Terbinafine-induced hepatic failure requiring liver transplantation

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Liver Transpl. 2007 Jan;13(1):162-4.

Terbinafine-induced hepatic failure requiring liver transplantation.

Perveze Z, MW, Rubin RA, Sellers M, Zayas C, JL, Cross R,

K, B, Shrestha R.

Piedmont Transplant Services, Piedmont Hospital, Atlanta, GA.

Drug-induced liver disease accounts for about 50% of acute or subacute liver

failure in the United States. United Network of Organ Sharing (UNOS) data

suggest 8%-20% of liver transplantation in this country per year is for

fulminant liver failure due to drugs. Even though the most common medication

implicated in acute liver injury is acetaminophen (75%), there are numerous

other drugs that are responsible for acute and chronic liver injury. A

variety of antifungal medications are known to cause a wide range of liver

injury from a mild hepatocellular-cholestatic injury pattern to

acute/subacute liver failure. Terbinafine is one of the antifungals that

have been associated with such liver injuries. We report a case of

terbinafine-induced severe liver failure requiring liver transplantation.

Liver Transpl 13:162-164, 2007. © 2006 AASLD.

PMID: 17192859 [PubMed - in process]

_________________________________________________________________

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[Guest guest]

Liver Transpl. 2007 Jan;13(1):162-4.

Terbinafine-induced hepatic failure requiring liver transplantation.

Perveze Z, MW, Rubin RA, Sellers M, Zayas C, JL, Cross R,

K, B, Shrestha R.

Piedmont Transplant Services, Piedmont Hospital, Atlanta, GA.

Drug-induced liver disease accounts for about 50% of acute or subacute liver

failure in the United States. United Network of Organ Sharing (UNOS) data

suggest 8%-20% of liver transplantation in this country per year is for

fulminant liver failure due to drugs. Even though the most common medication

implicated in acute liver injury is acetaminophen (75%), there are numerous

other drugs that are responsible for acute and chronic liver injury. A

variety of antifungal medications are known to cause a wide range of liver

injury from a mild hepatocellular-cholestatic injury pattern to

acute/subacute liver failure. Terbinafine is one of the antifungals that

have been associated with such liver injuries. We report a case of

terbinafine-induced severe liver failure requiring liver transplantation.

Liver Transpl 13:162-164, 2007. © 2006 AASLD.

PMID: 17192859 [PubMed - in process]

_________________________________________________________________

Communicate instantly! Use your Hotmail address to sign into Windows Live

Messenger now. http://get.live.com/messenger/overview

[Guest guest]

Liver Transpl. 2007 Jan;13(1):162-4.

Terbinafine-induced hepatic failure requiring liver transplantation.

Perveze Z, MW, Rubin RA, Sellers M, Zayas C, JL, Cross R,

K, B, Shrestha R.

Piedmont Transplant Services, Piedmont Hospital, Atlanta, GA.

Drug-induced liver disease accounts for about 50% of acute or subacute liver

failure in the United States. United Network of Organ Sharing (UNOS) data

suggest 8%-20% of liver transplantation in this country per year is for

fulminant liver failure due to drugs. Even though the most common medication

implicated in acute liver injury is acetaminophen (75%), there are numerous

other drugs that are responsible for acute and chronic liver injury. A

variety of antifungal medications are known to cause a wide range of liver

injury from a mild hepatocellular-cholestatic injury pattern to

acute/subacute liver failure. Terbinafine is one of the antifungals that

have been associated with such liver injuries. We report a case of

terbinafine-induced severe liver failure requiring liver transplantation.

Liver Transpl 13:162-164, 2007. © 2006 AASLD.

PMID: 17192859 [PubMed - in process]

_________________________________________________________________

Communicate instantly! Use your Hotmail address to sign into Windows Live

Messenger now. http://get.live.com/messenger/overview

[Guest guest]

Liver Transpl. 2007 Jan;13(1):162-4.

Terbinafine-induced hepatic failure requiring liver transplantation.

Perveze Z, MW, Rubin RA, Sellers M, Zayas C, JL, Cross R,

K, B, Shrestha R.

Piedmont Transplant Services, Piedmont Hospital, Atlanta, GA.

Drug-induced liver disease accounts for about 50% of acute or subacute liver

failure in the United States. United Network of Organ Sharing (UNOS) data

suggest 8%-20% of liver transplantation in this country per year is for

fulminant liver failure due to drugs. Even though the most common medication

implicated in acute liver injury is acetaminophen (75%), there are numerous

other drugs that are responsible for acute and chronic liver injury. A

variety of antifungal medications are known to cause a wide range of liver

injury from a mild hepatocellular-cholestatic injury pattern to

acute/subacute liver failure. Terbinafine is one of the antifungals that

have been associated with such liver injuries. We report a case of

terbinafine-induced severe liver failure requiring liver transplantation.

Liver Transpl 13:162-164, 2007. © 2006 AASLD.

PMID: 17192859 [PubMed - in process]

_________________________________________________________________

Communicate instantly! Use your Hotmail address to sign into Windows Live

Messenger now. http://get.live.com/messenger/overview