Review of liver injury associated with dietary supplements

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02439.x/abstract

Review of liver injury associated with dietary supplements

Felix Stickel1, Kerstin Kessebohm2, Rosemarie Weimann3, Helmut K. Seitz4Article

first published online: 11 JAN 2011

DOI: 10.1111/j.1478-3231.2010.02439.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Early View (Articles online in advance of print)

Abstract

Dietary supplements (DS) are easily available and increasingly used, and adverse

hepatic reactions have been reported following their intake. To critically

review the literature on liver injury because of DSs, delineating patterns and

mechanisms of injury and to increase the awareness towards this cause of acute

and chronic liver damage. Studies and case reports on liver injury specifically

because of DSs published between 1990 and 2010 were searched in the PubMed and

EMBASE data bases using the terms ‘dietary/nutritional supplements’, ‘adverse

hepatic reactions’, ‘liver injury’; ‘hepatitis’, ‘liver failure’, ‘vitamin A’

and ‘retinoids’, and reviewed for yet unidentified publications. Significant

liver injury was reported after intake of Herbalife® and Hydroxycut products,

tea extracts from Camellia sinensis, products containing usnic acid and high

contents of vitamin A, anabolic steroids and others. No uniform pattern of

hepatotoxicity has been identified and severity may range from asymptomatic

elevations of serum liver enzymes to hepatic failure and death. Exact estimates

on how frequent adverse hepatic reactions occur as a result of DSs cannot be

provided. Liver injury from DSs mimicking other liver diseases is increasingly

recognized. Measures to reduce risk include tighter regulation of their

production and distribution and increased awareness of users and professionals

of the potential risks.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02439.x/abstract

Review of liver injury associated with dietary supplements

Felix Stickel1, Kerstin Kessebohm2, Rosemarie Weimann3, Helmut K. Seitz4Article

first published online: 11 JAN 2011

DOI: 10.1111/j.1478-3231.2010.02439.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Early View (Articles online in advance of print)

Abstract

Dietary supplements (DS) are easily available and increasingly used, and adverse

hepatic reactions have been reported following their intake. To critically

review the literature on liver injury because of DSs, delineating patterns and

mechanisms of injury and to increase the awareness towards this cause of acute

and chronic liver damage. Studies and case reports on liver injury specifically

because of DSs published between 1990 and 2010 were searched in the PubMed and

EMBASE data bases using the terms ‘dietary/nutritional supplements’, ‘adverse

hepatic reactions’, ‘liver injury’; ‘hepatitis’, ‘liver failure’, ‘vitamin A’

and ‘retinoids’, and reviewed for yet unidentified publications. Significant

liver injury was reported after intake of Herbalife® and Hydroxycut products,

tea extracts from Camellia sinensis, products containing usnic acid and high

contents of vitamin A, anabolic steroids and others. No uniform pattern of

hepatotoxicity has been identified and severity may range from asymptomatic

elevations of serum liver enzymes to hepatic failure and death. Exact estimates

on how frequent adverse hepatic reactions occur as a result of DSs cannot be

provided. Liver injury from DSs mimicking other liver diseases is increasingly

recognized. Measures to reduce risk include tighter regulation of their

production and distribution and increased awareness of users and professionals

of the potential risks.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02439.x/abstract

Review of liver injury associated with dietary supplements

Felix Stickel1, Kerstin Kessebohm2, Rosemarie Weimann3, Helmut K. Seitz4Article

first published online: 11 JAN 2011

DOI: 10.1111/j.1478-3231.2010.02439.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Early View (Articles online in advance of print)

Abstract

Dietary supplements (DS) are easily available and increasingly used, and adverse

hepatic reactions have been reported following their intake. To critically

review the literature on liver injury because of DSs, delineating patterns and

mechanisms of injury and to increase the awareness towards this cause of acute

and chronic liver damage. Studies and case reports on liver injury specifically

because of DSs published between 1990 and 2010 were searched in the PubMed and

EMBASE data bases using the terms ‘dietary/nutritional supplements’, ‘adverse

hepatic reactions’, ‘liver injury’; ‘hepatitis’, ‘liver failure’, ‘vitamin A’

and ‘retinoids’, and reviewed for yet unidentified publications. Significant

liver injury was reported after intake of Herbalife® and Hydroxycut products,

tea extracts from Camellia sinensis, products containing usnic acid and high

contents of vitamin A, anabolic steroids and others. No uniform pattern of

hepatotoxicity has been identified and severity may range from asymptomatic

elevations of serum liver enzymes to hepatic failure and death. Exact estimates

on how frequent adverse hepatic reactions occur as a result of DSs cannot be

provided. Liver injury from DSs mimicking other liver diseases is increasingly

recognized. Measures to reduce risk include tighter regulation of their

production and distribution and increased awareness of users and professionals

of the potential risks.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02439.x/abstract

Review of liver injury associated with dietary supplements

Felix Stickel1, Kerstin Kessebohm2, Rosemarie Weimann3, Helmut K. Seitz4Article

first published online: 11 JAN 2011

DOI: 10.1111/j.1478-3231.2010.02439.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Early View (Articles online in advance of print)

Abstract

Dietary supplements (DS) are easily available and increasingly used, and adverse

hepatic reactions have been reported following their intake. To critically

review the literature on liver injury because of DSs, delineating patterns and

mechanisms of injury and to increase the awareness towards this cause of acute

and chronic liver damage. Studies and case reports on liver injury specifically

because of DSs published between 1990 and 2010 were searched in the PubMed and

EMBASE data bases using the terms ‘dietary/nutritional supplements’, ‘adverse

hepatic reactions’, ‘liver injury’; ‘hepatitis’, ‘liver failure’, ‘vitamin A’

and ‘retinoids’, and reviewed for yet unidentified publications. Significant

liver injury was reported after intake of Herbalife® and Hydroxycut products,

tea extracts from Camellia sinensis, products containing usnic acid and high

contents of vitamin A, anabolic steroids and others. No uniform pattern of

hepatotoxicity has been identified and severity may range from asymptomatic

elevations of serum liver enzymes to hepatic failure and death. Exact estimates

on how frequent adverse hepatic reactions occur as a result of DSs cannot be

provided. Liver injury from DSs mimicking other liver diseases is increasingly

recognized. Measures to reduce risk include tighter regulation of their

production and distribution and increased awareness of users and professionals

of the potential risks.