Values of high-resolution computed tomography and pulmonary function tests in managements of patients with chronic hepatitis C virus infection

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World J Gastroenterol. 2004 Feb 1;10(3):381-4. Related Articles, Links

Values of high-resolution computed tomography and pulmonary function tests

in managements of patients with chronic hepatitis C virus infection.

Okutan O, Kartaloglu Z, Ilvan A, Kutlu A, Bozkanat E, Silit E.

GATA Haydarpasa Training Hospital, Department of Pulmonary Diseases,

Istanbul, Turkey. oguzhanokutan@...

AIM: To investigate pulmonary involvement via pulmonary function tests (PFT)

and high-resolution computed tomography (HRCT) in patients with chronic

hepatitis C virus (HCV) infection. METHODS: Thirty-four patients with

chronic HCV infection without diagnosis of any pulmonary diseases and 10

healthy cases were enrolled in the study. PFT and HRCT were performed in all

cases. RESULTS: A decrease lower than 80% of the predicted value was

detected in vital capacity in 9/34 patients, in forced expiratory volume in

one second in 8/34 patients, and in forced expiratory flow 25-75 in 15/34

patients, respectively. Carbon monoxide diffusing capacity (DLCO) was

decreased in 26/34 patients. Findings of interstitial pulmonary involvement

were detected in the HRCT of 16/34 patients. Significant difference was

found between controls and patients with HCV infection in findings of HRCT

(chi2=4.7, P=0.003). Knodell histological activity index (KHAI) of 28/34

patients in whom liver biopsy was applied was 9.0+/-4.7. HRCT findings, PFT

values and DLCO were not affected by KHAI in patients with HCV infection. In

these patients, all the parameters were related with age. CONCLUSION: We

suggest that chronic hepatitis C virus infection may cause pulmonary

interstitial involvement without evident respiratory symptoms.

PMID: 14760762 [PubMed - indexed for MEDLINE]

[Guest guest]

World J Gastroenterol. 2004 Feb 1;10(3):381-4. Related Articles, Links

Values of high-resolution computed tomography and pulmonary function tests

in managements of patients with chronic hepatitis C virus infection.

Okutan O, Kartaloglu Z, Ilvan A, Kutlu A, Bozkanat E, Silit E.

GATA Haydarpasa Training Hospital, Department of Pulmonary Diseases,

Istanbul, Turkey. oguzhanokutan@...

AIM: To investigate pulmonary involvement via pulmonary function tests (PFT)

and high-resolution computed tomography (HRCT) in patients with chronic

hepatitis C virus (HCV) infection. METHODS: Thirty-four patients with

chronic HCV infection without diagnosis of any pulmonary diseases and 10

healthy cases were enrolled in the study. PFT and HRCT were performed in all

cases. RESULTS: A decrease lower than 80% of the predicted value was

detected in vital capacity in 9/34 patients, in forced expiratory volume in

one second in 8/34 patients, and in forced expiratory flow 25-75 in 15/34

patients, respectively. Carbon monoxide diffusing capacity (DLCO) was

decreased in 26/34 patients. Findings of interstitial pulmonary involvement

were detected in the HRCT of 16/34 patients. Significant difference was

found between controls and patients with HCV infection in findings of HRCT

(chi2=4.7, P=0.003). Knodell histological activity index (KHAI) of 28/34

patients in whom liver biopsy was applied was 9.0+/-4.7. HRCT findings, PFT

values and DLCO were not affected by KHAI in patients with HCV infection. In

these patients, all the parameters were related with age. CONCLUSION: We

suggest that chronic hepatitis C virus infection may cause pulmonary

interstitial involvement without evident respiratory symptoms.

PMID: 14760762 [PubMed - indexed for MEDLINE]

[Guest guest]

World J Gastroenterol. 2004 Feb 1;10(3):381-4. Related Articles, Links

Values of high-resolution computed tomography and pulmonary function tests

in managements of patients with chronic hepatitis C virus infection.

Okutan O, Kartaloglu Z, Ilvan A, Kutlu A, Bozkanat E, Silit E.

GATA Haydarpasa Training Hospital, Department of Pulmonary Diseases,

Istanbul, Turkey. oguzhanokutan@...

AIM: To investigate pulmonary involvement via pulmonary function tests (PFT)

and high-resolution computed tomography (HRCT) in patients with chronic

hepatitis C virus (HCV) infection. METHODS: Thirty-four patients with

chronic HCV infection without diagnosis of any pulmonary diseases and 10

healthy cases were enrolled in the study. PFT and HRCT were performed in all

cases. RESULTS: A decrease lower than 80% of the predicted value was

detected in vital capacity in 9/34 patients, in forced expiratory volume in

one second in 8/34 patients, and in forced expiratory flow 25-75 in 15/34

patients, respectively. Carbon monoxide diffusing capacity (DLCO) was

decreased in 26/34 patients. Findings of interstitial pulmonary involvement

were detected in the HRCT of 16/34 patients. Significant difference was

found between controls and patients with HCV infection in findings of HRCT

(chi2=4.7, P=0.003). Knodell histological activity index (KHAI) of 28/34

patients in whom liver biopsy was applied was 9.0+/-4.7. HRCT findings, PFT

values and DLCO were not affected by KHAI in patients with HCV infection. In

these patients, all the parameters were related with age. CONCLUSION: We

suggest that chronic hepatitis C virus infection may cause pulmonary

interstitial involvement without evident respiratory symptoms.

PMID: 14760762 [PubMed - indexed for MEDLINE]

[Guest guest]

World J Gastroenterol. 2004 Feb 1;10(3):381-4. Related Articles, Links

Values of high-resolution computed tomography and pulmonary function tests

in managements of patients with chronic hepatitis C virus infection.

Okutan O, Kartaloglu Z, Ilvan A, Kutlu A, Bozkanat E, Silit E.

GATA Haydarpasa Training Hospital, Department of Pulmonary Diseases,

Istanbul, Turkey. oguzhanokutan@...

AIM: To investigate pulmonary involvement via pulmonary function tests (PFT)

and high-resolution computed tomography (HRCT) in patients with chronic

hepatitis C virus (HCV) infection. METHODS: Thirty-four patients with

chronic HCV infection without diagnosis of any pulmonary diseases and 10

healthy cases were enrolled in the study. PFT and HRCT were performed in all

cases. RESULTS: A decrease lower than 80% of the predicted value was

detected in vital capacity in 9/34 patients, in forced expiratory volume in

one second in 8/34 patients, and in forced expiratory flow 25-75 in 15/34

patients, respectively. Carbon monoxide diffusing capacity (DLCO) was

decreased in 26/34 patients. Findings of interstitial pulmonary involvement

were detected in the HRCT of 16/34 patients. Significant difference was

found between controls and patients with HCV infection in findings of HRCT

(chi2=4.7, P=0.003). Knodell histological activity index (KHAI) of 28/34

patients in whom liver biopsy was applied was 9.0+/-4.7. HRCT findings, PFT

values and DLCO were not affected by KHAI in patients with HCV infection. In

these patients, all the parameters were related with age. CONCLUSION: We

suggest that chronic hepatitis C virus infection may cause pulmonary

interstitial involvement without evident respiratory symptoms.

PMID: 14760762 [PubMed - indexed for MEDLINE]