Vertical transmission of hepatitis C virus

[Guest guest]

1: An Esp Pediatr 2001 Jan;54(1):27-31

[Vertical transmission of hepatitis C virus].

[Article in Spanish]

Rubio Quevedo C, Holgado Carballo MA, Suarez A, de Lara IM,

Molto Ripoll L.

Servicio de Pediatria. Hospital MaternoInfantil Virgen de las Nieves.

Granada. claudiorq@...

OBJECTIVES: Few studies have been published on vertical transmission of

hepatitis C virus (HCV), although it is the most common cause of hepatitis C

in children. We aimed to determine the rate of vertical transmission of HCV

in at risk neonates and to assess the effect of possible risk factors.

METHODS: A prospective follow-up study was conducted in 35 children of

seropositive mothers during an 18-month period (July 1997-January 1999).

Testing for anti-HCV antibodies was performed with third generation enzyme

linked immunoadsorbent assay. HCV-RNA was qualitatively analyzed with

reverse transcriptase polymerase chain reaction (RT-PCR) and hepatic enzyme

studies. RESULTS: All the 35 children studied were positive for HCV

antibodies at birth. The children became HCV negative at a mean age of 6

months. HCV infection was detected in two children (5.7%). The mother of one

of these children had both HCV and human immunodeficiency virus (HIV)

infection. Among the 35 seropositive mothers, a risk factor for percutaneous

transmission of HCV (parenteral injection, drug addiction, or previous

transfusions) was detected in 19(54%) and HIV coinfection was found in

9(26%). CONCLUSIONS: The present study is consistent with other studies that

found a vertical HCV transmission rate of approximately 5%, with a greater

risk if the mothers had HCV/HIV coinfection or parenteral risk factors.

Studies with greater numbers of subjects are required to determine the

prevalence of HCV in expectant mothers and the precise rate of vertical

transmission. Infected children should be followed up to evaluate the

repercussions of HCV infection.

PMID: 11181191 [PubMed - indexed for MEDLINE]

[Guest guest]

1: An Esp Pediatr 2001 Jan;54(1):27-31

[Vertical transmission of hepatitis C virus].

[Article in Spanish]

Rubio Quevedo C, Holgado Carballo MA, Suarez A, de Lara IM,

Molto Ripoll L.

Servicio de Pediatria. Hospital MaternoInfantil Virgen de las Nieves.

Granada. claudiorq@...

OBJECTIVES: Few studies have been published on vertical transmission of

hepatitis C virus (HCV), although it is the most common cause of hepatitis C

in children. We aimed to determine the rate of vertical transmission of HCV

in at risk neonates and to assess the effect of possible risk factors.

METHODS: A prospective follow-up study was conducted in 35 children of

seropositive mothers during an 18-month period (July 1997-January 1999).

Testing for anti-HCV antibodies was performed with third generation enzyme

linked immunoadsorbent assay. HCV-RNA was qualitatively analyzed with

reverse transcriptase polymerase chain reaction (RT-PCR) and hepatic enzyme

studies. RESULTS: All the 35 children studied were positive for HCV

antibodies at birth. The children became HCV negative at a mean age of 6

months. HCV infection was detected in two children (5.7%). The mother of one

of these children had both HCV and human immunodeficiency virus (HIV)

infection. Among the 35 seropositive mothers, a risk factor for percutaneous

transmission of HCV (parenteral injection, drug addiction, or previous

transfusions) was detected in 19(54%) and HIV coinfection was found in

9(26%). CONCLUSIONS: The present study is consistent with other studies that

found a vertical HCV transmission rate of approximately 5%, with a greater

risk if the mothers had HCV/HIV coinfection or parenteral risk factors.

Studies with greater numbers of subjects are required to determine the

prevalence of HCV in expectant mothers and the precise rate of vertical

transmission. Infected children should be followed up to evaluate the

repercussions of HCV infection.

PMID: 11181191 [PubMed - indexed for MEDLINE]

[Guest guest]

1: An Esp Pediatr 2001 Jan;54(1):27-31

[Vertical transmission of hepatitis C virus].

[Article in Spanish]

Rubio Quevedo C, Holgado Carballo MA, Suarez A, de Lara IM,

Molto Ripoll L.

Servicio de Pediatria. Hospital MaternoInfantil Virgen de las Nieves.

Granada. claudiorq@...

OBJECTIVES: Few studies have been published on vertical transmission of

hepatitis C virus (HCV), although it is the most common cause of hepatitis C

in children. We aimed to determine the rate of vertical transmission of HCV

in at risk neonates and to assess the effect of possible risk factors.

METHODS: A prospective follow-up study was conducted in 35 children of

seropositive mothers during an 18-month period (July 1997-January 1999).

Testing for anti-HCV antibodies was performed with third generation enzyme

linked immunoadsorbent assay. HCV-RNA was qualitatively analyzed with

reverse transcriptase polymerase chain reaction (RT-PCR) and hepatic enzyme

studies. RESULTS: All the 35 children studied were positive for HCV

antibodies at birth. The children became HCV negative at a mean age of 6

months. HCV infection was detected in two children (5.7%). The mother of one

of these children had both HCV and human immunodeficiency virus (HIV)

infection. Among the 35 seropositive mothers, a risk factor for percutaneous

transmission of HCV (parenteral injection, drug addiction, or previous

transfusions) was detected in 19(54%) and HIV coinfection was found in

9(26%). CONCLUSIONS: The present study is consistent with other studies that

found a vertical HCV transmission rate of approximately 5%, with a greater

risk if the mothers had HCV/HIV coinfection or parenteral risk factors.

Studies with greater numbers of subjects are required to determine the

prevalence of HCV in expectant mothers and the precise rate of vertical

transmission. Infected children should be followed up to evaluate the

repercussions of HCV infection.

PMID: 11181191 [PubMed - indexed for MEDLINE]

[Guest guest]

1: An Esp Pediatr 2001 Jan;54(1):27-31

[Vertical transmission of hepatitis C virus].

[Article in Spanish]

Rubio Quevedo C, Holgado Carballo MA, Suarez A, de Lara IM,

Molto Ripoll L.

Servicio de Pediatria. Hospital MaternoInfantil Virgen de las Nieves.

Granada. claudiorq@...

OBJECTIVES: Few studies have been published on vertical transmission of

hepatitis C virus (HCV), although it is the most common cause of hepatitis C

in children. We aimed to determine the rate of vertical transmission of HCV

in at risk neonates and to assess the effect of possible risk factors.

METHODS: A prospective follow-up study was conducted in 35 children of

seropositive mothers during an 18-month period (July 1997-January 1999).

Testing for anti-HCV antibodies was performed with third generation enzyme

linked immunoadsorbent assay. HCV-RNA was qualitatively analyzed with

reverse transcriptase polymerase chain reaction (RT-PCR) and hepatic enzyme

studies. RESULTS: All the 35 children studied were positive for HCV

antibodies at birth. The children became HCV negative at a mean age of 6

months. HCV infection was detected in two children (5.7%). The mother of one

of these children had both HCV and human immunodeficiency virus (HIV)

infection. Among the 35 seropositive mothers, a risk factor for percutaneous

transmission of HCV (parenteral injection, drug addiction, or previous

transfusions) was detected in 19(54%) and HIV coinfection was found in

9(26%). CONCLUSIONS: The present study is consistent with other studies that

found a vertical HCV transmission rate of approximately 5%, with a greater

risk if the mothers had HCV/HIV coinfection or parenteral risk factors.

Studies with greater numbers of subjects are required to determine the

prevalence of HCV in expectant mothers and the precise rate of vertical

transmission. Infected children should be followed up to evaluate the

repercussions of HCV infection.

PMID: 11181191 [PubMed - indexed for MEDLINE]