HIV and hepatitis C virus RNA in seronegative organ and tissue donors

[Guest guest]

THE LANCET

Research Letters

HIV and hepatitis C virus RNA in seronegative organ and tissue donors

Dominique Challine, MDa, Bertrand Pellegrin, PharmDa, Magali Bouvier-Alias,

PharmDa, Pierrette Rigota, Liliane Laperchea and Prof Jean-Michel Pawlotsky,

MD, , a

a Viral Emergency and Organ, Tissue, and Cell Donor Screening Laboratory,

Department of Virology (INSERM U635), Hôpital Henri Mondor, Université Paris

XII, Créteil, France

Available online 29 October 2004.

Abstract

The objective of our study was to determine whether nucleic acid testing

could detect HIV RNA or hepatitis C virus (HCV) RNA in a large series of

seronegative organ and tissue donors, and whether this technique should be

routinely used to improve viral safety of grafts. We studied 2236 organ

donors, 636 tissue donors, and 177 cornea donors. We identified five HCV

RNA-positive donors in 2119 HCV-seronegative organ donors, and one HCV

RNA-positive donor in 631 HCV-seronegative tissue donors. No

HIV-seronegative, HIV RNA-positive donor was identified. Our data suggest

that routine nucleic acid testing of organ and tissue donors might increase

viral safety in transplantation.

Corresponding author. Correspondence to: Prof Jean-Michel Pawlotsky, Service

de Virologie, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de

Tassigny, 94010 Créteil, France

The Lancet

Volume 364, Issue 9445 , 30 October 2004, Pages 1611-1612

[Guest guest]

THE LANCET

Research Letters

HIV and hepatitis C virus RNA in seronegative organ and tissue donors

Dominique Challine, MDa, Bertrand Pellegrin, PharmDa, Magali Bouvier-Alias,

PharmDa, Pierrette Rigota, Liliane Laperchea and Prof Jean-Michel Pawlotsky,

MD, , a

a Viral Emergency and Organ, Tissue, and Cell Donor Screening Laboratory,

Department of Virology (INSERM U635), Hôpital Henri Mondor, Université Paris

XII, Créteil, France

Available online 29 October 2004.

Abstract

The objective of our study was to determine whether nucleic acid testing

could detect HIV RNA or hepatitis C virus (HCV) RNA in a large series of

seronegative organ and tissue donors, and whether this technique should be

routinely used to improve viral safety of grafts. We studied 2236 organ

donors, 636 tissue donors, and 177 cornea donors. We identified five HCV

RNA-positive donors in 2119 HCV-seronegative organ donors, and one HCV

RNA-positive donor in 631 HCV-seronegative tissue donors. No

HIV-seronegative, HIV RNA-positive donor was identified. Our data suggest

that routine nucleic acid testing of organ and tissue donors might increase

viral safety in transplantation.

Corresponding author. Correspondence to: Prof Jean-Michel Pawlotsky, Service

de Virologie, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de

Tassigny, 94010 Créteil, France

The Lancet

Volume 364, Issue 9445 , 30 October 2004, Pages 1611-1612

[Guest guest]

THE LANCET

Research Letters

HIV and hepatitis C virus RNA in seronegative organ and tissue donors

Dominique Challine, MDa, Bertrand Pellegrin, PharmDa, Magali Bouvier-Alias,

PharmDa, Pierrette Rigota, Liliane Laperchea and Prof Jean-Michel Pawlotsky,

MD, , a

a Viral Emergency and Organ, Tissue, and Cell Donor Screening Laboratory,

Department of Virology (INSERM U635), Hôpital Henri Mondor, Université Paris

XII, Créteil, France

Available online 29 October 2004.

Abstract

The objective of our study was to determine whether nucleic acid testing

could detect HIV RNA or hepatitis C virus (HCV) RNA in a large series of

seronegative organ and tissue donors, and whether this technique should be

routinely used to improve viral safety of grafts. We studied 2236 organ

donors, 636 tissue donors, and 177 cornea donors. We identified five HCV

RNA-positive donors in 2119 HCV-seronegative organ donors, and one HCV

RNA-positive donor in 631 HCV-seronegative tissue donors. No

HIV-seronegative, HIV RNA-positive donor was identified. Our data suggest

that routine nucleic acid testing of organ and tissue donors might increase

viral safety in transplantation.

Corresponding author. Correspondence to: Prof Jean-Michel Pawlotsky, Service

de Virologie, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de

Tassigny, 94010 Créteil, France

The Lancet

Volume 364, Issue 9445 , 30 October 2004, Pages 1611-1612

[Guest guest]

THE LANCET

Research Letters

HIV and hepatitis C virus RNA in seronegative organ and tissue donors

Dominique Challine, MDa, Bertrand Pellegrin, PharmDa, Magali Bouvier-Alias,

PharmDa, Pierrette Rigota, Liliane Laperchea and Prof Jean-Michel Pawlotsky,

MD, , a

a Viral Emergency and Organ, Tissue, and Cell Donor Screening Laboratory,

Department of Virology (INSERM U635), Hôpital Henri Mondor, Université Paris

XII, Créteil, France

Available online 29 October 2004.

Abstract

The objective of our study was to determine whether nucleic acid testing

could detect HIV RNA or hepatitis C virus (HCV) RNA in a large series of

seronegative organ and tissue donors, and whether this technique should be

routinely used to improve viral safety of grafts. We studied 2236 organ

donors, 636 tissue donors, and 177 cornea donors. We identified five HCV

RNA-positive donors in 2119 HCV-seronegative organ donors, and one HCV

RNA-positive donor in 631 HCV-seronegative tissue donors. No

HIV-seronegative, HIV RNA-positive donor was identified. Our data suggest

that routine nucleic acid testing of organ and tissue donors might increase

viral safety in transplantation.

Corresponding author. Correspondence to: Prof Jean-Michel Pawlotsky, Service

de Virologie, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de

Tassigny, 94010 Créteil, France

The Lancet

Volume 364, Issue 9445 , 30 October 2004, Pages 1611-1612