Association between prenatal exposure to analgesics and risk of schizophrenia

[Guest guest]

I think this is saying aspirin & tylenol & ibuprofen while pregnant leads to a

big increase of schizophrenia in the children.

http://bjp.rcpsych.org/cgi/content/abstract/185/5/366

Association between prenatal exposure to analgesics and risk of schizophrenia

Holger J. Sørensen, MD, PhD

Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen

University Hospital, Denmark

L. Mortensen, CandPsych

Department of Health Psychology, Institute of Public Health, University of

Copenhagen, Denmark

June M. Reinisch, PhD

Kinsey Institute for Research in Sex, Gender and Reproduction, Indiana

University, Bloomington, Indiana

Sarnoff A. Mednick, PhD, DrMedSci

Social Science Research Institute, University of Southern California, Los

Angeles, California, USA

Correspondence: Lykke Mortensen, Department of Health Psychology,

Copenhagen University, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. Tel: +45

3532 7839; fax: +45 3532 7748; e-mail: e.l.mortensen@...

Declaration of interest None. Funding detailed in Acknowledgements.

Background Disturbances in the central nervous system originating during foetal

life may increase the risk of schizophrenia.

Aims To illuminate the hypothesis that prenatal exposure to analgesics may

affect foetal neurodevelopment, leading to increased risk of schizophrenia in

adulthood.

Method Using data from the Copenhagen Perinatal Cohort and from the Danish

Psychiatric Central Register, we studied the relationship between prenatal

exposure to analgesics and the risk of schizophrenia. The effect of prenatal

exposure was adjusted for parental history of schizophrenia, second-trimester

viral infections, concomitant drug treatment during pregnancy, an index of

pregnancy complications, parental social status and parental age.

Results In a risk set of 7999 individuals, 116 cases of schizophrenia were found

(1.5%). Prenatal exposure to analgesics in the second trimester was associated

with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9–12.0).Independent of

the covariates, the effect remained statistically significant.

Conclusions Independent of a wide range of possible confounders, a significant

association between second-trimester exposure to analgesics and increased risk

of schizophrenia was observed.

[Guest guest]

I think this is saying aspirin & tylenol & ibuprofen while pregnant leads to a

big increase of schizophrenia in the children.

http://bjp.rcpsych.org/cgi/content/abstract/185/5/366

Association between prenatal exposure to analgesics and risk of schizophrenia

Holger J. Sørensen, MD, PhD

Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen

University Hospital, Denmark

L. Mortensen, CandPsych

Department of Health Psychology, Institute of Public Health, University of

Copenhagen, Denmark

June M. Reinisch, PhD

Kinsey Institute for Research in Sex, Gender and Reproduction, Indiana

University, Bloomington, Indiana

Sarnoff A. Mednick, PhD, DrMedSci

Social Science Research Institute, University of Southern California, Los

Angeles, California, USA

Correspondence: Lykke Mortensen, Department of Health Psychology,

Copenhagen University, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. Tel: +45

3532 7839; fax: +45 3532 7748; e-mail: e.l.mortensen@...

Declaration of interest None. Funding detailed in Acknowledgements.

Background Disturbances in the central nervous system originating during foetal

life may increase the risk of schizophrenia.

Aims To illuminate the hypothesis that prenatal exposure to analgesics may

affect foetal neurodevelopment, leading to increased risk of schizophrenia in

adulthood.

Method Using data from the Copenhagen Perinatal Cohort and from the Danish

Psychiatric Central Register, we studied the relationship between prenatal

exposure to analgesics and the risk of schizophrenia. The effect of prenatal

exposure was adjusted for parental history of schizophrenia, second-trimester

viral infections, concomitant drug treatment during pregnancy, an index of

pregnancy complications, parental social status and parental age.

Results In a risk set of 7999 individuals, 116 cases of schizophrenia were found

(1.5%). Prenatal exposure to analgesics in the second trimester was associated

with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9–12.0).Independent of

the covariates, the effect remained statistically significant.

Conclusions Independent of a wide range of possible confounders, a significant

association between second-trimester exposure to analgesics and increased risk

of schizophrenia was observed.

[Guest guest]

I think this is saying aspirin & tylenol & ibuprofen while pregnant leads to a

big increase of schizophrenia in the children.

http://bjp.rcpsych.org/cgi/content/abstract/185/5/366

Association between prenatal exposure to analgesics and risk of schizophrenia

Holger J. Sørensen, MD, PhD

Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen

University Hospital, Denmark

L. Mortensen, CandPsych

Department of Health Psychology, Institute of Public Health, University of

Copenhagen, Denmark

June M. Reinisch, PhD

Kinsey Institute for Research in Sex, Gender and Reproduction, Indiana

University, Bloomington, Indiana

Sarnoff A. Mednick, PhD, DrMedSci

Social Science Research Institute, University of Southern California, Los

Angeles, California, USA

Correspondence: Lykke Mortensen, Department of Health Psychology,

Copenhagen University, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. Tel: +45

3532 7839; fax: +45 3532 7748; e-mail: e.l.mortensen@...

Declaration of interest None. Funding detailed in Acknowledgements.

Background Disturbances in the central nervous system originating during foetal

life may increase the risk of schizophrenia.

Aims To illuminate the hypothesis that prenatal exposure to analgesics may

affect foetal neurodevelopment, leading to increased risk of schizophrenia in

adulthood.

Method Using data from the Copenhagen Perinatal Cohort and from the Danish

Psychiatric Central Register, we studied the relationship between prenatal

exposure to analgesics and the risk of schizophrenia. The effect of prenatal

exposure was adjusted for parental history of schizophrenia, second-trimester

viral infections, concomitant drug treatment during pregnancy, an index of

pregnancy complications, parental social status and parental age.

Results In a risk set of 7999 individuals, 116 cases of schizophrenia were found

(1.5%). Prenatal exposure to analgesics in the second trimester was associated

with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9–12.0).Independent of

the covariates, the effect remained statistically significant.

Conclusions Independent of a wide range of possible confounders, a significant

association between second-trimester exposure to analgesics and increased risk

of schizophrenia was observed.

[Guest guest]

I think this is saying aspirin & tylenol & ibuprofen while pregnant leads to a

big increase of schizophrenia in the children.

http://bjp.rcpsych.org/cgi/content/abstract/185/5/366

Association between prenatal exposure to analgesics and risk of schizophrenia

Holger J. Sørensen, MD, PhD

Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen

University Hospital, Denmark

L. Mortensen, CandPsych

Department of Health Psychology, Institute of Public Health, University of

Copenhagen, Denmark

June M. Reinisch, PhD

Kinsey Institute for Research in Sex, Gender and Reproduction, Indiana

University, Bloomington, Indiana

Sarnoff A. Mednick, PhD, DrMedSci

Social Science Research Institute, University of Southern California, Los

Angeles, California, USA

Correspondence: Lykke Mortensen, Department of Health Psychology,

Copenhagen University, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. Tel: +45

3532 7839; fax: +45 3532 7748; e-mail: e.l.mortensen@...

Declaration of interest None. Funding detailed in Acknowledgements.

Background Disturbances in the central nervous system originating during foetal

life may increase the risk of schizophrenia.

Aims To illuminate the hypothesis that prenatal exposure to analgesics may

affect foetal neurodevelopment, leading to increased risk of schizophrenia in

adulthood.

Method Using data from the Copenhagen Perinatal Cohort and from the Danish

Psychiatric Central Register, we studied the relationship between prenatal

exposure to analgesics and the risk of schizophrenia. The effect of prenatal

exposure was adjusted for parental history of schizophrenia, second-trimester

viral infections, concomitant drug treatment during pregnancy, an index of

pregnancy complications, parental social status and parental age.

Results In a risk set of 7999 individuals, 116 cases of schizophrenia were found

(1.5%). Prenatal exposure to analgesics in the second trimester was associated

with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9–12.0).Independent of

the covariates, the effect remained statistically significant.

Conclusions Independent of a wide range of possible confounders, a significant

association between second-trimester exposure to analgesics and increased risk

of schizophrenia was observed.