Antiretrovirus Enzyme Works Against HBV Too

[Guest guest]

Antiretrovirus Enzyme Works Against HBV Too

NEW YORK (Reuters Health) Mar 18 - APOBEC3G, a cellular enzyme that provides

retroviral protection, also seems to inhibit the replication of hepatitis B

virus (HBV), according to a report published in the March 19th issue of

Science.

" Our work broadens the spectrum of known viruses inhibited by APOBEC3G, " Dr.

Didier Trono and colleagues, from the University of Geneva in Switzerland,

note.

Using a variety of laboratory techniques, the researchers found that HBV DNA

levels were reduced in cells transfected with APOBEC3G. The enzyme seemed to

achieve this effect not by targeting nascent viral DNA, as occurs with

retroviruses, but by inhibiting pregenomic RNA packaging.

" Whether the sole role of [APOBEC3G] is to provide antiviral protection or

whether it first evolved to fulfill other functions within the cell is an

interesting question, " the investigators note.

Science 2004;303:1829.

[Guest guest]

Antiretrovirus Enzyme Works Against HBV Too

NEW YORK (Reuters Health) Mar 18 - APOBEC3G, a cellular enzyme that provides

retroviral protection, also seems to inhibit the replication of hepatitis B

virus (HBV), according to a report published in the March 19th issue of

Science.

" Our work broadens the spectrum of known viruses inhibited by APOBEC3G, " Dr.

Didier Trono and colleagues, from the University of Geneva in Switzerland,

note.

Using a variety of laboratory techniques, the researchers found that HBV DNA

levels were reduced in cells transfected with APOBEC3G. The enzyme seemed to

achieve this effect not by targeting nascent viral DNA, as occurs with

retroviruses, but by inhibiting pregenomic RNA packaging.

" Whether the sole role of [APOBEC3G] is to provide antiviral protection or

whether it first evolved to fulfill other functions within the cell is an

interesting question, " the investigators note.

Science 2004;303:1829.

[Guest guest]

Antiretrovirus Enzyme Works Against HBV Too

NEW YORK (Reuters Health) Mar 18 - APOBEC3G, a cellular enzyme that provides

retroviral protection, also seems to inhibit the replication of hepatitis B

virus (HBV), according to a report published in the March 19th issue of

Science.

" Our work broadens the spectrum of known viruses inhibited by APOBEC3G, " Dr.

Didier Trono and colleagues, from the University of Geneva in Switzerland,

note.

Using a variety of laboratory techniques, the researchers found that HBV DNA

levels were reduced in cells transfected with APOBEC3G. The enzyme seemed to

achieve this effect not by targeting nascent viral DNA, as occurs with

retroviruses, but by inhibiting pregenomic RNA packaging.

" Whether the sole role of [APOBEC3G] is to provide antiviral protection or

whether it first evolved to fulfill other functions within the cell is an

interesting question, " the investigators note.

Science 2004;303:1829.

[Guest guest]

Antiretrovirus Enzyme Works Against HBV Too

NEW YORK (Reuters Health) Mar 18 - APOBEC3G, a cellular enzyme that provides

retroviral protection, also seems to inhibit the replication of hepatitis B

virus (HBV), according to a report published in the March 19th issue of

Science.

" Our work broadens the spectrum of known viruses inhibited by APOBEC3G, " Dr.

Didier Trono and colleagues, from the University of Geneva in Switzerland,

note.

Using a variety of laboratory techniques, the researchers found that HBV DNA

levels were reduced in cells transfected with APOBEC3G. The enzyme seemed to

achieve this effect not by targeting nascent viral DNA, as occurs with

retroviruses, but by inhibiting pregenomic RNA packaging.

" Whether the sole role of [APOBEC3G] is to provide antiviral protection or

whether it first evolved to fulfill other functions within the cell is an

interesting question, " the investigators note.

Science 2004;303:1829.