Paediatric liver transplantation: the surgical view

[Guest guest]

Postgrad Med J. 2004 Oct;80(948):571-6.

Paediatric liver transplantation: the surgical view.

Vilca-Melendez H, Heaton ND.

Liver Transplant Surgery, Institute of Liver Studies, King's College

Hospital, Denmark Hill, London SE5 9RS, UK.

Liver transplantation is the accepted treatment for a wide variety of liver

diseases in children. Over the past 10 years a number of innovative surgical

techniques have been developed to overcome the shortage of size matched

donors particularly in children less than 5 years of age. Graft and patient

survival at one year after liver transplantation has continued to improve,

and is now over 85% and higher for good risk cases. Complications are

relatively common, but provided graft function is satisfactory, long term

survival for these children is to be expected. The need for

retransplantation has fallen significantly. Causes of early mortality

include graft dysfunction and sepsis. Late mortality is due to sepsis,

post-transplant lymphoproliferative disease, and non-compliance. Long term

survival with good graft function and excellent quality of life is possible

for the majority of children undergoing liver transplantation.

Publication Types:

Review

Review, Tutorial

PMID: 15466990 [PubMed - indexed for MEDLINE]

[Guest guest]

Postgrad Med J. 2004 Oct;80(948):571-6.

Paediatric liver transplantation: the surgical view.

Vilca-Melendez H, Heaton ND.

Liver Transplant Surgery, Institute of Liver Studies, King's College

Hospital, Denmark Hill, London SE5 9RS, UK.

Liver transplantation is the accepted treatment for a wide variety of liver

diseases in children. Over the past 10 years a number of innovative surgical

techniques have been developed to overcome the shortage of size matched

donors particularly in children less than 5 years of age. Graft and patient

survival at one year after liver transplantation has continued to improve,

and is now over 85% and higher for good risk cases. Complications are

relatively common, but provided graft function is satisfactory, long term

survival for these children is to be expected. The need for

retransplantation has fallen significantly. Causes of early mortality

include graft dysfunction and sepsis. Late mortality is due to sepsis,

post-transplant lymphoproliferative disease, and non-compliance. Long term

survival with good graft function and excellent quality of life is possible

for the majority of children undergoing liver transplantation.

Publication Types:

Review

Review, Tutorial

PMID: 15466990 [PubMed - indexed for MEDLINE]

[Guest guest]

Postgrad Med J. 2004 Oct;80(948):571-6.

Paediatric liver transplantation: the surgical view.

Vilca-Melendez H, Heaton ND.

Liver Transplant Surgery, Institute of Liver Studies, King's College

Hospital, Denmark Hill, London SE5 9RS, UK.

Liver transplantation is the accepted treatment for a wide variety of liver

diseases in children. Over the past 10 years a number of innovative surgical

techniques have been developed to overcome the shortage of size matched

donors particularly in children less than 5 years of age. Graft and patient

survival at one year after liver transplantation has continued to improve,

and is now over 85% and higher for good risk cases. Complications are

relatively common, but provided graft function is satisfactory, long term

survival for these children is to be expected. The need for

retransplantation has fallen significantly. Causes of early mortality

include graft dysfunction and sepsis. Late mortality is due to sepsis,

post-transplant lymphoproliferative disease, and non-compliance. Long term

survival with good graft function and excellent quality of life is possible

for the majority of children undergoing liver transplantation.

Publication Types:

Review

Review, Tutorial

PMID: 15466990 [PubMed - indexed for MEDLINE]

[Guest guest]

Postgrad Med J. 2004 Oct;80(948):571-6.

Paediatric liver transplantation: the surgical view.

Vilca-Melendez H, Heaton ND.

Liver Transplant Surgery, Institute of Liver Studies, King's College

Hospital, Denmark Hill, London SE5 9RS, UK.

Liver transplantation is the accepted treatment for a wide variety of liver

diseases in children. Over the past 10 years a number of innovative surgical

techniques have been developed to overcome the shortage of size matched

donors particularly in children less than 5 years of age. Graft and patient

survival at one year after liver transplantation has continued to improve,

and is now over 85% and higher for good risk cases. Complications are

relatively common, but provided graft function is satisfactory, long term

survival for these children is to be expected. The need for

retransplantation has fallen significantly. Causes of early mortality

include graft dysfunction and sepsis. Late mortality is due to sepsis,

post-transplant lymphoproliferative disease, and non-compliance. Long term

survival with good graft function and excellent quality of life is possible

for the majority of children undergoing liver transplantation.

Publication Types:

Review

Review, Tutorial

PMID: 15466990 [PubMed - indexed for MEDLINE]