Hepatitis B virus genotypes and evolutionary profiles of blood donors from Northwest region of China

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Hepatitis B virus genotypes and evolutionary profiles of blood donors from

Northwest region of China

Hepatitis B virus (HBV) is prevalent in China and screening of blood donors is

mandatory. Up to now, ELISA has been universally used by the China blood bank.

However, this strategy has sometimes failed due to the high frequency of

nucleoside acid mutations. Understanding HBV evolution and strain diversity

could help devise a better screening system for blood donors.

However, this kind of information in China, especially in the northwest region,

is lacking. In the present study, serological markers and the HBV DNA load of 11

samples from blood donor candidates from northwest China were determined.

The HBV strains were most clustered into B and C genotypes and could not be

clustered into similar types from reference sequences. Subsequent testing showed

liver function impairment and increasing virus load in the positive donors.

This HBV evolutionary data for China will allow for better ELISA and NAT

screening efficiency in the blood bank of China, especially in the northwest

region.

Author: Xing-bin HuQiao-hong YueXian-qing ZhangXue-qing XuWen YinYao-zhen

ChenXiao-dong ChengLiu YangShi-jie Mu

Credits/Source: Virology Journal 2009, 6:199

[Guest guest]

http://7thspace.com/headlines/325765/hepatitis_b_virus_genotypes_and_evolutionar\

y_profiles_of_blood_donors_from_northwest_region_of_china.html

Hepatitis B virus genotypes and evolutionary profiles of blood donors from

Northwest region of China

Hepatitis B virus (HBV) is prevalent in China and screening of blood donors is

mandatory. Up to now, ELISA has been universally used by the China blood bank.

However, this strategy has sometimes failed due to the high frequency of

nucleoside acid mutations. Understanding HBV evolution and strain diversity

could help devise a better screening system for blood donors.

However, this kind of information in China, especially in the northwest region,

is lacking. In the present study, serological markers and the HBV DNA load of 11

samples from blood donor candidates from northwest China were determined.

The HBV strains were most clustered into B and C genotypes and could not be

clustered into similar types from reference sequences. Subsequent testing showed

liver function impairment and increasing virus load in the positive donors.

This HBV evolutionary data for China will allow for better ELISA and NAT

screening efficiency in the blood bank of China, especially in the northwest

region.

Author: Xing-bin HuQiao-hong YueXian-qing ZhangXue-qing XuWen YinYao-zhen

ChenXiao-dong ChengLiu YangShi-jie Mu

Credits/Source: Virology Journal 2009, 6:199