X gene mutations in hepatitis B patients with cirrhosis, with and without hepatocellular carcinoma

[Guest guest]

J Med Virol. 2009 Oct;81(10):1721-5.

X gene mutations in hepatitis B patients with cirrhosis, with and without

hepatocellular carcinoma.

Choi CS, Cho EY, Park R, Kim SJ, Cho JH, Kim HC.

Department of Internal Medicine, Wonkwang University College of Medicine, Iksan,

Korea.

Specific mutations in the hepatitis B virus (HBV) genome have been reported to

be associated with the development of hepatocellular carcinoma (HCC). The goal

of this study was to determine whether mutations in the HBV X gene are

associated with the development of HCC in hepatitis B patients with cirrhosis.

Forty-two patients infected with HBV genotype C2 with cirrhosis and HCC were

compared with 46 patients with cirrhosis but without HCC. X gene mutations were

determined by direct sequencing in all patients. The HCC and non-HCC groups were

similar with respect to clinical characteristics, and the presence of

T1762/A1764, T1653, and V1753 mutations was not significantly different between

the two groups (P = 0.068, P = 0.097, P = 0.442, respectively). Only the B1499

mutation was associated significantly with HCC (P = 0.015) (odds ratio: 3.42,

95% CI: 1.24-9.48). In hepatitis Be antigen (HBeAg)-positive patients, advanced

age was associated significantly with HCC (P = 0.038), whereas in HBeAg-negative

patients, the B1499 mutation was associated more significantly with HCC (P =

0.01). Patients in the B1499 mutation group exhibited significantly higher AST

and ALT levels compared with patients infected the wild-type virus. In

conclusion, B1499 is a novel mutation associated with HCC in Korean patients

with cirrhosis infected with HBV genotype C2.

PMID: 19697408 [PubMed - in process]

[Guest guest]

J Med Virol. 2009 Oct;81(10):1721-5.

X gene mutations in hepatitis B patients with cirrhosis, with and without

hepatocellular carcinoma.

Choi CS, Cho EY, Park R, Kim SJ, Cho JH, Kim HC.

Department of Internal Medicine, Wonkwang University College of Medicine, Iksan,

Korea.

Specific mutations in the hepatitis B virus (HBV) genome have been reported to

be associated with the development of hepatocellular carcinoma (HCC). The goal

of this study was to determine whether mutations in the HBV X gene are

associated with the development of HCC in hepatitis B patients with cirrhosis.

Forty-two patients infected with HBV genotype C2 with cirrhosis and HCC were

compared with 46 patients with cirrhosis but without HCC. X gene mutations were

determined by direct sequencing in all patients. The HCC and non-HCC groups were

similar with respect to clinical characteristics, and the presence of

T1762/A1764, T1653, and V1753 mutations was not significantly different between

the two groups (P = 0.068, P = 0.097, P = 0.442, respectively). Only the B1499

mutation was associated significantly with HCC (P = 0.015) (odds ratio: 3.42,

95% CI: 1.24-9.48). In hepatitis Be antigen (HBeAg)-positive patients, advanced

age was associated significantly with HCC (P = 0.038), whereas in HBeAg-negative

patients, the B1499 mutation was associated more significantly with HCC (P =

0.01). Patients in the B1499 mutation group exhibited significantly higher AST

and ALT levels compared with patients infected the wild-type virus. In

conclusion, B1499 is a novel mutation associated with HCC in Korean patients

with cirrhosis infected with HBV genotype C2.

PMID: 19697408 [PubMed - in process]

[Guest guest]

J Med Virol. 2009 Oct;81(10):1721-5.

X gene mutations in hepatitis B patients with cirrhosis, with and without

hepatocellular carcinoma.

Choi CS, Cho EY, Park R, Kim SJ, Cho JH, Kim HC.

Department of Internal Medicine, Wonkwang University College of Medicine, Iksan,

Korea.

Specific mutations in the hepatitis B virus (HBV) genome have been reported to

be associated with the development of hepatocellular carcinoma (HCC). The goal

of this study was to determine whether mutations in the HBV X gene are

associated with the development of HCC in hepatitis B patients with cirrhosis.

Forty-two patients infected with HBV genotype C2 with cirrhosis and HCC were

compared with 46 patients with cirrhosis but without HCC. X gene mutations were

determined by direct sequencing in all patients. The HCC and non-HCC groups were

similar with respect to clinical characteristics, and the presence of

T1762/A1764, T1653, and V1753 mutations was not significantly different between

the two groups (P = 0.068, P = 0.097, P = 0.442, respectively). Only the B1499

mutation was associated significantly with HCC (P = 0.015) (odds ratio: 3.42,

95% CI: 1.24-9.48). In hepatitis Be antigen (HBeAg)-positive patients, advanced

age was associated significantly with HCC (P = 0.038), whereas in HBeAg-negative

patients, the B1499 mutation was associated more significantly with HCC (P =

0.01). Patients in the B1499 mutation group exhibited significantly higher AST

and ALT levels compared with patients infected the wild-type virus. In

conclusion, B1499 is a novel mutation associated with HCC in Korean patients

with cirrhosis infected with HBV genotype C2.

PMID: 19697408 [PubMed - in process]

[Guest guest]

J Med Virol. 2009 Oct;81(10):1721-5.

X gene mutations in hepatitis B patients with cirrhosis, with and without

hepatocellular carcinoma.

Choi CS, Cho EY, Park R, Kim SJ, Cho JH, Kim HC.

Department of Internal Medicine, Wonkwang University College of Medicine, Iksan,

Korea.

Specific mutations in the hepatitis B virus (HBV) genome have been reported to

be associated with the development of hepatocellular carcinoma (HCC). The goal

of this study was to determine whether mutations in the HBV X gene are

associated with the development of HCC in hepatitis B patients with cirrhosis.

Forty-two patients infected with HBV genotype C2 with cirrhosis and HCC were

compared with 46 patients with cirrhosis but without HCC. X gene mutations were

determined by direct sequencing in all patients. The HCC and non-HCC groups were

similar with respect to clinical characteristics, and the presence of

T1762/A1764, T1653, and V1753 mutations was not significantly different between

the two groups (P = 0.068, P = 0.097, P = 0.442, respectively). Only the B1499

mutation was associated significantly with HCC (P = 0.015) (odds ratio: 3.42,

95% CI: 1.24-9.48). In hepatitis Be antigen (HBeAg)-positive patients, advanced

age was associated significantly with HCC (P = 0.038), whereas in HBeAg-negative

patients, the B1499 mutation was associated more significantly with HCC (P =

0.01). Patients in the B1499 mutation group exhibited significantly higher AST

and ALT levels compared with patients infected the wild-type virus. In

conclusion, B1499 is a novel mutation associated with HCC in Korean patients

with cirrhosis infected with HBV genotype C2.

PMID: 19697408 [PubMed - in process]