allowed

detailed study of the viral mutations and genomic heterogeneity of hepatitis B

virus (HBV). The first mutant discovered was precore stop codon mutation. It was

reported in HBeAg-negative patients and initially thought to associate with

fulminant hepatitis. Subsequent studies have suggested that it is merely one of

the mechanisms of losing HBeAg by the virus. Another mutation that can

down-regulate the production of HBeAg is the basal core promoter mutation, which

is located in the X gene upstream of the precore region. Based on the

configuration of codon 15 and the stability of the epsilon of the precore

region, these 2 mutants will be differentially selected during the course of

HBeAg seroconversion. The commonest HBV genotypes in Southeast Asia are genotype

B and C HBV. The higher HCC risk of genotype C HBV has been confirmed by

longitudinal studies in Hong Kong and Taiwan. One possible carcinogenic

mechanism is its association with basal core promoter mutation, which has also

been found a risk factor of hepatocellular carcinoma (HCC). Within genotype C

HBV, subgenotype Cs is predominant in Southeast Asia and subgenotype Ce is

predominant in East Asia. Subgenotype Ce HBV has been found to have the highest

risk of HCC as compared to subgenotype Cs or genotype B HBV. The understanding

of the carcinogenic mechanisms of these HBV strains may shed light into future

therapeutics in the prevention and treatment of HBV-related HCC.