Autoimmunity caused by over-stimulating the host’s immune ‘system’ by repeated immunization with antigen

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http://elitestv.com/pub/2009/12/self-organized-criticality-theory-of-autoimmunity

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Science/Tech/Health / Self-Organized Criticality Theory of

Autoimmunity

Self-Organized Criticality Theory of Autoimmunity

By PLoS ONE • on

December 31, 2009

Background

The cause of autoimmunity, which is unknown, is investigated from a

different angle, i.e., the defect in immune ‘system’, to explain the

cause of autoimmunity.

Methodology/Principal Findings

Repeated immunization with

antigen causes systemic autoimmunity in

mice otherwise not prone to spontaneous

autoimmune diseases. Overstimulation of

CD4+ T cells led to the

development of autoantibody-inducing

CD4+ T (aiCD4+ T) cell which had undergone T

cell receptor (TCR) revision and was capable of inducing autoantibodies.

The aiCD4+ T cell was induced by de novo TCR

revision but not by cross-reaction, and subsequently overstimulated

CD8+ T cells, driving them to become antigen-specific

cytotoxic T lymphocytes (CTL). These CTLs could be further matured by

antigen cross-presentation, after which they caused autoimmune tissue

injury akin to systemic lupus

erythematosus (SLE).

Conclusions/Significance

Systemic autoimmunity appears to be the inevitable consequence of

over-stimulating the host’s immune ‘system’ by repeated immunization with

antigen, to the levels that surpass system’s self-organized

criticality.

For the full article visit:

Self-Organized Criticality Theory of Autoimmunity

Syndicated from:PLoS ONE

Article is licensed under a

Creative Commons

Attribution License.

Sheri Nakken, R.N., MA, Hahnemannian

Homeopath

Vaccination Information & Choice Network, Washington State, USA

Vaccines -

http://vaccinationdangers.wordpress.com/

Vaccine Dangers, Childhood Disease Classes & Homeopathy

Online/email courses - next classes start January 6 & 7

http://www.wellwithin1.com/vaccineclass.htm or

http://www.wellwithin1.com/homeo.htm

[Guest guest]

http://elitestv.com/pub/2009/12/self-organized-criticality-theory-of-autoimmunity

Home /

PLoS

ONE,

Science/Tech/Health / Self-Organized Criticality Theory of

Autoimmunity

Self-Organized Criticality Theory of Autoimmunity

By PLoS ONE • on

December 31, 2009

Background

The cause of autoimmunity, which is unknown, is investigated from a

different angle, i.e., the defect in immune ‘system’, to explain the

cause of autoimmunity.

Methodology/Principal Findings

Repeated immunization with

antigen causes systemic autoimmunity in

mice otherwise not prone to spontaneous

autoimmune diseases. Overstimulation of

CD4+ T cells led to the

development of autoantibody-inducing

CD4+ T (aiCD4+ T) cell which had undergone T

cell receptor (TCR) revision and was capable of inducing autoantibodies.

The aiCD4+ T cell was induced by de novo TCR

revision but not by cross-reaction, and subsequently overstimulated

CD8+ T cells, driving them to become antigen-specific

cytotoxic T lymphocytes (CTL). These CTLs could be further matured by

antigen cross-presentation, after which they caused autoimmune tissue

injury akin to systemic lupus

erythematosus (SLE).

Conclusions/Significance

Systemic autoimmunity appears to be the inevitable consequence of

over-stimulating the host’s immune ‘system’ by repeated immunization with

antigen, to the levels that surpass system’s self-organized

criticality.

For the full article visit:

Self-Organized Criticality Theory of Autoimmunity

Syndicated from:PLoS ONE

Article is licensed under a

Creative Commons

Attribution License.

Sheri Nakken, R.N., MA, Hahnemannian

Homeopath

Vaccination Information & Choice Network, Washington State, USA

Vaccines -

http://vaccinationdangers.wordpress.com/

Vaccine Dangers, Childhood Disease Classes & Homeopathy

Online/email courses - next classes start January 6 & 7

http://www.wellwithin1.com/vaccineclass.htm or

http://www.wellwithin1.com/homeo.htm

[Guest guest]

I'm a little confused by the language of this article? Is it suggesting that

all autoimmune disease- allergies, eczema...could also be caused by

immunizations? All of us here know it is but is this article suggesting it too?

>

>

http://elitestv.com/pub/2009/12/self-organized-criticality-theory-of-autoimmunit\

y

>

> Home /

> <http://elitestv.com/pub/category/syndication/plos-one>PLoS

> ONE,

> <http://elitestv.com/pub/category/science-tech-health>Science/Tech/Health

> / Self-Organized Criticality Theory of Autoimmunity

>

> Self-Organized Criticality Theory of Autoimmunity

>

>

> By <http://elitestv.com/pub/author/plos-one/>PLoS ONE • on December 31, 2009

>

> Background

>

> The cause of autoimmunity, which is unknown, is

> investigated from a different angle, i.e., the

> defect in immune `system', to explain the cause of autoimmunity.

>

> Methodology/Principal Findings

>

> Repeated immunization with

>

<http://elitestv.com/pub/2009/12/self-organized-criticality-theory-of-autoimmuni\

ty#>antigen

> causes systemic autoimmunity in mice otherwise

> not prone to spontaneous

>

<http://elitestv.com/pub/2009/12/self-organized-criticality-theory-of-autoimmuni\

ty#>autoimmune

> diseases. Overstimulation of CD4+ T cells led to

> the

>

<http://elitestv.com/pub/2009/12/self-organized-criticality-theory-of-autoimmuni\

ty#>development

> of autoantibody-inducing CD4+ T (aiCD4+ T) cell

> which had undergone T cell receptor (TCR)

> revision and was capable of inducing

> autoantibodies. The aiCD4+ T cell was induced by

> de novo TCR revision but not by cross-reaction,

> and subsequently overstimulated CD8+ T cells,

> driving them to become antigen-specific cytotoxic

> T lymphocytes (CTL). These CTLs could be further

> matured by antigen cross-presentation, after

> which they caused autoimmune tissue

>

<http://elitestv.com/pub/2009/12/self-organized-criticality-theory-of-autoimmuni\

ty#>injury

> akin to systemic lupus erythematosus (SLE).

>

> Conclusions/Significance

>

> Systemic autoimmunity appears to be the

> inevitable consequence of over-stimulating the

> host's immune `system' by repeated immunization

> with antigen, to the levels that surpass system's self-organized criticality.

>

> For the full article visit:

>

<http://feedproxy.google.com/%7Er/plosone/PLoSONE/%7E3/vez0xZQ0OIc/info:doi/10.1\

371/journal.pone.0008382>Self-Organized

> Criticality Theory of Autoimmunity

> Syndicated from:<http://www.plosone.org>PLoS ONE

>

> Article is licensed under a

> <http://creativecommons.org/licenses/by/2.5/>Creative

> Commons Attribution License.

>

> Sheri Nakken, R.N., MA, Hahnemannian Homeopath

> Vaccination Information & Choice Network, Washington State, USA

> Vaccines - http://vaccinationdangers.wordpress.com/

> Vaccine Dangers, Childhood Disease Classes &

> Homeopathy Online/email courses - next classes start January 6 & 7

> http://www.wellwithin1.com/vaccineclass.htm or

> http://www.wellwithin1.com/homeo.htm

>