Visceral adiposity index is associated with histological findings and with high viral load in patients with chronic hepatitis C due to genotype 1â€

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http://onlinelibrary.wiley.com/doi/10.1002/hep.23859/abstract

Visceral adiposity index is associated with histological findings and with high

viral load in patients with chronic hepatitis C due to genotype 1†

Salvatore Petta1,*,‡, Marco Amato2, a Cabibi3, Calogero Cammà1, Vito Di

Marco1, Carla Giordano2, Aldo Galluzzo2, Craxì1DOI: 10.1002/hep.23859

Copyright © 2010 American Association for the Study of Liver Diseases

Issue

Hepatology

Abstract

Background and Aims:

Metabolic factors have been associated with liver damage in patients with

genotype 1 chronic hepatitis C (G1 CHC). We tested visceral adiposity index

(VAI), a new marker of adipose dysfunction in G1 CHC patients to assess its

association with host and viral factors, and its link to both histological

findings and sustained virologic response (SVR).

Materials and Methods:

Two hundred thirty-six consecutive G1 CHC patients were evaluated by liver

biopsy and anthropometric and metabolic measurements, including IR, the

homeostasis model assessment (HOMA), and VAI by using waist circumference, body

mass index, triglycerides and HDL. All biopsies were scored by one pathologist

for staging and grading (Scheuer), and graded for steatosis, which was

considered moderate-severe if ≥30%.

Results:

VAI score was independently associated with higher HOMA score (p=0.009), higher

Log10 HCV RNA levels (p=0.01), necroinflammatory activity (p=0.04), and

steatosis (p=0.04), by multiple linear regression analysis. IR (OR 3.879,95%CI

1.727–8.713, p=0.001), higher VAI score (OR 1.472,95%CI 1.051–2.062,

p=0.02), and fibrosis (OR 2.255,95%CI 1.349–3.768, p=0.002) were linked to

steatosis ≥30% by multiple logistic regression analysis. Older age (OR

1.030;95% CI 1.002-1.059; p=0.03), high VAI score (OR 1.618;95%CI 1.001-2.617;

p=0.04) and fibrosis (OR 2.608;95%CI 1.565-4.345; p<0.001) were independently

associated with moderate-severe necroinflammatory activity by logistic

regression analysis. No independent associations were found between VAI score

and both fibrosis and SVR.

Conclusion:

In G1 CHC patients, higher VAI score, a new index of adipose dysfunction, is

independently associated with both steatosis and necroinflammatory activity, and

has a direct correlation with viral load. (HEPATOLOGY 2010.)

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1002/hep.23859/abstract

Visceral adiposity index is associated with histological findings and with high

viral load in patients with chronic hepatitis C due to genotype 1†

Salvatore Petta1,*,‡, Marco Amato2, a Cabibi3, Calogero Cammà1, Vito Di

Marco1, Carla Giordano2, Aldo Galluzzo2, Craxì1DOI: 10.1002/hep.23859

Copyright © 2010 American Association for the Study of Liver Diseases

Issue

Hepatology

Abstract

Background and Aims:

Metabolic factors have been associated with liver damage in patients with

genotype 1 chronic hepatitis C (G1 CHC). We tested visceral adiposity index

(VAI), a new marker of adipose dysfunction in G1 CHC patients to assess its

association with host and viral factors, and its link to both histological

findings and sustained virologic response (SVR).

Materials and Methods:

Two hundred thirty-six consecutive G1 CHC patients were evaluated by liver

biopsy and anthropometric and metabolic measurements, including IR, the

homeostasis model assessment (HOMA), and VAI by using waist circumference, body

mass index, triglycerides and HDL. All biopsies were scored by one pathologist

for staging and grading (Scheuer), and graded for steatosis, which was

considered moderate-severe if ≥30%.

Results:

VAI score was independently associated with higher HOMA score (p=0.009), higher

Log10 HCV RNA levels (p=0.01), necroinflammatory activity (p=0.04), and

steatosis (p=0.04), by multiple linear regression analysis. IR (OR 3.879,95%CI

1.727–8.713, p=0.001), higher VAI score (OR 1.472,95%CI 1.051–2.062,

p=0.02), and fibrosis (OR 2.255,95%CI 1.349–3.768, p=0.002) were linked to

steatosis ≥30% by multiple logistic regression analysis. Older age (OR

1.030;95% CI 1.002-1.059; p=0.03), high VAI score (OR 1.618;95%CI 1.001-2.617;

p=0.04) and fibrosis (OR 2.608;95%CI 1.565-4.345; p<0.001) were independently

associated with moderate-severe necroinflammatory activity by logistic

regression analysis. No independent associations were found between VAI score

and both fibrosis and SVR.

Conclusion:

In G1 CHC patients, higher VAI score, a new index of adipose dysfunction, is

independently associated with both steatosis and necroinflammatory activity, and

has a direct correlation with viral load. (HEPATOLOGY 2010.)

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1002/hep.23859/abstract

Visceral adiposity index is associated with histological findings and with high

viral load in patients with chronic hepatitis C due to genotype 1†

Salvatore Petta1,*,‡, Marco Amato2, a Cabibi3, Calogero Cammà1, Vito Di

Marco1, Carla Giordano2, Aldo Galluzzo2, Craxì1DOI: 10.1002/hep.23859

Copyright © 2010 American Association for the Study of Liver Diseases

Issue

Hepatology

Abstract

Background and Aims:

Metabolic factors have been associated with liver damage in patients with

genotype 1 chronic hepatitis C (G1 CHC). We tested visceral adiposity index

(VAI), a new marker of adipose dysfunction in G1 CHC patients to assess its

association with host and viral factors, and its link to both histological

findings and sustained virologic response (SVR).

Materials and Methods:

Two hundred thirty-six consecutive G1 CHC patients were evaluated by liver

biopsy and anthropometric and metabolic measurements, including IR, the

homeostasis model assessment (HOMA), and VAI by using waist circumference, body

mass index, triglycerides and HDL. All biopsies were scored by one pathologist

for staging and grading (Scheuer), and graded for steatosis, which was

considered moderate-severe if ≥30%.

Results:

VAI score was independently associated with higher HOMA score (p=0.009), higher

Log10 HCV RNA levels (p=0.01), necroinflammatory activity (p=0.04), and

steatosis (p=0.04), by multiple linear regression analysis. IR (OR 3.879,95%CI

1.727–8.713, p=0.001), higher VAI score (OR 1.472,95%CI 1.051–2.062,

p=0.02), and fibrosis (OR 2.255,95%CI 1.349–3.768, p=0.002) were linked to

steatosis ≥30% by multiple logistic regression analysis. Older age (OR

1.030;95% CI 1.002-1.059; p=0.03), high VAI score (OR 1.618;95%CI 1.001-2.617;

p=0.04) and fibrosis (OR 2.608;95%CI 1.565-4.345; p<0.001) were independently

associated with moderate-severe necroinflammatory activity by logistic

regression analysis. No independent associations were found between VAI score

and both fibrosis and SVR.

Conclusion:

In G1 CHC patients, higher VAI score, a new index of adipose dysfunction, is

independently associated with both steatosis and necroinflammatory activity, and

has a direct correlation with viral load. (HEPATOLOGY 2010.)

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1002/hep.23859/abstract

Visceral adiposity index is associated with histological findings and with high

viral load in patients with chronic hepatitis C due to genotype 1†

Salvatore Petta1,*,‡, Marco Amato2, a Cabibi3, Calogero Cammà1, Vito Di

Marco1, Carla Giordano2, Aldo Galluzzo2, Craxì1DOI: 10.1002/hep.23859

Copyright © 2010 American Association for the Study of Liver Diseases

Issue

Hepatology

Abstract

Background and Aims:

Metabolic factors have been associated with liver damage in patients with

genotype 1 chronic hepatitis C (G1 CHC). We tested visceral adiposity index

(VAI), a new marker of adipose dysfunction in G1 CHC patients to assess its

association with host and viral factors, and its link to both histological

findings and sustained virologic response (SVR).

Materials and Methods:

Two hundred thirty-six consecutive G1 CHC patients were evaluated by liver

biopsy and anthropometric and metabolic measurements, including IR, the

homeostasis model assessment (HOMA), and VAI by using waist circumference, body

mass index, triglycerides and HDL. All biopsies were scored by one pathologist

for staging and grading (Scheuer), and graded for steatosis, which was

considered moderate-severe if ≥30%.

Results:

VAI score was independently associated with higher HOMA score (p=0.009), higher

Log10 HCV RNA levels (p=0.01), necroinflammatory activity (p=0.04), and

steatosis (p=0.04), by multiple linear regression analysis. IR (OR 3.879,95%CI

1.727–8.713, p=0.001), higher VAI score (OR 1.472,95%CI 1.051–2.062,

p=0.02), and fibrosis (OR 2.255,95%CI 1.349–3.768, p=0.002) were linked to

steatosis ≥30% by multiple logistic regression analysis. Older age (OR

1.030;95% CI 1.002-1.059; p=0.03), high VAI score (OR 1.618;95%CI 1.001-2.617;

p=0.04) and fibrosis (OR 2.608;95%CI 1.565-4.345; p<0.001) were independently

associated with moderate-severe necroinflammatory activity by logistic

regression analysis. No independent associations were found between VAI score

and both fibrosis and SVR.

Conclusion:

In G1 CHC patients, higher VAI score, a new index of adipose dysfunction, is

independently associated with both steatosis and necroinflammatory activity, and

has a direct correlation with viral load. (HEPATOLOGY 2010.)