Thiamine treatment of chronic hepatitis B infection

[Guest guest]

1: Am J Gastroenterol 2001 Mar;96(3):864-8

Thiamine treatment of chronic hepatitis B infection.

Wallace AE, Weeks WB

Department of Psychiatry and Community and Family Medicine, Dartmouth

Medical School, Hanover, New Hampshire, USA.

[Medline record in process]

OBJECTIVE: Chronic hepatitis B is an international health concern that

causes cirrhosis, hepatocellular carcinoma, liver failure, and death.

Current treatment options are expensive and associated with side effects;

however, indirect evidence suggests a relationship between relative thiamine

deficiency and chronic hepatitis B infection. METHODS: The authors present

three case studies wherein multiple crossovers of daily thiamine

administration were used to evaluate a hypothesized association between

thiamine treatment and aminotransferase levels. RESULTS: In each case study,

thiamine administration was associated with reduction in aminotransferase

levels and the fall of HBV DNA to undetectable levels. Analyses by t test

demonstrated a statistically significant reduction in aminotransferase

levels in all three cases. CONCLUSIONS: The relationship between thiamine

administration and chronic hepatitis B infection warrants further study. If

proven effective in reducing liver damage or inducing remission of the

hepatitis B virus in larger trials, thiamine will offer obvious advantages

over the current treatments for chronic viral hepatitis B infection.

PMID: 11280566

[Guest guest]

1: Am J Gastroenterol 2001 Mar;96(3):864-8

Thiamine treatment of chronic hepatitis B infection.

Wallace AE, Weeks WB

Department of Psychiatry and Community and Family Medicine, Dartmouth

Medical School, Hanover, New Hampshire, USA.

[Medline record in process]

OBJECTIVE: Chronic hepatitis B is an international health concern that

causes cirrhosis, hepatocellular carcinoma, liver failure, and death.

Current treatment options are expensive and associated with side effects;

however, indirect evidence suggests a relationship between relative thiamine

deficiency and chronic hepatitis B infection. METHODS: The authors present

three case studies wherein multiple crossovers of daily thiamine

administration were used to evaluate a hypothesized association between

thiamine treatment and aminotransferase levels. RESULTS: In each case study,

thiamine administration was associated with reduction in aminotransferase

levels and the fall of HBV DNA to undetectable levels. Analyses by t test

demonstrated a statistically significant reduction in aminotransferase

levels in all three cases. CONCLUSIONS: The relationship between thiamine

administration and chronic hepatitis B infection warrants further study. If

proven effective in reducing liver damage or inducing remission of the

hepatitis B virus in larger trials, thiamine will offer obvious advantages

over the current treatments for chronic viral hepatitis B infection.

PMID: 11280566

[Guest guest]

1: Am J Gastroenterol 2001 Mar;96(3):864-8

Thiamine treatment of chronic hepatitis B infection.

Wallace AE, Weeks WB

Department of Psychiatry and Community and Family Medicine, Dartmouth

Medical School, Hanover, New Hampshire, USA.

[Medline record in process]

OBJECTIVE: Chronic hepatitis B is an international health concern that

causes cirrhosis, hepatocellular carcinoma, liver failure, and death.

Current treatment options are expensive and associated with side effects;

however, indirect evidence suggests a relationship between relative thiamine

deficiency and chronic hepatitis B infection. METHODS: The authors present

three case studies wherein multiple crossovers of daily thiamine

administration were used to evaluate a hypothesized association between

thiamine treatment and aminotransferase levels. RESULTS: In each case study,

thiamine administration was associated with reduction in aminotransferase

levels and the fall of HBV DNA to undetectable levels. Analyses by t test

demonstrated a statistically significant reduction in aminotransferase

levels in all three cases. CONCLUSIONS: The relationship between thiamine

administration and chronic hepatitis B infection warrants further study. If

proven effective in reducing liver damage or inducing remission of the

hepatitis B virus in larger trials, thiamine will offer obvious advantages

over the current treatments for chronic viral hepatitis B infection.

PMID: 11280566

[Guest guest]

1: Am J Gastroenterol 2001 Mar;96(3):864-8

Thiamine treatment of chronic hepatitis B infection.

Wallace AE, Weeks WB

Department of Psychiatry and Community and Family Medicine, Dartmouth

Medical School, Hanover, New Hampshire, USA.

[Medline record in process]

OBJECTIVE: Chronic hepatitis B is an international health concern that

causes cirrhosis, hepatocellular carcinoma, liver failure, and death.

Current treatment options are expensive and associated with side effects;

however, indirect evidence suggests a relationship between relative thiamine

deficiency and chronic hepatitis B infection. METHODS: The authors present

three case studies wherein multiple crossovers of daily thiamine

administration were used to evaluate a hypothesized association between

thiamine treatment and aminotransferase levels. RESULTS: In each case study,

thiamine administration was associated with reduction in aminotransferase

levels and the fall of HBV DNA to undetectable levels. Analyses by t test

demonstrated a statistically significant reduction in aminotransferase

levels in all three cases. CONCLUSIONS: The relationship between thiamine

administration and chronic hepatitis B infection warrants further study. If

proven effective in reducing liver damage or inducing remission of the

hepatitis B virus in larger trials, thiamine will offer obvious advantages

over the current treatments for chronic viral hepatitis B infection.

PMID: 11280566