Jump to content
RemedySpot.com

HEP EXPRESS #23

Rate this topic


Guest guest

Recommended Posts

>

> HEP EXPRESS

> Viral hepatitis news from the Immunization Action Coalition

>

> Combined Federal Campaign #0233

> Federal employees, including military, may contribute

> to IAC by using code #0233 on their pledge cards.

> ===========================================================

> Issue Number 23 November 18, 2004

>

> CONTENTS OF THIS ISSUE

>

> 1. CDC reports 89% decrease in acute hepatitis B infection

> among U.S. children and adolescents during 1990-2002

> 2. VIS translations: New hepatitis A vaccine VIS now

> available in eight additional languages

> 3. CDC creates viral hepatitis slide show for high school

> students

> 4. New York initiative provides free hepatitis B vaccine to

> hospitals adopting a universal birth dose policy

> 5. Report on Illinois hospital practices related to

> hepatitis B birth dose available online

> 6. CDC issues notice about false-positive HBsAg tests

> 7. Updated: IAC revises two hepatitis-related education

> pieces

> 8. October issue of " Vaccinate Adults " is on the Web

> 9. New issue of " Viral Hepatitis " available on VHPB website

> ----------------------------------------------------------------

>

> ABBREVIATIONS: ACIP, Advisory Committee on Immunization

> Practices; CDC, Centers for Disease Control and Prevention; DVH,

> Division of Viral Hepatitis; HAV, hepatitis A virus; HBV,

> hepatitis B virus; HCV, hepatitis C virus; IAC, Immunization

> Action Coalition; IDU, injection drug user; MMWR, Morbidity and

> Mortality Weekly Report; MSM, men who have sex with men; STD,

> sexually transmitted disease; VIS, Vaccine Information

> Statement; WHO, World Health Organization.

> ----------------------------------------------------------------

>

> (1 of 9)

> November 18, 2004

> CDC REPORTS 89% DECREASE IN ACUTE HEPATITIS B INFECTION AMONG

> U.S. CHILDREN AND ADOLESCENTS DURING 1990-2002

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/8/04.]

>

> CDC published " Acute Hepatitis B Among Children and Adolescents

> --United States, 1990-2002 " in the November 5 issue of MMWR. The

> article is reprinted below in its entirety, excluding

> references, two figures, and a table.

>

> ***********************

>

> Since the 1991 adoption of a comprehensive strategy to eliminate

> hepatitis B virus (HBV) transmission in the United States, the

> incidence of acute hepatitis B cases has declined steadily.

> Declines have been greatest among children born after the 1991

> recommendations for universal infant hepatitis B vaccination

> were implemented. In 1995, the elimination strategy was expanded

> to include routine vaccination of all adolescents aged 11-12

> years and, in 1999, to include children aged <18 years who had

> not been vaccinated previously. To describe the epidemiology of

> acute hepatitis B in children and adolescents in the United

> States, CDC analyzed notifiable disease surveillance data

> collected during 1990-2002 and data collected during 2001-2002

> through enhanced surveillance of reported cases of acute

> hepatitis B in children born after 1990. This report summarizes

> the results of that analysis, which indicated that the rate of

> acute hepatitis B in children and adolescents decreased 89%

> during 1990-2002 and that racial disparities in hepatitis B

> incidence have narrowed. Many confirmed cases in persons born

> after 1990 occurred among international adoptees and other

> children born outside the United States. Continued

> implementation of the hepatitis B elimination strategy and

> accurate surveillance data to monitor the impact of vaccination

> are necessary to sustain the decline of acute hepatitis B among

> children.

>

> Cases of acute hepatitis B were reported weekly to CDC by all 50

> states and the District of Columbia. Acute hepatitis B rates

> were calculated per 100,000 population by using population

> denominators from the U.S. Census Bureau. Acute hepatitis B was

> defined as an acute illness with (1) discrete onset of symptoms

> and jaundice or elevated serum aminotransferase levels and (2)

> laboratory evidence of either IgM antibody to hepatitis B core

> antigen (IgM anti-HBc) or hepatitis B surface antigen (HBsAg).

> Since March 2001, CDC has conducted enhanced hepatitis B

> surveillance, contacting states to confirm all reported cases of

> acute hepatitis B in persons born after 1990. State surveillance

> staff members were asked to verify each of the items in the case

> definition and provide information regarding vaccination history

> and country of birth. If errors were identified during this

> process, states were asked to correct the information in an

> updated submission to CDC.

>

> National Surveillance

> During 1990-2002, a total of 13,829 cases of acute hepatitis B

> were reported in the United States among persons aged <=19

> years. The incidence of reported cases declined steadily during

> this period, from 3.03 per 100,000 population in 1990 to 0.34 in

> 2002, representing a decline of 89%. The incidence among

> adolescents aged 15-19 years was consistently higher than the

> incidence among younger age groups, ranging from 8.69 per

> 100,000 population in 1990 to 1.13 in 2002. Children and

> adolescents in all age groups experienced steep declines in

> incidence during 1990-2002; incidence declined 94% among

> children aged 0-4 years, 92% among children aged 5-9 years,

> 93% among those aged 10-14 years, and 87% among adolescents aged

> 15-19 years.

>

> Among children and adolescents aged <=19 years in 1990,

> incidence per 100,000 population was highest among Asian/Pacific

> Islanders (A/PIs) (6.74) and blacks (4.29); whites had the

> lowest race-specific incidence (1.39). Differences in incidence

> between whites and A/PIs and between whites and blacks were 5.34

> and 2.90, respectively. From 1990 to 2002, rates declined 92%

> among A/PIs, 88% among whites, 88% among blacks, and 84% among

> American Indians/Alaskan Natives (AI/ANs). In 2002, the highest

> incidence per 100,000 population was among A/PIs (0.55),

> followed by blacks (0.51), AI/ANs (0.43), and whites (0.16);

> since 1990, differences in incidence between whites and A/PIs

> and whites and blacks declined by 93% and 88%, respectively.

>

> Case Investigations

> Follow-up investigations conducted by CDC and state and local

> health departments verified 19 case reports from 2001 and 2002

> as cases of acute hepatitis B among children born after 1990. Of

> the verified case reports, 12 (60%) involved males, eight (42%)

> involved children aged <2 years, and 11 (58%) involved children

> born in the United States. Seven (37%) reported race as A/PI,

> five (26%) as white, four (21%) as black, and three (16%) as

> unknown. Eight (42%) cases were reported in children born

> outside the United States, including six international adoptees

> (32%). Receipt of >=1 dose of hepatitis B vaccine was confirmed

> in three (16%) cases. Vaccination status was unknown for 12

> cases (63%).

>

> Editorial Note:

> The incidence of acute hepatitis B cases in U.S. children and

> adolescents decreased during the era of universal childhood

> vaccination. This decline coincided with an increase in

> hepatitis B vaccination coverage among children aged 19-35

> months, from 16% in 1992 to 90% in 2002, and among adolescents

> aged 13-15, from nearly 0 in 1992 to 67% in 2002.

>

> Declines in incidence were observed for children of all races,

> including A/PIs, whose rates historically have been higher than

> the national average. Because of the disproportionate burden of

> hepatitis B in A/PI communities, A/PI children were among the

> first groups for whom hepatitis B vaccination was recommended.

> The reduction of the disparity between A/PIs and other children

> is consistent with recent observations noting a decline in

> seroprevalence of HBV infection and successful implementation of

> routine hepatitis B vaccination among Asians who have recently

> immigrated to the United States. However, of the 11 verified

> cases during 2001-02 of acute hepatitis B among children born in

> the United States, three (27%) involved A/PIs. Although the

> national origins of these children's household members are

> unknown, the substantial proportion of A/PIs suggests that

> horizontal transmission of HBV among first-generation Asians

> might be a persistent problem.

>

> The higher incidence among older adolescents (aged 15-19 years)

> likely is attributable to their having been born before

> universal infant hepatitis B vaccination was recommended in

> 1991. Incidence among older adolescents is expected to decline

> further as the vaccinated cohort ages and as 1999

> recommendations to vaccinate all previously unvaccinated persons

> aged 0-18 years are fully implemented. The expected decline in

> rates among adolescents also might be augmented by laws in 32

> states requiring proof of hepatitis B vaccination before entry

> into middle school.

>

> Follow-up information obtained through surveillance of reported

> cases suggests that children born outside the United States,

> especially international adoptees, represent a substantial

> proportion of cases. Cases of acute hepatitis B among

> international adoptees might result from undervaccination and

> increased risk for exposure while living in areas with high

> prevalence of chronic HBV infection. International adoptees are

> exempt from U.S. regulations that bar entry to immigrants

> without documentation of hepatitis B vaccination. Studies have

> demonstrated that international adoptees exhibit low rates of

> protective titers of antibodies to vaccine-preventable diseases

> upon arrival in the United States, including adoptees with

> written evidence of age-appropriate vaccination provided by the

> birth country. Appropriate evaluation and remediation of the

> immunization status of international adoptees has been promoted

> through national guidelines; however, the extent to which these

> guidelines have been implemented is unknown.

>

> Despite the decline in acute hepatitis B cases among children in

> the United States, the presence of confirmed cases highlights

> the importance of infant vaccination and timely completion of

> the 3-dose vaccination series. The vaccination series should be

> started at birth, preferably before the newborn is discharged

> from the hospital. Infants born to women who are HBsAg positive

> or who have not had prenatal HBsAg testing should receive the

> first dose of hepatitis B vaccine within 12 hours of birth.

> Beginning the vaccination series at birth decreases the risk for

> perinatal HBV transmission and predicts successful completion of

> the series.

>

> Although enhanced surveillance data from verified case reports

> suggest that international adoptees and other children born

> outside the United States might particularly benefit from future

> prevention efforts, many case reports lacked risk factor

> information. As the incidence of acute hepatitis B among

> children and adolescents declines, accurate surveillance data

> become increasingly important to monitor the effect of

> immunization recommendations. Continued efforts of local, state,

> and national surveillance staff to improve data quality are

> critical to eliminating HBV transmission in the United States.

>

> ***********************

>

> To access a web-text (HTML) version of the complete article,

> go to: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5343a4.htm

>

> To access a ready-to-copy (PDF) version of this issue of MMWR,

> go to: http://www.cdc.gov/mmwr/PDF/wk/mm5343.pdf

>

> To receive a FREE electronic subscription to MMWR, go to:

> http://www.cdc.gov/mmwr/mmwrsubscribe.html

> ----------------------------------------------------------------

>

> (2 of 9)

> November 18, 2004

> VIS TRANSLATIONS: NEW HEPATITIS A VACCINE VIS NOW AVAILABLE IN

> EIGHT ADDITIONAL LANGUAGES

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/1/04.]

>

> Dated 8/4/04, the current version of the VIS for hepatitis A

> vaccine is now available on the IAC website in eight additional

> languages: Arabic, Armenian, Cambodian, Farsi, Haitian Creole,

> Hmong, Korean, and Vietnamese. IAC gratefully acknowledges the

> Massachusetts Department of Public Health for the Haitian Creole

> translation and the California Department of Health Services for

> the remaining translations.

>

> PLEASE NOTE: When hepatitis A vaccine is added to the Vaccine

> Injury Compensation Program's injury table, presumably later in

> 2004, another hepatitis A vaccine VIS will be issued. To avoid

> large printing expenses, print off only as many of the 8/4/04

> VISs as you anticipate needing for the next several months.

>

> To obtain a ready-to-copy (PDF) version of the VIS for hepatitis

> A vaccine in ARABIC, go to:

> http://www.immunize.org/vis/ab_hpa04.pdf

>

> To obtain it in ARMENIAN, go to:

> http://www.immunize.org/vis/ar_hpa04.pdf

>

> To obtain it in CAMBODIAN, go to:

> http://www.immunize.org/vis/ca_hpa04.pdf

>

> To obtain it in FARSI, go to:

> http://www.immunize.org/vis/fa_hpa04.pdf

>

> To obtain it in HAITIAN CREOLE, go to:

> http://www.immunize.org/vis/ha_hpa04.pdf

>

> To obtain it in HMONG, go to:

> http://www.immunize.org/vis/hm_hpa04.pdf

>

> To obtain it in KOREAN, go to:

> http://www.immunize.org/vis/ko_hpa04.pdf

>

> To obtain it in VIETNAMESE, go to:

> http://www.immunize.org/vis/vn_hpa04.pdf

>

> To obtain it in ENGLISH, go to:

> http://www.immunize.org/vis/v-hepa.pdf

>

> For information about the use of VISs, and for VISs in a total

> of 32 languages, visit IAC's VIS web section at

> http://www.immunize.org/vis

> ----------------------------------------------------------------

>

> (3 of 9)

> November 18, 2004

> CDC CREATES VIRAL HEPATITIS SLIDE SHOW FOR HIGH SCHOOL STUDENTS

>

> CDC's Division of Viral Hepatitis has developed a three-part

> slide set for high school students, designed to give adolescents

> basic information and raise awareness about HAV, HBV, and HCV.

> The set can be used as a resource for science or health

> projects, as an outline for a teaching tool, or as reference

> material to inform others (e.g., family, friends).

>

> To view or download this resource, go to:

> http://www.cdc.gov/ncidod/diseases/hepatitis/resource/training/hs_slideset.htm

> ----------------------------------------------------------------

>

> (4 of 9)

> November 18, 2004

> NEW YORK INITIATIVE PROVIDES FREE HEPATITIS B VACCINE TO

> HOSPITALS ADOPTING A UNIVERSAL BIRTH DOSE POLICY

>

> The Hepatitis B Birth Dose Program is an initiative of the New

> York State Department of Health (NYSDOH) that provides free

> hepatitis B vaccine to any birthing hospital in New York State

> that agrees to adopt a universal hepatitis B birth dose policy.

> Since October 2003, the program has enrolled 50 (out of 113)

> upstate and 25 (out of 45) New York City birthing hospitals.

>

> Hospitals may participate in the program by submitting a brief

> application, along with their birth dose policy, to NYSDOH for

> review. The policy must clearly show that all newborns will be

> routinely vaccinated against hepatitis B at birth regardless of

> maternal hepatitis B surface antigen status, infant's insurance

> status, or individual physician preference.

>

> The provision of hepatitis B vaccine to all infants at birth

> provides a safety net to high-risk infants who do not receive

> appropriate prophylactic treatment against HBV transmission at

> birth, and to infants who are exposed to HBV postnatally from

> another family member or caregiver.

>

> In a 2002 survey of New York State birthing hospitals, cost of

> vaccine was identified as a barrier to vaccinating infants at

> birth by many hospitals. Through this new program, NYSDOH hopes

> to eliminate additional hospital costs for vaccine purchase

> while improving hospital compliance with recommended standards

> of care.

>

> Questions regarding the program can be directed to Perinatal

> Hepatitis B Program Manager Herlihy, RN, MS, at

> (518) 473-4437 or EJH04@...

> ----------------------------------------------------------------

>

> (5 of 9)

> November 18, 2004

> REPORT ON ILLINOIS HOSPITAL PRACTICES RELATED TO HEPATITIS B

> BIRTH DOSE AVAILABLE ONLINE

>

> The Illinois Chapter of the American Academy of Pediatrics (AAP)

> and the Illinois Department of Public Health collaborated on a

> study titled: " Report of Illinois Birthing Hospital Practices

> with Respect to the Administration of the Hepatitis B Birth Dose

> Vaccine and Hospital Participation in the Vaccines for Children-

> Plus Program. "

>

> The first four study objectives were

>

> (1) Assess Illinois birthing hospital practices and policies

> with respect to administration of the hepatitis B vaccine

> to newborns prior to hospital discharge.

> (2) Identify strategies to increase the hepatitis B birth

> dose vaccination rate in Illinois.

> (3) Determine how many Illinois birthing hospitals are

> currently enrolled in the Vaccines for Children-Plus

> (VFC-Plus) program. [VFC-Plus provides hospitals with

> vaccines, such as that for hepatitis B, for children who

> do not have insurance or for whom private insurance will

> not pay.]

> (4) Identify factors impacting enrollment/non-enrollment into

> the VFC-Plus program.

>

> The study found that the establishment of hospital policies, and

> more importantly, written standing orders for administration of

> the hepatitis B birth dose correlated with significantly higher

> hepatitis B birth dose administration rates. Hospitals enrolled

> in the Illinois VFC-Plus program demonstrated significantly

> higher hepatitis B birth dose vaccination rates when compared

> with non-enrolled hospitals.

>

> The study is an excellent example of collaboration between a

> state public health department and the state AAP chapter and can

> be used to stimulate discussion and planning in other states.

>

> To read the report online, go to:

> http://www.illinoisaap.org/HepBFinalReport.pdf

> ----------------------------------------------------------------

>

> (6 of 9)

> November 18, 2004

> CDC ISSUES NOTICE ABOUT FALSE-POSITIVE HBsAg TESTS

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/1/04.]

>

> CDC recently posted the following notice on the Viral Hepatitis

> section of the National Center for Infectious Diseases' (NCID)

> website.

>

> *********************

>

> FALSE-POSITIVE HBsAg TESTS NOTED

>

> BD and Abbott Diagnostics have initiated an investigation

> concerning the increased rate of initial and/or repeat reactive

> results for the AUSZYME Monoclonal test when using BD Vacutainer

> SST Plus tubes. As described in the AUSZYME package insert,

> reactive specimens should be repeated in duplicate. If either of

> the repeats is positive, the sample should then be tested with a

> licensed neutralizing confirmatory test, such as the HBsAg

> Confirmatory Assay. Only those specimens in which the HBsAg can

> be neutralized by the confirmatory test procedure may be

> designated as positive for HBsAg. All highly sensitive

> immunoassay systems have a potential for nonspecific reactions.

> The specificity of a repeatedly reactive specimen can be

> confirmed by neutralization tests.

>

> *********************

>

> To access the notice, go to:

> http://www.cdc.gov/ncidod/diseases/hepatitis/new.htm#top Click

> on the link titled " False positive HBsAg tests noted. "

>

> For additional technical or product-related information, read

> the BD technical bulletin at

>

http://www.bd.com/vacutainer/pdfs/techbulletins/Abbott_Diagnostics_17september20\

04.pdf

>

> If you have identified a cluster of infants born to false-

> positive HBsAg mothers, who because of the false-positive

> results, have been monitored as if they were born to HBsAg-

> positive mothers, please call A. Wang, MD, MPH, at NCID

> at (404) 371-5953.

> ----------------------------------------------------------------

>

> (7 of 9)

> November 18, 2004

> UPDATED: IAC REVISES TWO HEPATITIS-RELATED EDUCATION PIECES

>

> IAC recently revised two of its long-standing hepatitis B

> education pieces.

>

> " Hepatitis B Shots Are Recommended for All New Babies " is a

> brochure targeted at expectant or new parents who might question

> the need for, or timing of, infant vaccination against HBV.

>

> To access a ready-to-copy (PDF) version of " Hepatitis B Shots

> Are Recommended for All New Babies, " go to:

> http://www.immunize.org/catg.d/p4110bab.pdf

>

> To access a web-text (HTML) version of it, go to:

> http://www.immunize.org/catg.d/p4110bab.htm

>

> " Hepatitis B Information for Asian and Pacific Islander

> Americans " was created to answer the questions of Asian and

> Pacific Islander Americans (APIA), including immigrants and

> refugees, as well as persons of APIA descent born in the United

> States. The revised version includes an updated list of related

> organizations that readers might wish to contact.

>

> To access a ready-to-copy (PDF) version of " Hepatitis B

> Information for Asian and Pacific Islander Americans, " go to:

> http://www.immunize.org/catg.d/4190apia.pdf

>

> To access a web-text (HTML) version of it, go to:

> http://www.immunize.org/catg.d/4190apia.htm

> ----------------------------------------------------------------

>

> (8 of 9)

> November 18, 2004

> OCTOBER ISSUE OF " VACCINATE ADULTS " IS ON THE WEB

>

> IAC recently mailed the latest issue of " VACCINATE ADULTS "

> (October 2004) to 100,000 health professionals and others who

> work in the field of immunization. Packed with immunization

> resources for health professionals and patients, the 12-page

> issue is well worth downloading. All articles and education

> pieces, except editorials, have been thoroughly reviewed by

> immunization and hepatitis experts at CDC.

>

> PLEASE NOTE: Current as of September 2004, the resources in the

> October " VACCINATE ADULTS " do not contain the most recent

> information on influenza vaccine and vaccine supply. On October

> 5, ACIP developed interim influenza vaccine recommendations in

> response to Chiron Corporation's announcement that its trivalent

> inactivated influenza vaccine will not be available in the

> United States for the 2004-05 influenza season. The information

> in the interim recommendations is not reflected in any of the

> influenza information published in the October " VACCINATE

> ADULTS. "

>

> HOW TO READ " VACCINATE ADULTS " ON THE WEB

> You can view selected articles from the table of contents below

> or download the entire issue from the Web.

>

> To view the table of contents with links to individual articles,

> go to:

> http://www.immunize.org/va

>

> The PDF file of the entire issue, linked below, is large at

> 608,197 bytes. Some printers cannot print such a large file. For

> tips on downloading and printing PDF files, go to:

> http://www.immunize.org/nslt.d/tips.htm

>

> To download a ready-to-copy (PDF) version of the October issue,

> go to: http://www.immunize.org/va/va14.pdf

> ----------------------------------------------------------------

>

> (9 of 9)

> November 18, 2004

> NEW ISSUE OF " VIRAL HEPATITIS " AVAILABLE ON VHPB WEBSITE

>

> The Viral Hepatitis Prevention Board (VHPB) website has been

> updated to include a new issue of the publication " Viral

> Hepatitis. "

>

> " Viral Hepatitis, " Volume 13, Number 1, is prepared from

> material presented at the VHPB meeting on March 11-12, 2004, in

> Sevilla, Spain. The topic of this meeting was " Hepatitis B

> vaccine: long-term efficacy, booster policy, and impact of HBV

> mutants on hepatitis B vaccination programmes. "

>

> To access the ready-to-copy (PDF) versions of this issue,

> go to: http://www.vhpb.org/Default.asp?navItem=newsletters

>

> To access the home page of the VHPB website, go to:

> http://www.vhpb.org

>

> ===================================================================

> We hope you will forward this e-newsletter to others.

>

> Managing editor: A. , DDS, MPH

> Copy editor: Dale

> Editorial assistant: Janelle Tangonan

> ISSN: 1547-6375

>

> To subscribe or change your HEP EXPRESS email address, or to view

> past issues, please visit http://www.hepprograms.org/hepexpress

>

> This publication is supported by Grant No. U50/CCU523259 from

> the Division of Viral Hepatitis at the Centers for Disease Control

> and Prevention. Its contents are solely the responsibility of IAC

> and do not necessarily represent the official views of CDC.

> Circulation: 1,951

>

>

Link to comment
Share on other sites

>

> HEP EXPRESS

> Viral hepatitis news from the Immunization Action Coalition

>

> Combined Federal Campaign #0233

> Federal employees, including military, may contribute

> to IAC by using code #0233 on their pledge cards.

> ===========================================================

> Issue Number 23 November 18, 2004

>

> CONTENTS OF THIS ISSUE

>

> 1. CDC reports 89% decrease in acute hepatitis B infection

> among U.S. children and adolescents during 1990-2002

> 2. VIS translations: New hepatitis A vaccine VIS now

> available in eight additional languages

> 3. CDC creates viral hepatitis slide show for high school

> students

> 4. New York initiative provides free hepatitis B vaccine to

> hospitals adopting a universal birth dose policy

> 5. Report on Illinois hospital practices related to

> hepatitis B birth dose available online

> 6. CDC issues notice about false-positive HBsAg tests

> 7. Updated: IAC revises two hepatitis-related education

> pieces

> 8. October issue of " Vaccinate Adults " is on the Web

> 9. New issue of " Viral Hepatitis " available on VHPB website

> ----------------------------------------------------------------

>

> ABBREVIATIONS: ACIP, Advisory Committee on Immunization

> Practices; CDC, Centers for Disease Control and Prevention; DVH,

> Division of Viral Hepatitis; HAV, hepatitis A virus; HBV,

> hepatitis B virus; HCV, hepatitis C virus; IAC, Immunization

> Action Coalition; IDU, injection drug user; MMWR, Morbidity and

> Mortality Weekly Report; MSM, men who have sex with men; STD,

> sexually transmitted disease; VIS, Vaccine Information

> Statement; WHO, World Health Organization.

> ----------------------------------------------------------------

>

> (1 of 9)

> November 18, 2004

> CDC REPORTS 89% DECREASE IN ACUTE HEPATITIS B INFECTION AMONG

> U.S. CHILDREN AND ADOLESCENTS DURING 1990-2002

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/8/04.]

>

> CDC published " Acute Hepatitis B Among Children and Adolescents

> --United States, 1990-2002 " in the November 5 issue of MMWR. The

> article is reprinted below in its entirety, excluding

> references, two figures, and a table.

>

> ***********************

>

> Since the 1991 adoption of a comprehensive strategy to eliminate

> hepatitis B virus (HBV) transmission in the United States, the

> incidence of acute hepatitis B cases has declined steadily.

> Declines have been greatest among children born after the 1991

> recommendations for universal infant hepatitis B vaccination

> were implemented. In 1995, the elimination strategy was expanded

> to include routine vaccination of all adolescents aged 11-12

> years and, in 1999, to include children aged <18 years who had

> not been vaccinated previously. To describe the epidemiology of

> acute hepatitis B in children and adolescents in the United

> States, CDC analyzed notifiable disease surveillance data

> collected during 1990-2002 and data collected during 2001-2002

> through enhanced surveillance of reported cases of acute

> hepatitis B in children born after 1990. This report summarizes

> the results of that analysis, which indicated that the rate of

> acute hepatitis B in children and adolescents decreased 89%

> during 1990-2002 and that racial disparities in hepatitis B

> incidence have narrowed. Many confirmed cases in persons born

> after 1990 occurred among international adoptees and other

> children born outside the United States. Continued

> implementation of the hepatitis B elimination strategy and

> accurate surveillance data to monitor the impact of vaccination

> are necessary to sustain the decline of acute hepatitis B among

> children.

>

> Cases of acute hepatitis B were reported weekly to CDC by all 50

> states and the District of Columbia. Acute hepatitis B rates

> were calculated per 100,000 population by using population

> denominators from the U.S. Census Bureau. Acute hepatitis B was

> defined as an acute illness with (1) discrete onset of symptoms

> and jaundice or elevated serum aminotransferase levels and (2)

> laboratory evidence of either IgM antibody to hepatitis B core

> antigen (IgM anti-HBc) or hepatitis B surface antigen (HBsAg).

> Since March 2001, CDC has conducted enhanced hepatitis B

> surveillance, contacting states to confirm all reported cases of

> acute hepatitis B in persons born after 1990. State surveillance

> staff members were asked to verify each of the items in the case

> definition and provide information regarding vaccination history

> and country of birth. If errors were identified during this

> process, states were asked to correct the information in an

> updated submission to CDC.

>

> National Surveillance

> During 1990-2002, a total of 13,829 cases of acute hepatitis B

> were reported in the United States among persons aged <=19

> years. The incidence of reported cases declined steadily during

> this period, from 3.03 per 100,000 population in 1990 to 0.34 in

> 2002, representing a decline of 89%. The incidence among

> adolescents aged 15-19 years was consistently higher than the

> incidence among younger age groups, ranging from 8.69 per

> 100,000 population in 1990 to 1.13 in 2002. Children and

> adolescents in all age groups experienced steep declines in

> incidence during 1990-2002; incidence declined 94% among

> children aged 0-4 years, 92% among children aged 5-9 years,

> 93% among those aged 10-14 years, and 87% among adolescents aged

> 15-19 years.

>

> Among children and adolescents aged <=19 years in 1990,

> incidence per 100,000 population was highest among Asian/Pacific

> Islanders (A/PIs) (6.74) and blacks (4.29); whites had the

> lowest race-specific incidence (1.39). Differences in incidence

> between whites and A/PIs and between whites and blacks were 5.34

> and 2.90, respectively. From 1990 to 2002, rates declined 92%

> among A/PIs, 88% among whites, 88% among blacks, and 84% among

> American Indians/Alaskan Natives (AI/ANs). In 2002, the highest

> incidence per 100,000 population was among A/PIs (0.55),

> followed by blacks (0.51), AI/ANs (0.43), and whites (0.16);

> since 1990, differences in incidence between whites and A/PIs

> and whites and blacks declined by 93% and 88%, respectively.

>

> Case Investigations

> Follow-up investigations conducted by CDC and state and local

> health departments verified 19 case reports from 2001 and 2002

> as cases of acute hepatitis B among children born after 1990. Of

> the verified case reports, 12 (60%) involved males, eight (42%)

> involved children aged <2 years, and 11 (58%) involved children

> born in the United States. Seven (37%) reported race as A/PI,

> five (26%) as white, four (21%) as black, and three (16%) as

> unknown. Eight (42%) cases were reported in children born

> outside the United States, including six international adoptees

> (32%). Receipt of >=1 dose of hepatitis B vaccine was confirmed

> in three (16%) cases. Vaccination status was unknown for 12

> cases (63%).

>

> Editorial Note:

> The incidence of acute hepatitis B cases in U.S. children and

> adolescents decreased during the era of universal childhood

> vaccination. This decline coincided with an increase in

> hepatitis B vaccination coverage among children aged 19-35

> months, from 16% in 1992 to 90% in 2002, and among adolescents

> aged 13-15, from nearly 0 in 1992 to 67% in 2002.

>

> Declines in incidence were observed for children of all races,

> including A/PIs, whose rates historically have been higher than

> the national average. Because of the disproportionate burden of

> hepatitis B in A/PI communities, A/PI children were among the

> first groups for whom hepatitis B vaccination was recommended.

> The reduction of the disparity between A/PIs and other children

> is consistent with recent observations noting a decline in

> seroprevalence of HBV infection and successful implementation of

> routine hepatitis B vaccination among Asians who have recently

> immigrated to the United States. However, of the 11 verified

> cases during 2001-02 of acute hepatitis B among children born in

> the United States, three (27%) involved A/PIs. Although the

> national origins of these children's household members are

> unknown, the substantial proportion of A/PIs suggests that

> horizontal transmission of HBV among first-generation Asians

> might be a persistent problem.

>

> The higher incidence among older adolescents (aged 15-19 years)

> likely is attributable to their having been born before

> universal infant hepatitis B vaccination was recommended in

> 1991. Incidence among older adolescents is expected to decline

> further as the vaccinated cohort ages and as 1999

> recommendations to vaccinate all previously unvaccinated persons

> aged 0-18 years are fully implemented. The expected decline in

> rates among adolescents also might be augmented by laws in 32

> states requiring proof of hepatitis B vaccination before entry

> into middle school.

>

> Follow-up information obtained through surveillance of reported

> cases suggests that children born outside the United States,

> especially international adoptees, represent a substantial

> proportion of cases. Cases of acute hepatitis B among

> international adoptees might result from undervaccination and

> increased risk for exposure while living in areas with high

> prevalence of chronic HBV infection. International adoptees are

> exempt from U.S. regulations that bar entry to immigrants

> without documentation of hepatitis B vaccination. Studies have

> demonstrated that international adoptees exhibit low rates of

> protective titers of antibodies to vaccine-preventable diseases

> upon arrival in the United States, including adoptees with

> written evidence of age-appropriate vaccination provided by the

> birth country. Appropriate evaluation and remediation of the

> immunization status of international adoptees has been promoted

> through national guidelines; however, the extent to which these

> guidelines have been implemented is unknown.

>

> Despite the decline in acute hepatitis B cases among children in

> the United States, the presence of confirmed cases highlights

> the importance of infant vaccination and timely completion of

> the 3-dose vaccination series. The vaccination series should be

> started at birth, preferably before the newborn is discharged

> from the hospital. Infants born to women who are HBsAg positive

> or who have not had prenatal HBsAg testing should receive the

> first dose of hepatitis B vaccine within 12 hours of birth.

> Beginning the vaccination series at birth decreases the risk for

> perinatal HBV transmission and predicts successful completion of

> the series.

>

> Although enhanced surveillance data from verified case reports

> suggest that international adoptees and other children born

> outside the United States might particularly benefit from future

> prevention efforts, many case reports lacked risk factor

> information. As the incidence of acute hepatitis B among

> children and adolescents declines, accurate surveillance data

> become increasingly important to monitor the effect of

> immunization recommendations. Continued efforts of local, state,

> and national surveillance staff to improve data quality are

> critical to eliminating HBV transmission in the United States.

>

> ***********************

>

> To access a web-text (HTML) version of the complete article,

> go to: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5343a4.htm

>

> To access a ready-to-copy (PDF) version of this issue of MMWR,

> go to: http://www.cdc.gov/mmwr/PDF/wk/mm5343.pdf

>

> To receive a FREE electronic subscription to MMWR, go to:

> http://www.cdc.gov/mmwr/mmwrsubscribe.html

> ----------------------------------------------------------------

>

> (2 of 9)

> November 18, 2004

> VIS TRANSLATIONS: NEW HEPATITIS A VACCINE VIS NOW AVAILABLE IN

> EIGHT ADDITIONAL LANGUAGES

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/1/04.]

>

> Dated 8/4/04, the current version of the VIS for hepatitis A

> vaccine is now available on the IAC website in eight additional

> languages: Arabic, Armenian, Cambodian, Farsi, Haitian Creole,

> Hmong, Korean, and Vietnamese. IAC gratefully acknowledges the

> Massachusetts Department of Public Health for the Haitian Creole

> translation and the California Department of Health Services for

> the remaining translations.

>

> PLEASE NOTE: When hepatitis A vaccine is added to the Vaccine

> Injury Compensation Program's injury table, presumably later in

> 2004, another hepatitis A vaccine VIS will be issued. To avoid

> large printing expenses, print off only as many of the 8/4/04

> VISs as you anticipate needing for the next several months.

>

> To obtain a ready-to-copy (PDF) version of the VIS for hepatitis

> A vaccine in ARABIC, go to:

> http://www.immunize.org/vis/ab_hpa04.pdf

>

> To obtain it in ARMENIAN, go to:

> http://www.immunize.org/vis/ar_hpa04.pdf

>

> To obtain it in CAMBODIAN, go to:

> http://www.immunize.org/vis/ca_hpa04.pdf

>

> To obtain it in FARSI, go to:

> http://www.immunize.org/vis/fa_hpa04.pdf

>

> To obtain it in HAITIAN CREOLE, go to:

> http://www.immunize.org/vis/ha_hpa04.pdf

>

> To obtain it in HMONG, go to:

> http://www.immunize.org/vis/hm_hpa04.pdf

>

> To obtain it in KOREAN, go to:

> http://www.immunize.org/vis/ko_hpa04.pdf

>

> To obtain it in VIETNAMESE, go to:

> http://www.immunize.org/vis/vn_hpa04.pdf

>

> To obtain it in ENGLISH, go to:

> http://www.immunize.org/vis/v-hepa.pdf

>

> For information about the use of VISs, and for VISs in a total

> of 32 languages, visit IAC's VIS web section at

> http://www.immunize.org/vis

> ----------------------------------------------------------------

>

> (3 of 9)

> November 18, 2004

> CDC CREATES VIRAL HEPATITIS SLIDE SHOW FOR HIGH SCHOOL STUDENTS

>

> CDC's Division of Viral Hepatitis has developed a three-part

> slide set for high school students, designed to give adolescents

> basic information and raise awareness about HAV, HBV, and HCV.

> The set can be used as a resource for science or health

> projects, as an outline for a teaching tool, or as reference

> material to inform others (e.g., family, friends).

>

> To view or download this resource, go to:

> http://www.cdc.gov/ncidod/diseases/hepatitis/resource/training/hs_slideset.htm

> ----------------------------------------------------------------

>

> (4 of 9)

> November 18, 2004

> NEW YORK INITIATIVE PROVIDES FREE HEPATITIS B VACCINE TO

> HOSPITALS ADOPTING A UNIVERSAL BIRTH DOSE POLICY

>

> The Hepatitis B Birth Dose Program is an initiative of the New

> York State Department of Health (NYSDOH) that provides free

> hepatitis B vaccine to any birthing hospital in New York State

> that agrees to adopt a universal hepatitis B birth dose policy.

> Since October 2003, the program has enrolled 50 (out of 113)

> upstate and 25 (out of 45) New York City birthing hospitals.

>

> Hospitals may participate in the program by submitting a brief

> application, along with their birth dose policy, to NYSDOH for

> review. The policy must clearly show that all newborns will be

> routinely vaccinated against hepatitis B at birth regardless of

> maternal hepatitis B surface antigen status, infant's insurance

> status, or individual physician preference.

>

> The provision of hepatitis B vaccine to all infants at birth

> provides a safety net to high-risk infants who do not receive

> appropriate prophylactic treatment against HBV transmission at

> birth, and to infants who are exposed to HBV postnatally from

> another family member or caregiver.

>

> In a 2002 survey of New York State birthing hospitals, cost of

> vaccine was identified as a barrier to vaccinating infants at

> birth by many hospitals. Through this new program, NYSDOH hopes

> to eliminate additional hospital costs for vaccine purchase

> while improving hospital compliance with recommended standards

> of care.

>

> Questions regarding the program can be directed to Perinatal

> Hepatitis B Program Manager Herlihy, RN, MS, at

> (518) 473-4437 or EJH04@...

> ----------------------------------------------------------------

>

> (5 of 9)

> November 18, 2004

> REPORT ON ILLINOIS HOSPITAL PRACTICES RELATED TO HEPATITIS B

> BIRTH DOSE AVAILABLE ONLINE

>

> The Illinois Chapter of the American Academy of Pediatrics (AAP)

> and the Illinois Department of Public Health collaborated on a

> study titled: " Report of Illinois Birthing Hospital Practices

> with Respect to the Administration of the Hepatitis B Birth Dose

> Vaccine and Hospital Participation in the Vaccines for Children-

> Plus Program. "

>

> The first four study objectives were

>

> (1) Assess Illinois birthing hospital practices and policies

> with respect to administration of the hepatitis B vaccine

> to newborns prior to hospital discharge.

> (2) Identify strategies to increase the hepatitis B birth

> dose vaccination rate in Illinois.

> (3) Determine how many Illinois birthing hospitals are

> currently enrolled in the Vaccines for Children-Plus

> (VFC-Plus) program. [VFC-Plus provides hospitals with

> vaccines, such as that for hepatitis B, for children who

> do not have insurance or for whom private insurance will

> not pay.]

> (4) Identify factors impacting enrollment/non-enrollment into

> the VFC-Plus program.

>

> The study found that the establishment of hospital policies, and

> more importantly, written standing orders for administration of

> the hepatitis B birth dose correlated with significantly higher

> hepatitis B birth dose administration rates. Hospitals enrolled

> in the Illinois VFC-Plus program demonstrated significantly

> higher hepatitis B birth dose vaccination rates when compared

> with non-enrolled hospitals.

>

> The study is an excellent example of collaboration between a

> state public health department and the state AAP chapter and can

> be used to stimulate discussion and planning in other states.

>

> To read the report online, go to:

> http://www.illinoisaap.org/HepBFinalReport.pdf

> ----------------------------------------------------------------

>

> (6 of 9)

> November 18, 2004

> CDC ISSUES NOTICE ABOUT FALSE-POSITIVE HBsAg TESTS

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/1/04.]

>

> CDC recently posted the following notice on the Viral Hepatitis

> section of the National Center for Infectious Diseases' (NCID)

> website.

>

> *********************

>

> FALSE-POSITIVE HBsAg TESTS NOTED

>

> BD and Abbott Diagnostics have initiated an investigation

> concerning the increased rate of initial and/or repeat reactive

> results for the AUSZYME Monoclonal test when using BD Vacutainer

> SST Plus tubes. As described in the AUSZYME package insert,

> reactive specimens should be repeated in duplicate. If either of

> the repeats is positive, the sample should then be tested with a

> licensed neutralizing confirmatory test, such as the HBsAg

> Confirmatory Assay. Only those specimens in which the HBsAg can

> be neutralized by the confirmatory test procedure may be

> designated as positive for HBsAg. All highly sensitive

> immunoassay systems have a potential for nonspecific reactions.

> The specificity of a repeatedly reactive specimen can be

> confirmed by neutralization tests.

>

> *********************

>

> To access the notice, go to:

> http://www.cdc.gov/ncidod/diseases/hepatitis/new.htm#top Click

> on the link titled " False positive HBsAg tests noted. "

>

> For additional technical or product-related information, read

> the BD technical bulletin at

>

http://www.bd.com/vacutainer/pdfs/techbulletins/Abbott_Diagnostics_17september20\

04.pdf

>

> If you have identified a cluster of infants born to false-

> positive HBsAg mothers, who because of the false-positive

> results, have been monitored as if they were born to HBsAg-

> positive mothers, please call A. Wang, MD, MPH, at NCID

> at (404) 371-5953.

> ----------------------------------------------------------------

>

> (7 of 9)

> November 18, 2004

> UPDATED: IAC REVISES TWO HEPATITIS-RELATED EDUCATION PIECES

>

> IAC recently revised two of its long-standing hepatitis B

> education pieces.

>

> " Hepatitis B Shots Are Recommended for All New Babies " is a

> brochure targeted at expectant or new parents who might question

> the need for, or timing of, infant vaccination against HBV.

>

> To access a ready-to-copy (PDF) version of " Hepatitis B Shots

> Are Recommended for All New Babies, " go to:

> http://www.immunize.org/catg.d/p4110bab.pdf

>

> To access a web-text (HTML) version of it, go to:

> http://www.immunize.org/catg.d/p4110bab.htm

>

> " Hepatitis B Information for Asian and Pacific Islander

> Americans " was created to answer the questions of Asian and

> Pacific Islander Americans (APIA), including immigrants and

> refugees, as well as persons of APIA descent born in the United

> States. The revised version includes an updated list of related

> organizations that readers might wish to contact.

>

> To access a ready-to-copy (PDF) version of " Hepatitis B

> Information for Asian and Pacific Islander Americans, " go to:

> http://www.immunize.org/catg.d/4190apia.pdf

>

> To access a web-text (HTML) version of it, go to:

> http://www.immunize.org/catg.d/4190apia.htm

> ----------------------------------------------------------------

>

> (8 of 9)

> November 18, 2004

> OCTOBER ISSUE OF " VACCINATE ADULTS " IS ON THE WEB

>

> IAC recently mailed the latest issue of " VACCINATE ADULTS "

> (October 2004) to 100,000 health professionals and others who

> work in the field of immunization. Packed with immunization

> resources for health professionals and patients, the 12-page

> issue is well worth downloading. All articles and education

> pieces, except editorials, have been thoroughly reviewed by

> immunization and hepatitis experts at CDC.

>

> PLEASE NOTE: Current as of September 2004, the resources in the

> October " VACCINATE ADULTS " do not contain the most recent

> information on influenza vaccine and vaccine supply. On October

> 5, ACIP developed interim influenza vaccine recommendations in

> response to Chiron Corporation's announcement that its trivalent

> inactivated influenza vaccine will not be available in the

> United States for the 2004-05 influenza season. The information

> in the interim recommendations is not reflected in any of the

> influenza information published in the October " VACCINATE

> ADULTS. "

>

> HOW TO READ " VACCINATE ADULTS " ON THE WEB

> You can view selected articles from the table of contents below

> or download the entire issue from the Web.

>

> To view the table of contents with links to individual articles,

> go to:

> http://www.immunize.org/va

>

> The PDF file of the entire issue, linked below, is large at

> 608,197 bytes. Some printers cannot print such a large file. For

> tips on downloading and printing PDF files, go to:

> http://www.immunize.org/nslt.d/tips.htm

>

> To download a ready-to-copy (PDF) version of the October issue,

> go to: http://www.immunize.org/va/va14.pdf

> ----------------------------------------------------------------

>

> (9 of 9)

> November 18, 2004

> NEW ISSUE OF " VIRAL HEPATITIS " AVAILABLE ON VHPB WEBSITE

>

> The Viral Hepatitis Prevention Board (VHPB) website has been

> updated to include a new issue of the publication " Viral

> Hepatitis. "

>

> " Viral Hepatitis, " Volume 13, Number 1, is prepared from

> material presented at the VHPB meeting on March 11-12, 2004, in

> Sevilla, Spain. The topic of this meeting was " Hepatitis B

> vaccine: long-term efficacy, booster policy, and impact of HBV

> mutants on hepatitis B vaccination programmes. "

>

> To access the ready-to-copy (PDF) versions of this issue,

> go to: http://www.vhpb.org/Default.asp?navItem=newsletters

>

> To access the home page of the VHPB website, go to:

> http://www.vhpb.org

>

> ===================================================================

> We hope you will forward this e-newsletter to others.

>

> Managing editor: A. , DDS, MPH

> Copy editor: Dale

> Editorial assistant: Janelle Tangonan

> ISSN: 1547-6375

>

> To subscribe or change your HEP EXPRESS email address, or to view

> past issues, please visit http://www.hepprograms.org/hepexpress

>

> This publication is supported by Grant No. U50/CCU523259 from

> the Division of Viral Hepatitis at the Centers for Disease Control

> and Prevention. Its contents are solely the responsibility of IAC

> and do not necessarily represent the official views of CDC.

> Circulation: 1,951

>

>

Link to comment
Share on other sites

>

> HEP EXPRESS

> Viral hepatitis news from the Immunization Action Coalition

>

> Combined Federal Campaign #0233

> Federal employees, including military, may contribute

> to IAC by using code #0233 on their pledge cards.

> ===========================================================

> Issue Number 23 November 18, 2004

>

> CONTENTS OF THIS ISSUE

>

> 1. CDC reports 89% decrease in acute hepatitis B infection

> among U.S. children and adolescents during 1990-2002

> 2. VIS translations: New hepatitis A vaccine VIS now

> available in eight additional languages

> 3. CDC creates viral hepatitis slide show for high school

> students

> 4. New York initiative provides free hepatitis B vaccine to

> hospitals adopting a universal birth dose policy

> 5. Report on Illinois hospital practices related to

> hepatitis B birth dose available online

> 6. CDC issues notice about false-positive HBsAg tests

> 7. Updated: IAC revises two hepatitis-related education

> pieces

> 8. October issue of " Vaccinate Adults " is on the Web

> 9. New issue of " Viral Hepatitis " available on VHPB website

> ----------------------------------------------------------------

>

> ABBREVIATIONS: ACIP, Advisory Committee on Immunization

> Practices; CDC, Centers for Disease Control and Prevention; DVH,

> Division of Viral Hepatitis; HAV, hepatitis A virus; HBV,

> hepatitis B virus; HCV, hepatitis C virus; IAC, Immunization

> Action Coalition; IDU, injection drug user; MMWR, Morbidity and

> Mortality Weekly Report; MSM, men who have sex with men; STD,

> sexually transmitted disease; VIS, Vaccine Information

> Statement; WHO, World Health Organization.

> ----------------------------------------------------------------

>

> (1 of 9)

> November 18, 2004

> CDC REPORTS 89% DECREASE IN ACUTE HEPATITIS B INFECTION AMONG

> U.S. CHILDREN AND ADOLESCENTS DURING 1990-2002

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/8/04.]

>

> CDC published " Acute Hepatitis B Among Children and Adolescents

> --United States, 1990-2002 " in the November 5 issue of MMWR. The

> article is reprinted below in its entirety, excluding

> references, two figures, and a table.

>

> ***********************

>

> Since the 1991 adoption of a comprehensive strategy to eliminate

> hepatitis B virus (HBV) transmission in the United States, the

> incidence of acute hepatitis B cases has declined steadily.

> Declines have been greatest among children born after the 1991

> recommendations for universal infant hepatitis B vaccination

> were implemented. In 1995, the elimination strategy was expanded

> to include routine vaccination of all adolescents aged 11-12

> years and, in 1999, to include children aged <18 years who had

> not been vaccinated previously. To describe the epidemiology of

> acute hepatitis B in children and adolescents in the United

> States, CDC analyzed notifiable disease surveillance data

> collected during 1990-2002 and data collected during 2001-2002

> through enhanced surveillance of reported cases of acute

> hepatitis B in children born after 1990. This report summarizes

> the results of that analysis, which indicated that the rate of

> acute hepatitis B in children and adolescents decreased 89%

> during 1990-2002 and that racial disparities in hepatitis B

> incidence have narrowed. Many confirmed cases in persons born

> after 1990 occurred among international adoptees and other

> children born outside the United States. Continued

> implementation of the hepatitis B elimination strategy and

> accurate surveillance data to monitor the impact of vaccination

> are necessary to sustain the decline of acute hepatitis B among

> children.

>

> Cases of acute hepatitis B were reported weekly to CDC by all 50

> states and the District of Columbia. Acute hepatitis B rates

> were calculated per 100,000 population by using population

> denominators from the U.S. Census Bureau. Acute hepatitis B was

> defined as an acute illness with (1) discrete onset of symptoms

> and jaundice or elevated serum aminotransferase levels and (2)

> laboratory evidence of either IgM antibody to hepatitis B core

> antigen (IgM anti-HBc) or hepatitis B surface antigen (HBsAg).

> Since March 2001, CDC has conducted enhanced hepatitis B

> surveillance, contacting states to confirm all reported cases of

> acute hepatitis B in persons born after 1990. State surveillance

> staff members were asked to verify each of the items in the case

> definition and provide information regarding vaccination history

> and country of birth. If errors were identified during this

> process, states were asked to correct the information in an

> updated submission to CDC.

>

> National Surveillance

> During 1990-2002, a total of 13,829 cases of acute hepatitis B

> were reported in the United States among persons aged <=19

> years. The incidence of reported cases declined steadily during

> this period, from 3.03 per 100,000 population in 1990 to 0.34 in

> 2002, representing a decline of 89%. The incidence among

> adolescents aged 15-19 years was consistently higher than the

> incidence among younger age groups, ranging from 8.69 per

> 100,000 population in 1990 to 1.13 in 2002. Children and

> adolescents in all age groups experienced steep declines in

> incidence during 1990-2002; incidence declined 94% among

> children aged 0-4 years, 92% among children aged 5-9 years,

> 93% among those aged 10-14 years, and 87% among adolescents aged

> 15-19 years.

>

> Among children and adolescents aged <=19 years in 1990,

> incidence per 100,000 population was highest among Asian/Pacific

> Islanders (A/PIs) (6.74) and blacks (4.29); whites had the

> lowest race-specific incidence (1.39). Differences in incidence

> between whites and A/PIs and between whites and blacks were 5.34

> and 2.90, respectively. From 1990 to 2002, rates declined 92%

> among A/PIs, 88% among whites, 88% among blacks, and 84% among

> American Indians/Alaskan Natives (AI/ANs). In 2002, the highest

> incidence per 100,000 population was among A/PIs (0.55),

> followed by blacks (0.51), AI/ANs (0.43), and whites (0.16);

> since 1990, differences in incidence between whites and A/PIs

> and whites and blacks declined by 93% and 88%, respectively.

>

> Case Investigations

> Follow-up investigations conducted by CDC and state and local

> health departments verified 19 case reports from 2001 and 2002

> as cases of acute hepatitis B among children born after 1990. Of

> the verified case reports, 12 (60%) involved males, eight (42%)

> involved children aged <2 years, and 11 (58%) involved children

> born in the United States. Seven (37%) reported race as A/PI,

> five (26%) as white, four (21%) as black, and three (16%) as

> unknown. Eight (42%) cases were reported in children born

> outside the United States, including six international adoptees

> (32%). Receipt of >=1 dose of hepatitis B vaccine was confirmed

> in three (16%) cases. Vaccination status was unknown for 12

> cases (63%).

>

> Editorial Note:

> The incidence of acute hepatitis B cases in U.S. children and

> adolescents decreased during the era of universal childhood

> vaccination. This decline coincided with an increase in

> hepatitis B vaccination coverage among children aged 19-35

> months, from 16% in 1992 to 90% in 2002, and among adolescents

> aged 13-15, from nearly 0 in 1992 to 67% in 2002.

>

> Declines in incidence were observed for children of all races,

> including A/PIs, whose rates historically have been higher than

> the national average. Because of the disproportionate burden of

> hepatitis B in A/PI communities, A/PI children were among the

> first groups for whom hepatitis B vaccination was recommended.

> The reduction of the disparity between A/PIs and other children

> is consistent with recent observations noting a decline in

> seroprevalence of HBV infection and successful implementation of

> routine hepatitis B vaccination among Asians who have recently

> immigrated to the United States. However, of the 11 verified

> cases during 2001-02 of acute hepatitis B among children born in

> the United States, three (27%) involved A/PIs. Although the

> national origins of these children's household members are

> unknown, the substantial proportion of A/PIs suggests that

> horizontal transmission of HBV among first-generation Asians

> might be a persistent problem.

>

> The higher incidence among older adolescents (aged 15-19 years)

> likely is attributable to their having been born before

> universal infant hepatitis B vaccination was recommended in

> 1991. Incidence among older adolescents is expected to decline

> further as the vaccinated cohort ages and as 1999

> recommendations to vaccinate all previously unvaccinated persons

> aged 0-18 years are fully implemented. The expected decline in

> rates among adolescents also might be augmented by laws in 32

> states requiring proof of hepatitis B vaccination before entry

> into middle school.

>

> Follow-up information obtained through surveillance of reported

> cases suggests that children born outside the United States,

> especially international adoptees, represent a substantial

> proportion of cases. Cases of acute hepatitis B among

> international adoptees might result from undervaccination and

> increased risk for exposure while living in areas with high

> prevalence of chronic HBV infection. International adoptees are

> exempt from U.S. regulations that bar entry to immigrants

> without documentation of hepatitis B vaccination. Studies have

> demonstrated that international adoptees exhibit low rates of

> protective titers of antibodies to vaccine-preventable diseases

> upon arrival in the United States, including adoptees with

> written evidence of age-appropriate vaccination provided by the

> birth country. Appropriate evaluation and remediation of the

> immunization status of international adoptees has been promoted

> through national guidelines; however, the extent to which these

> guidelines have been implemented is unknown.

>

> Despite the decline in acute hepatitis B cases among children in

> the United States, the presence of confirmed cases highlights

> the importance of infant vaccination and timely completion of

> the 3-dose vaccination series. The vaccination series should be

> started at birth, preferably before the newborn is discharged

> from the hospital. Infants born to women who are HBsAg positive

> or who have not had prenatal HBsAg testing should receive the

> first dose of hepatitis B vaccine within 12 hours of birth.

> Beginning the vaccination series at birth decreases the risk for

> perinatal HBV transmission and predicts successful completion of

> the series.

>

> Although enhanced surveillance data from verified case reports

> suggest that international adoptees and other children born

> outside the United States might particularly benefit from future

> prevention efforts, many case reports lacked risk factor

> information. As the incidence of acute hepatitis B among

> children and adolescents declines, accurate surveillance data

> become increasingly important to monitor the effect of

> immunization recommendations. Continued efforts of local, state,

> and national surveillance staff to improve data quality are

> critical to eliminating HBV transmission in the United States.

>

> ***********************

>

> To access a web-text (HTML) version of the complete article,

> go to: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5343a4.htm

>

> To access a ready-to-copy (PDF) version of this issue of MMWR,

> go to: http://www.cdc.gov/mmwr/PDF/wk/mm5343.pdf

>

> To receive a FREE electronic subscription to MMWR, go to:

> http://www.cdc.gov/mmwr/mmwrsubscribe.html

> ----------------------------------------------------------------

>

> (2 of 9)

> November 18, 2004

> VIS TRANSLATIONS: NEW HEPATITIS A VACCINE VIS NOW AVAILABLE IN

> EIGHT ADDITIONAL LANGUAGES

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/1/04.]

>

> Dated 8/4/04, the current version of the VIS for hepatitis A

> vaccine is now available on the IAC website in eight additional

> languages: Arabic, Armenian, Cambodian, Farsi, Haitian Creole,

> Hmong, Korean, and Vietnamese. IAC gratefully acknowledges the

> Massachusetts Department of Public Health for the Haitian Creole

> translation and the California Department of Health Services for

> the remaining translations.

>

> PLEASE NOTE: When hepatitis A vaccine is added to the Vaccine

> Injury Compensation Program's injury table, presumably later in

> 2004, another hepatitis A vaccine VIS will be issued. To avoid

> large printing expenses, print off only as many of the 8/4/04

> VISs as you anticipate needing for the next several months.

>

> To obtain a ready-to-copy (PDF) version of the VIS for hepatitis

> A vaccine in ARABIC, go to:

> http://www.immunize.org/vis/ab_hpa04.pdf

>

> To obtain it in ARMENIAN, go to:

> http://www.immunize.org/vis/ar_hpa04.pdf

>

> To obtain it in CAMBODIAN, go to:

> http://www.immunize.org/vis/ca_hpa04.pdf

>

> To obtain it in FARSI, go to:

> http://www.immunize.org/vis/fa_hpa04.pdf

>

> To obtain it in HAITIAN CREOLE, go to:

> http://www.immunize.org/vis/ha_hpa04.pdf

>

> To obtain it in HMONG, go to:

> http://www.immunize.org/vis/hm_hpa04.pdf

>

> To obtain it in KOREAN, go to:

> http://www.immunize.org/vis/ko_hpa04.pdf

>

> To obtain it in VIETNAMESE, go to:

> http://www.immunize.org/vis/vn_hpa04.pdf

>

> To obtain it in ENGLISH, go to:

> http://www.immunize.org/vis/v-hepa.pdf

>

> For information about the use of VISs, and for VISs in a total

> of 32 languages, visit IAC's VIS web section at

> http://www.immunize.org/vis

> ----------------------------------------------------------------

>

> (3 of 9)

> November 18, 2004

> CDC CREATES VIRAL HEPATITIS SLIDE SHOW FOR HIGH SCHOOL STUDENTS

>

> CDC's Division of Viral Hepatitis has developed a three-part

> slide set for high school students, designed to give adolescents

> basic information and raise awareness about HAV, HBV, and HCV.

> The set can be used as a resource for science or health

> projects, as an outline for a teaching tool, or as reference

> material to inform others (e.g., family, friends).

>

> To view or download this resource, go to:

> http://www.cdc.gov/ncidod/diseases/hepatitis/resource/training/hs_slideset.htm

> ----------------------------------------------------------------

>

> (4 of 9)

> November 18, 2004

> NEW YORK INITIATIVE PROVIDES FREE HEPATITIS B VACCINE TO

> HOSPITALS ADOPTING A UNIVERSAL BIRTH DOSE POLICY

>

> The Hepatitis B Birth Dose Program is an initiative of the New

> York State Department of Health (NYSDOH) that provides free

> hepatitis B vaccine to any birthing hospital in New York State

> that agrees to adopt a universal hepatitis B birth dose policy.

> Since October 2003, the program has enrolled 50 (out of 113)

> upstate and 25 (out of 45) New York City birthing hospitals.

>

> Hospitals may participate in the program by submitting a brief

> application, along with their birth dose policy, to NYSDOH for

> review. The policy must clearly show that all newborns will be

> routinely vaccinated against hepatitis B at birth regardless of

> maternal hepatitis B surface antigen status, infant's insurance

> status, or individual physician preference.

>

> The provision of hepatitis B vaccine to all infants at birth

> provides a safety net to high-risk infants who do not receive

> appropriate prophylactic treatment against HBV transmission at

> birth, and to infants who are exposed to HBV postnatally from

> another family member or caregiver.

>

> In a 2002 survey of New York State birthing hospitals, cost of

> vaccine was identified as a barrier to vaccinating infants at

> birth by many hospitals. Through this new program, NYSDOH hopes

> to eliminate additional hospital costs for vaccine purchase

> while improving hospital compliance with recommended standards

> of care.

>

> Questions regarding the program can be directed to Perinatal

> Hepatitis B Program Manager Herlihy, RN, MS, at

> (518) 473-4437 or EJH04@...

> ----------------------------------------------------------------

>

> (5 of 9)

> November 18, 2004

> REPORT ON ILLINOIS HOSPITAL PRACTICES RELATED TO HEPATITIS B

> BIRTH DOSE AVAILABLE ONLINE

>

> The Illinois Chapter of the American Academy of Pediatrics (AAP)

> and the Illinois Department of Public Health collaborated on a

> study titled: " Report of Illinois Birthing Hospital Practices

> with Respect to the Administration of the Hepatitis B Birth Dose

> Vaccine and Hospital Participation in the Vaccines for Children-

> Plus Program. "

>

> The first four study objectives were

>

> (1) Assess Illinois birthing hospital practices and policies

> with respect to administration of the hepatitis B vaccine

> to newborns prior to hospital discharge.

> (2) Identify strategies to increase the hepatitis B birth

> dose vaccination rate in Illinois.

> (3) Determine how many Illinois birthing hospitals are

> currently enrolled in the Vaccines for Children-Plus

> (VFC-Plus) program. [VFC-Plus provides hospitals with

> vaccines, such as that for hepatitis B, for children who

> do not have insurance or for whom private insurance will

> not pay.]

> (4) Identify factors impacting enrollment/non-enrollment into

> the VFC-Plus program.

>

> The study found that the establishment of hospital policies, and

> more importantly, written standing orders for administration of

> the hepatitis B birth dose correlated with significantly higher

> hepatitis B birth dose administration rates. Hospitals enrolled

> in the Illinois VFC-Plus program demonstrated significantly

> higher hepatitis B birth dose vaccination rates when compared

> with non-enrolled hospitals.

>

> The study is an excellent example of collaboration between a

> state public health department and the state AAP chapter and can

> be used to stimulate discussion and planning in other states.

>

> To read the report online, go to:

> http://www.illinoisaap.org/HepBFinalReport.pdf

> ----------------------------------------------------------------

>

> (6 of 9)

> November 18, 2004

> CDC ISSUES NOTICE ABOUT FALSE-POSITIVE HBsAg TESTS

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/1/04.]

>

> CDC recently posted the following notice on the Viral Hepatitis

> section of the National Center for Infectious Diseases' (NCID)

> website.

>

> *********************

>

> FALSE-POSITIVE HBsAg TESTS NOTED

>

> BD and Abbott Diagnostics have initiated an investigation

> concerning the increased rate of initial and/or repeat reactive

> results for the AUSZYME Monoclonal test when using BD Vacutainer

> SST Plus tubes. As described in the AUSZYME package insert,

> reactive specimens should be repeated in duplicate. If either of

> the repeats is positive, the sample should then be tested with a

> licensed neutralizing confirmatory test, such as the HBsAg

> Confirmatory Assay. Only those specimens in which the HBsAg can

> be neutralized by the confirmatory test procedure may be

> designated as positive for HBsAg. All highly sensitive

> immunoassay systems have a potential for nonspecific reactions.

> The specificity of a repeatedly reactive specimen can be

> confirmed by neutralization tests.

>

> *********************

>

> To access the notice, go to:

> http://www.cdc.gov/ncidod/diseases/hepatitis/new.htm#top Click

> on the link titled " False positive HBsAg tests noted. "

>

> For additional technical or product-related information, read

> the BD technical bulletin at

>

http://www.bd.com/vacutainer/pdfs/techbulletins/Abbott_Diagnostics_17september20\

04.pdf

>

> If you have identified a cluster of infants born to false-

> positive HBsAg mothers, who because of the false-positive

> results, have been monitored as if they were born to HBsAg-

> positive mothers, please call A. Wang, MD, MPH, at NCID

> at (404) 371-5953.

> ----------------------------------------------------------------

>

> (7 of 9)

> November 18, 2004

> UPDATED: IAC REVISES TWO HEPATITIS-RELATED EDUCATION PIECES

>

> IAC recently revised two of its long-standing hepatitis B

> education pieces.

>

> " Hepatitis B Shots Are Recommended for All New Babies " is a

> brochure targeted at expectant or new parents who might question

> the need for, or timing of, infant vaccination against HBV.

>

> To access a ready-to-copy (PDF) version of " Hepatitis B Shots

> Are Recommended for All New Babies, " go to:

> http://www.immunize.org/catg.d/p4110bab.pdf

>

> To access a web-text (HTML) version of it, go to:

> http://www.immunize.org/catg.d/p4110bab.htm

>

> " Hepatitis B Information for Asian and Pacific Islander

> Americans " was created to answer the questions of Asian and

> Pacific Islander Americans (APIA), including immigrants and

> refugees, as well as persons of APIA descent born in the United

> States. The revised version includes an updated list of related

> organizations that readers might wish to contact.

>

> To access a ready-to-copy (PDF) version of " Hepatitis B

> Information for Asian and Pacific Islander Americans, " go to:

> http://www.immunize.org/catg.d/4190apia.pdf

>

> To access a web-text (HTML) version of it, go to:

> http://www.immunize.org/catg.d/4190apia.htm

> ----------------------------------------------------------------

>

> (8 of 9)

> November 18, 2004

> OCTOBER ISSUE OF " VACCINATE ADULTS " IS ON THE WEB

>

> IAC recently mailed the latest issue of " VACCINATE ADULTS "

> (October 2004) to 100,000 health professionals and others who

> work in the field of immunization. Packed with immunization

> resources for health professionals and patients, the 12-page

> issue is well worth downloading. All articles and education

> pieces, except editorials, have been thoroughly reviewed by

> immunization and hepatitis experts at CDC.

>

> PLEASE NOTE: Current as of September 2004, the resources in the

> October " VACCINATE ADULTS " do not contain the most recent

> information on influenza vaccine and vaccine supply. On October

> 5, ACIP developed interim influenza vaccine recommendations in

> response to Chiron Corporation's announcement that its trivalent

> inactivated influenza vaccine will not be available in the

> United States for the 2004-05 influenza season. The information

> in the interim recommendations is not reflected in any of the

> influenza information published in the October " VACCINATE

> ADULTS. "

>

> HOW TO READ " VACCINATE ADULTS " ON THE WEB

> You can view selected articles from the table of contents below

> or download the entire issue from the Web.

>

> To view the table of contents with links to individual articles,

> go to:

> http://www.immunize.org/va

>

> The PDF file of the entire issue, linked below, is large at

> 608,197 bytes. Some printers cannot print such a large file. For

> tips on downloading and printing PDF files, go to:

> http://www.immunize.org/nslt.d/tips.htm

>

> To download a ready-to-copy (PDF) version of the October issue,

> go to: http://www.immunize.org/va/va14.pdf

> ----------------------------------------------------------------

>

> (9 of 9)

> November 18, 2004

> NEW ISSUE OF " VIRAL HEPATITIS " AVAILABLE ON VHPB WEBSITE

>

> The Viral Hepatitis Prevention Board (VHPB) website has been

> updated to include a new issue of the publication " Viral

> Hepatitis. "

>

> " Viral Hepatitis, " Volume 13, Number 1, is prepared from

> material presented at the VHPB meeting on March 11-12, 2004, in

> Sevilla, Spain. The topic of this meeting was " Hepatitis B

> vaccine: long-term efficacy, booster policy, and impact of HBV

> mutants on hepatitis B vaccination programmes. "

>

> To access the ready-to-copy (PDF) versions of this issue,

> go to: http://www.vhpb.org/Default.asp?navItem=newsletters

>

> To access the home page of the VHPB website, go to:

> http://www.vhpb.org

>

> ===================================================================

> We hope you will forward this e-newsletter to others.

>

> Managing editor: A. , DDS, MPH

> Copy editor: Dale

> Editorial assistant: Janelle Tangonan

> ISSN: 1547-6375

>

> To subscribe or change your HEP EXPRESS email address, or to view

> past issues, please visit http://www.hepprograms.org/hepexpress

>

> This publication is supported by Grant No. U50/CCU523259 from

> the Division of Viral Hepatitis at the Centers for Disease Control

> and Prevention. Its contents are solely the responsibility of IAC

> and do not necessarily represent the official views of CDC.

> Circulation: 1,951

>

>

Link to comment
Share on other sites

>

> HEP EXPRESS

> Viral hepatitis news from the Immunization Action Coalition

>

> Combined Federal Campaign #0233

> Federal employees, including military, may contribute

> to IAC by using code #0233 on their pledge cards.

> ===========================================================

> Issue Number 23 November 18, 2004

>

> CONTENTS OF THIS ISSUE

>

> 1. CDC reports 89% decrease in acute hepatitis B infection

> among U.S. children and adolescents during 1990-2002

> 2. VIS translations: New hepatitis A vaccine VIS now

> available in eight additional languages

> 3. CDC creates viral hepatitis slide show for high school

> students

> 4. New York initiative provides free hepatitis B vaccine to

> hospitals adopting a universal birth dose policy

> 5. Report on Illinois hospital practices related to

> hepatitis B birth dose available online

> 6. CDC issues notice about false-positive HBsAg tests

> 7. Updated: IAC revises two hepatitis-related education

> pieces

> 8. October issue of " Vaccinate Adults " is on the Web

> 9. New issue of " Viral Hepatitis " available on VHPB website

> ----------------------------------------------------------------

>

> ABBREVIATIONS: ACIP, Advisory Committee on Immunization

> Practices; CDC, Centers for Disease Control and Prevention; DVH,

> Division of Viral Hepatitis; HAV, hepatitis A virus; HBV,

> hepatitis B virus; HCV, hepatitis C virus; IAC, Immunization

> Action Coalition; IDU, injection drug user; MMWR, Morbidity and

> Mortality Weekly Report; MSM, men who have sex with men; STD,

> sexually transmitted disease; VIS, Vaccine Information

> Statement; WHO, World Health Organization.

> ----------------------------------------------------------------

>

> (1 of 9)

> November 18, 2004

> CDC REPORTS 89% DECREASE IN ACUTE HEPATITIS B INFECTION AMONG

> U.S. CHILDREN AND ADOLESCENTS DURING 1990-2002

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/8/04.]

>

> CDC published " Acute Hepatitis B Among Children and Adolescents

> --United States, 1990-2002 " in the November 5 issue of MMWR. The

> article is reprinted below in its entirety, excluding

> references, two figures, and a table.

>

> ***********************

>

> Since the 1991 adoption of a comprehensive strategy to eliminate

> hepatitis B virus (HBV) transmission in the United States, the

> incidence of acute hepatitis B cases has declined steadily.

> Declines have been greatest among children born after the 1991

> recommendations for universal infant hepatitis B vaccination

> were implemented. In 1995, the elimination strategy was expanded

> to include routine vaccination of all adolescents aged 11-12

> years and, in 1999, to include children aged <18 years who had

> not been vaccinated previously. To describe the epidemiology of

> acute hepatitis B in children and adolescents in the United

> States, CDC analyzed notifiable disease surveillance data

> collected during 1990-2002 and data collected during 2001-2002

> through enhanced surveillance of reported cases of acute

> hepatitis B in children born after 1990. This report summarizes

> the results of that analysis, which indicated that the rate of

> acute hepatitis B in children and adolescents decreased 89%

> during 1990-2002 and that racial disparities in hepatitis B

> incidence have narrowed. Many confirmed cases in persons born

> after 1990 occurred among international adoptees and other

> children born outside the United States. Continued

> implementation of the hepatitis B elimination strategy and

> accurate surveillance data to monitor the impact of vaccination

> are necessary to sustain the decline of acute hepatitis B among

> children.

>

> Cases of acute hepatitis B were reported weekly to CDC by all 50

> states and the District of Columbia. Acute hepatitis B rates

> were calculated per 100,000 population by using population

> denominators from the U.S. Census Bureau. Acute hepatitis B was

> defined as an acute illness with (1) discrete onset of symptoms

> and jaundice or elevated serum aminotransferase levels and (2)

> laboratory evidence of either IgM antibody to hepatitis B core

> antigen (IgM anti-HBc) or hepatitis B surface antigen (HBsAg).

> Since March 2001, CDC has conducted enhanced hepatitis B

> surveillance, contacting states to confirm all reported cases of

> acute hepatitis B in persons born after 1990. State surveillance

> staff members were asked to verify each of the items in the case

> definition and provide information regarding vaccination history

> and country of birth. If errors were identified during this

> process, states were asked to correct the information in an

> updated submission to CDC.

>

> National Surveillance

> During 1990-2002, a total of 13,829 cases of acute hepatitis B

> were reported in the United States among persons aged <=19

> years. The incidence of reported cases declined steadily during

> this period, from 3.03 per 100,000 population in 1990 to 0.34 in

> 2002, representing a decline of 89%. The incidence among

> adolescents aged 15-19 years was consistently higher than the

> incidence among younger age groups, ranging from 8.69 per

> 100,000 population in 1990 to 1.13 in 2002. Children and

> adolescents in all age groups experienced steep declines in

> incidence during 1990-2002; incidence declined 94% among

> children aged 0-4 years, 92% among children aged 5-9 years,

> 93% among those aged 10-14 years, and 87% among adolescents aged

> 15-19 years.

>

> Among children and adolescents aged <=19 years in 1990,

> incidence per 100,000 population was highest among Asian/Pacific

> Islanders (A/PIs) (6.74) and blacks (4.29); whites had the

> lowest race-specific incidence (1.39). Differences in incidence

> between whites and A/PIs and between whites and blacks were 5.34

> and 2.90, respectively. From 1990 to 2002, rates declined 92%

> among A/PIs, 88% among whites, 88% among blacks, and 84% among

> American Indians/Alaskan Natives (AI/ANs). In 2002, the highest

> incidence per 100,000 population was among A/PIs (0.55),

> followed by blacks (0.51), AI/ANs (0.43), and whites (0.16);

> since 1990, differences in incidence between whites and A/PIs

> and whites and blacks declined by 93% and 88%, respectively.

>

> Case Investigations

> Follow-up investigations conducted by CDC and state and local

> health departments verified 19 case reports from 2001 and 2002

> as cases of acute hepatitis B among children born after 1990. Of

> the verified case reports, 12 (60%) involved males, eight (42%)

> involved children aged <2 years, and 11 (58%) involved children

> born in the United States. Seven (37%) reported race as A/PI,

> five (26%) as white, four (21%) as black, and three (16%) as

> unknown. Eight (42%) cases were reported in children born

> outside the United States, including six international adoptees

> (32%). Receipt of >=1 dose of hepatitis B vaccine was confirmed

> in three (16%) cases. Vaccination status was unknown for 12

> cases (63%).

>

> Editorial Note:

> The incidence of acute hepatitis B cases in U.S. children and

> adolescents decreased during the era of universal childhood

> vaccination. This decline coincided with an increase in

> hepatitis B vaccination coverage among children aged 19-35

> months, from 16% in 1992 to 90% in 2002, and among adolescents

> aged 13-15, from nearly 0 in 1992 to 67% in 2002.

>

> Declines in incidence were observed for children of all races,

> including A/PIs, whose rates historically have been higher than

> the national average. Because of the disproportionate burden of

> hepatitis B in A/PI communities, A/PI children were among the

> first groups for whom hepatitis B vaccination was recommended.

> The reduction of the disparity between A/PIs and other children

> is consistent with recent observations noting a decline in

> seroprevalence of HBV infection and successful implementation of

> routine hepatitis B vaccination among Asians who have recently

> immigrated to the United States. However, of the 11 verified

> cases during 2001-02 of acute hepatitis B among children born in

> the United States, three (27%) involved A/PIs. Although the

> national origins of these children's household members are

> unknown, the substantial proportion of A/PIs suggests that

> horizontal transmission of HBV among first-generation Asians

> might be a persistent problem.

>

> The higher incidence among older adolescents (aged 15-19 years)

> likely is attributable to their having been born before

> universal infant hepatitis B vaccination was recommended in

> 1991. Incidence among older adolescents is expected to decline

> further as the vaccinated cohort ages and as 1999

> recommendations to vaccinate all previously unvaccinated persons

> aged 0-18 years are fully implemented. The expected decline in

> rates among adolescents also might be augmented by laws in 32

> states requiring proof of hepatitis B vaccination before entry

> into middle school.

>

> Follow-up information obtained through surveillance of reported

> cases suggests that children born outside the United States,

> especially international adoptees, represent a substantial

> proportion of cases. Cases of acute hepatitis B among

> international adoptees might result from undervaccination and

> increased risk for exposure while living in areas with high

> prevalence of chronic HBV infection. International adoptees are

> exempt from U.S. regulations that bar entry to immigrants

> without documentation of hepatitis B vaccination. Studies have

> demonstrated that international adoptees exhibit low rates of

> protective titers of antibodies to vaccine-preventable diseases

> upon arrival in the United States, including adoptees with

> written evidence of age-appropriate vaccination provided by the

> birth country. Appropriate evaluation and remediation of the

> immunization status of international adoptees has been promoted

> through national guidelines; however, the extent to which these

> guidelines have been implemented is unknown.

>

> Despite the decline in acute hepatitis B cases among children in

> the United States, the presence of confirmed cases highlights

> the importance of infant vaccination and timely completion of

> the 3-dose vaccination series. The vaccination series should be

> started at birth, preferably before the newborn is discharged

> from the hospital. Infants born to women who are HBsAg positive

> or who have not had prenatal HBsAg testing should receive the

> first dose of hepatitis B vaccine within 12 hours of birth.

> Beginning the vaccination series at birth decreases the risk for

> perinatal HBV transmission and predicts successful completion of

> the series.

>

> Although enhanced surveillance data from verified case reports

> suggest that international adoptees and other children born

> outside the United States might particularly benefit from future

> prevention efforts, many case reports lacked risk factor

> information. As the incidence of acute hepatitis B among

> children and adolescents declines, accurate surveillance data

> become increasingly important to monitor the effect of

> immunization recommendations. Continued efforts of local, state,

> and national surveillance staff to improve data quality are

> critical to eliminating HBV transmission in the United States.

>

> ***********************

>

> To access a web-text (HTML) version of the complete article,

> go to: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5343a4.htm

>

> To access a ready-to-copy (PDF) version of this issue of MMWR,

> go to: http://www.cdc.gov/mmwr/PDF/wk/mm5343.pdf

>

> To receive a FREE electronic subscription to MMWR, go to:

> http://www.cdc.gov/mmwr/mmwrsubscribe.html

> ----------------------------------------------------------------

>

> (2 of 9)

> November 18, 2004

> VIS TRANSLATIONS: NEW HEPATITIS A VACCINE VIS NOW AVAILABLE IN

> EIGHT ADDITIONAL LANGUAGES

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/1/04.]

>

> Dated 8/4/04, the current version of the VIS for hepatitis A

> vaccine is now available on the IAC website in eight additional

> languages: Arabic, Armenian, Cambodian, Farsi, Haitian Creole,

> Hmong, Korean, and Vietnamese. IAC gratefully acknowledges the

> Massachusetts Department of Public Health for the Haitian Creole

> translation and the California Department of Health Services for

> the remaining translations.

>

> PLEASE NOTE: When hepatitis A vaccine is added to the Vaccine

> Injury Compensation Program's injury table, presumably later in

> 2004, another hepatitis A vaccine VIS will be issued. To avoid

> large printing expenses, print off only as many of the 8/4/04

> VISs as you anticipate needing for the next several months.

>

> To obtain a ready-to-copy (PDF) version of the VIS for hepatitis

> A vaccine in ARABIC, go to:

> http://www.immunize.org/vis/ab_hpa04.pdf

>

> To obtain it in ARMENIAN, go to:

> http://www.immunize.org/vis/ar_hpa04.pdf

>

> To obtain it in CAMBODIAN, go to:

> http://www.immunize.org/vis/ca_hpa04.pdf

>

> To obtain it in FARSI, go to:

> http://www.immunize.org/vis/fa_hpa04.pdf

>

> To obtain it in HAITIAN CREOLE, go to:

> http://www.immunize.org/vis/ha_hpa04.pdf

>

> To obtain it in HMONG, go to:

> http://www.immunize.org/vis/hm_hpa04.pdf

>

> To obtain it in KOREAN, go to:

> http://www.immunize.org/vis/ko_hpa04.pdf

>

> To obtain it in VIETNAMESE, go to:

> http://www.immunize.org/vis/vn_hpa04.pdf

>

> To obtain it in ENGLISH, go to:

> http://www.immunize.org/vis/v-hepa.pdf

>

> For information about the use of VISs, and for VISs in a total

> of 32 languages, visit IAC's VIS web section at

> http://www.immunize.org/vis

> ----------------------------------------------------------------

>

> (3 of 9)

> November 18, 2004

> CDC CREATES VIRAL HEPATITIS SLIDE SHOW FOR HIGH SCHOOL STUDENTS

>

> CDC's Division of Viral Hepatitis has developed a three-part

> slide set for high school students, designed to give adolescents

> basic information and raise awareness about HAV, HBV, and HCV.

> The set can be used as a resource for science or health

> projects, as an outline for a teaching tool, or as reference

> material to inform others (e.g., family, friends).

>

> To view or download this resource, go to:

> http://www.cdc.gov/ncidod/diseases/hepatitis/resource/training/hs_slideset.htm

> ----------------------------------------------------------------

>

> (4 of 9)

> November 18, 2004

> NEW YORK INITIATIVE PROVIDES FREE HEPATITIS B VACCINE TO

> HOSPITALS ADOPTING A UNIVERSAL BIRTH DOSE POLICY

>

> The Hepatitis B Birth Dose Program is an initiative of the New

> York State Department of Health (NYSDOH) that provides free

> hepatitis B vaccine to any birthing hospital in New York State

> that agrees to adopt a universal hepatitis B birth dose policy.

> Since October 2003, the program has enrolled 50 (out of 113)

> upstate and 25 (out of 45) New York City birthing hospitals.

>

> Hospitals may participate in the program by submitting a brief

> application, along with their birth dose policy, to NYSDOH for

> review. The policy must clearly show that all newborns will be

> routinely vaccinated against hepatitis B at birth regardless of

> maternal hepatitis B surface antigen status, infant's insurance

> status, or individual physician preference.

>

> The provision of hepatitis B vaccine to all infants at birth

> provides a safety net to high-risk infants who do not receive

> appropriate prophylactic treatment against HBV transmission at

> birth, and to infants who are exposed to HBV postnatally from

> another family member or caregiver.

>

> In a 2002 survey of New York State birthing hospitals, cost of

> vaccine was identified as a barrier to vaccinating infants at

> birth by many hospitals. Through this new program, NYSDOH hopes

> to eliminate additional hospital costs for vaccine purchase

> while improving hospital compliance with recommended standards

> of care.

>

> Questions regarding the program can be directed to Perinatal

> Hepatitis B Program Manager Herlihy, RN, MS, at

> (518) 473-4437 or EJH04@...

> ----------------------------------------------------------------

>

> (5 of 9)

> November 18, 2004

> REPORT ON ILLINOIS HOSPITAL PRACTICES RELATED TO HEPATITIS B

> BIRTH DOSE AVAILABLE ONLINE

>

> The Illinois Chapter of the American Academy of Pediatrics (AAP)

> and the Illinois Department of Public Health collaborated on a

> study titled: " Report of Illinois Birthing Hospital Practices

> with Respect to the Administration of the Hepatitis B Birth Dose

> Vaccine and Hospital Participation in the Vaccines for Children-

> Plus Program. "

>

> The first four study objectives were

>

> (1) Assess Illinois birthing hospital practices and policies

> with respect to administration of the hepatitis B vaccine

> to newborns prior to hospital discharge.

> (2) Identify strategies to increase the hepatitis B birth

> dose vaccination rate in Illinois.

> (3) Determine how many Illinois birthing hospitals are

> currently enrolled in the Vaccines for Children-Plus

> (VFC-Plus) program. [VFC-Plus provides hospitals with

> vaccines, such as that for hepatitis B, for children who

> do not have insurance or for whom private insurance will

> not pay.]

> (4) Identify factors impacting enrollment/non-enrollment into

> the VFC-Plus program.

>

> The study found that the establishment of hospital policies, and

> more importantly, written standing orders for administration of

> the hepatitis B birth dose correlated with significantly higher

> hepatitis B birth dose administration rates. Hospitals enrolled

> in the Illinois VFC-Plus program demonstrated significantly

> higher hepatitis B birth dose vaccination rates when compared

> with non-enrolled hospitals.

>

> The study is an excellent example of collaboration between a

> state public health department and the state AAP chapter and can

> be used to stimulate discussion and planning in other states.

>

> To read the report online, go to:

> http://www.illinoisaap.org/HepBFinalReport.pdf

> ----------------------------------------------------------------

>

> (6 of 9)

> November 18, 2004

> CDC ISSUES NOTICE ABOUT FALSE-POSITIVE HBsAg TESTS

>

> [The following is cross posted from the Immunization Action

> Coalition's " IAC EXPRESS " electronic newsletter, 11/1/04.]

>

> CDC recently posted the following notice on the Viral Hepatitis

> section of the National Center for Infectious Diseases' (NCID)

> website.

>

> *********************

>

> FALSE-POSITIVE HBsAg TESTS NOTED

>

> BD and Abbott Diagnostics have initiated an investigation

> concerning the increased rate of initial and/or repeat reactive

> results for the AUSZYME Monoclonal test when using BD Vacutainer

> SST Plus tubes. As described in the AUSZYME package insert,

> reactive specimens should be repeated in duplicate. If either of

> the repeats is positive, the sample should then be tested with a

> licensed neutralizing confirmatory test, such as the HBsAg

> Confirmatory Assay. Only those specimens in which the HBsAg can

> be neutralized by the confirmatory test procedure may be

> designated as positive for HBsAg. All highly sensitive

> immunoassay systems have a potential for nonspecific reactions.

> The specificity of a repeatedly reactive specimen can be

> confirmed by neutralization tests.

>

> *********************

>

> To access the notice, go to:

> http://www.cdc.gov/ncidod/diseases/hepatitis/new.htm#top Click

> on the link titled " False positive HBsAg tests noted. "

>

> For additional technical or product-related information, read

> the BD technical bulletin at

>

http://www.bd.com/vacutainer/pdfs/techbulletins/Abbott_Diagnostics_17september20\

04.pdf

>

> If you have identified a cluster of infants born to false-

> positive HBsAg mothers, who because of the false-positive

> results, have been monitored as if they were born to HBsAg-

> positive mothers, please call A. Wang, MD, MPH, at NCID

> at (404) 371-5953.

> ----------------------------------------------------------------

>

> (7 of 9)

> November 18, 2004

> UPDATED: IAC REVISES TWO HEPATITIS-RELATED EDUCATION PIECES

>

> IAC recently revised two of its long-standing hepatitis B

> education pieces.

>

> " Hepatitis B Shots Are Recommended for All New Babies " is a

> brochure targeted at expectant or new parents who might question

> the need for, or timing of, infant vaccination against HBV.

>

> To access a ready-to-copy (PDF) version of " Hepatitis B Shots

> Are Recommended for All New Babies, " go to:

> http://www.immunize.org/catg.d/p4110bab.pdf

>

> To access a web-text (HTML) version of it, go to:

> http://www.immunize.org/catg.d/p4110bab.htm

>

> " Hepatitis B Information for Asian and Pacific Islander

> Americans " was created to answer the questions of Asian and

> Pacific Islander Americans (APIA), including immigrants and

> refugees, as well as persons of APIA descent born in the United

> States. The revised version includes an updated list of related

> organizations that readers might wish to contact.

>

> To access a ready-to-copy (PDF) version of " Hepatitis B

> Information for Asian and Pacific Islander Americans, " go to:

> http://www.immunize.org/catg.d/4190apia.pdf

>

> To access a web-text (HTML) version of it, go to:

> http://www.immunize.org/catg.d/4190apia.htm

> ----------------------------------------------------------------

>

> (8 of 9)

> November 18, 2004

> OCTOBER ISSUE OF " VACCINATE ADULTS " IS ON THE WEB

>

> IAC recently mailed the latest issue of " VACCINATE ADULTS "

> (October 2004) to 100,000 health professionals and others who

> work in the field of immunization. Packed with immunization

> resources for health professionals and patients, the 12-page

> issue is well worth downloading. All articles and education

> pieces, except editorials, have been thoroughly reviewed by

> immunization and hepatitis experts at CDC.

>

> PLEASE NOTE: Current as of September 2004, the resources in the

> October " VACCINATE ADULTS " do not contain the most recent

> information on influenza vaccine and vaccine supply. On October

> 5, ACIP developed interim influenza vaccine recommendations in

> response to Chiron Corporation's announcement that its trivalent

> inactivated influenza vaccine will not be available in the

> United States for the 2004-05 influenza season. The information

> in the interim recommendations is not reflected in any of the

> influenza information published in the October " VACCINATE

> ADULTS. "

>

> HOW TO READ " VACCINATE ADULTS " ON THE WEB

> You can view selected articles from the table of contents below

> or download the entire issue from the Web.

>

> To view the table of contents with links to individual articles,

> go to:

> http://www.immunize.org/va

>

> The PDF file of the entire issue, linked below, is large at

> 608,197 bytes. Some printers cannot print such a large file. For

> tips on downloading and printing PDF files, go to:

> http://www.immunize.org/nslt.d/tips.htm

>

> To download a ready-to-copy (PDF) version of the October issue,

> go to: http://www.immunize.org/va/va14.pdf

> ----------------------------------------------------------------

>

> (9 of 9)

> November 18, 2004

> NEW ISSUE OF " VIRAL HEPATITIS " AVAILABLE ON VHPB WEBSITE

>

> The Viral Hepatitis Prevention Board (VHPB) website has been

> updated to include a new issue of the publication " Viral

> Hepatitis. "

>

> " Viral Hepatitis, " Volume 13, Number 1, is prepared from

> material presented at the VHPB meeting on March 11-12, 2004, in

> Sevilla, Spain. The topic of this meeting was " Hepatitis B

> vaccine: long-term efficacy, booster policy, and impact of HBV

> mutants on hepatitis B vaccination programmes. "

>

> To access the ready-to-copy (PDF) versions of this issue,

> go to: http://www.vhpb.org/Default.asp?navItem=newsletters

>

> To access the home page of the VHPB website, go to:

> http://www.vhpb.org

>

> ===================================================================

> We hope you will forward this e-newsletter to others.

>

> Managing editor: A. , DDS, MPH

> Copy editor: Dale

> Editorial assistant: Janelle Tangonan

> ISSN: 1547-6375

>

> To subscribe or change your HEP EXPRESS email address, or to view

> past issues, please visit http://www.hepprograms.org/hepexpress

>

> This publication is supported by Grant No. U50/CCU523259 from

> the Division of Viral Hepatitis at the Centers for Disease Control

> and Prevention. Its contents are solely the responsibility of IAC

> and do not necessarily represent the official views of CDC.

> Circulation: 1,951

>

>

Link to comment
Share on other sites

Join the conversation

You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...