Aminotransferase Elevation in HIV/Hepatitis B Virus Co-infected Patients Treated

[Guest guest]

AIDS Patient Care STDS. 2006 Dec;20(12):817-22.

Case Report: Aminotransferase Elevation in HIV/Hepatitis B Virus Co-infected

Patients Treated with Two Active Hepatitis B Virus Drugs.

Jain MK, Parekh NK, Hester J, Lee WM.

Department of Internal Medicine, University of Texas Southwestern Medical

Center, Dallas, Texas.

Discerning drug hepatotoxicity from viral hepatitis flares remains an

ongoing problem unique to patients coinfected with HIV and hepatitis B

(HBV). We present three such coinfected patients who have been on two

anti-HBV agents, lamivudine and tenofovir disoproxil fumarate

simultaneously, as part of highly active antiretroviral therapy (HAART). All

three developed significant aminotransferase elevations 6-12 weeks after

initiation of HAART despite being on two active HBV drugs. Two of the three

patients were initially thought to have drug-related hepatotoxicity from HIV

medications. It seems more likely that all three patients demonstrated

hepatitis B reactivation of differing severity as the result of varying

degrees of immune recovery. Distinguishing clearly between drug-related

hepatotoxicity and hepatitis reactivation may be difficult but is important

as their clinical management differs.

PMID: 17192146 [PubMed - in process]

_________________________________________________________________

From photos to predictions, The MSN Entertainment Guide to Golden Globes has

it all. http://tv.msn.com/tv/globes2007/?icid=nctagline1

[Guest guest]

AIDS Patient Care STDS. 2006 Dec;20(12):817-22.

Case Report: Aminotransferase Elevation in HIV/Hepatitis B Virus Co-infected

Patients Treated with Two Active Hepatitis B Virus Drugs.

Jain MK, Parekh NK, Hester J, Lee WM.

Department of Internal Medicine, University of Texas Southwestern Medical

Center, Dallas, Texas.

Discerning drug hepatotoxicity from viral hepatitis flares remains an

ongoing problem unique to patients coinfected with HIV and hepatitis B

(HBV). We present three such coinfected patients who have been on two

anti-HBV agents, lamivudine and tenofovir disoproxil fumarate

simultaneously, as part of highly active antiretroviral therapy (HAART). All

three developed significant aminotransferase elevations 6-12 weeks after

initiation of HAART despite being on two active HBV drugs. Two of the three

patients were initially thought to have drug-related hepatotoxicity from HIV

medications. It seems more likely that all three patients demonstrated

hepatitis B reactivation of differing severity as the result of varying

degrees of immune recovery. Distinguishing clearly between drug-related

hepatotoxicity and hepatitis reactivation may be difficult but is important

as their clinical management differs.

PMID: 17192146 [PubMed - in process]

_________________________________________________________________

From photos to predictions, The MSN Entertainment Guide to Golden Globes has

it all. http://tv.msn.com/tv/globes2007/?icid=nctagline1

[Guest guest]

AIDS Patient Care STDS. 2006 Dec;20(12):817-22.

Case Report: Aminotransferase Elevation in HIV/Hepatitis B Virus Co-infected

Patients Treated with Two Active Hepatitis B Virus Drugs.

Jain MK, Parekh NK, Hester J, Lee WM.

Department of Internal Medicine, University of Texas Southwestern Medical

Center, Dallas, Texas.

Discerning drug hepatotoxicity from viral hepatitis flares remains an

ongoing problem unique to patients coinfected with HIV and hepatitis B

(HBV). We present three such coinfected patients who have been on two

anti-HBV agents, lamivudine and tenofovir disoproxil fumarate

simultaneously, as part of highly active antiretroviral therapy (HAART). All

three developed significant aminotransferase elevations 6-12 weeks after

initiation of HAART despite being on two active HBV drugs. Two of the three

patients were initially thought to have drug-related hepatotoxicity from HIV

medications. It seems more likely that all three patients demonstrated

hepatitis B reactivation of differing severity as the result of varying

degrees of immune recovery. Distinguishing clearly between drug-related

hepatotoxicity and hepatitis reactivation may be difficult but is important

as their clinical management differs.

PMID: 17192146 [PubMed - in process]

_________________________________________________________________

From photos to predictions, The MSN Entertainment Guide to Golden Globes has

it all. http://tv.msn.com/tv/globes2007/?icid=nctagline1

[Guest guest]

AIDS Patient Care STDS. 2006 Dec;20(12):817-22.

Case Report: Aminotransferase Elevation in HIV/Hepatitis B Virus Co-infected

Patients Treated with Two Active Hepatitis B Virus Drugs.

Jain MK, Parekh NK, Hester J, Lee WM.

Department of Internal Medicine, University of Texas Southwestern Medical

Center, Dallas, Texas.

Discerning drug hepatotoxicity from viral hepatitis flares remains an

ongoing problem unique to patients coinfected with HIV and hepatitis B

(HBV). We present three such coinfected patients who have been on two

anti-HBV agents, lamivudine and tenofovir disoproxil fumarate

simultaneously, as part of highly active antiretroviral therapy (HAART). All

three developed significant aminotransferase elevations 6-12 weeks after

initiation of HAART despite being on two active HBV drugs. Two of the three

patients were initially thought to have drug-related hepatotoxicity from HIV

medications. It seems more likely that all three patients demonstrated

hepatitis B reactivation of differing severity as the result of varying

degrees of immune recovery. Distinguishing clearly between drug-related

hepatotoxicity and hepatitis reactivation may be difficult but is important

as their clinical management differs.

PMID: 17192146 [PubMed - in process]

_________________________________________________________________

From photos to predictions, The MSN Entertainment Guide to Golden Globes has

it all. http://tv.msn.com/tv/globes2007/?icid=nctagline1