Fw: More On ... The Transfer of Drugs and Other Chemicals Into Human Milk ~ including silicone implants

[Guest guest]

From: " ilena rose " <ilena@...>

Sent: Wednesday, September 05, 2001 10:30 AM

Subject: More On ... The Transfer of Drugs and Other Chemicals Into Human

Milk ~ including silicone implants

Please send out for me:

Very creatively written. If you read the key phrases, you will see the

actual

message in this journalistic approach to the " truth " . I have listed some of

the " key " phrases from the article below concerning BI. Very cleverly

written

to put a smoke screen up to hide the true meaning which is:

1. " This has YET to be confirmed "

2. " The committe does not FEEL "

3. " This finding has NOT been CONFIRMED " (as in, " we really don't know " )

4. " POSSIBLE effects "

5. " There is no evidence AT THE PRESENT TIME "

6. " However, concern also arises that toxicity MAY BE mediated through the

immune system " .

THERE HAVE NEVER BEEN ANY LONG TERM STUDYS TO VERIFY THAT THESE DIVICES ARE

SAFE FOR BABIES WHO ARE BEING BREAST FED, OR TO MOTHERS WHO MAY BE WORRIED

ABOUT CHANGES IN THEIR DNA. ANYONE WHO WOULD " PEN " THIS STORY AND SEND IT

OUT

WITH IT'S OBVIOUS SMOKE SCREEN IS NOT GIVING THE PUBLIC A TRUE STORY...I

have

already read about the possible impact that polyurethane has on human DNA.

~~~~~~~~~~~~~~

Implants not seen as harmful to breastfeeding baby Release at 5 p.m.

EDT CHICAGO (Reuters) - In a review of breast milk safety, a

pediatricians group said Tuesday that mothers with silicone breast

implants can safely breast-feed though some prescription drugs might taint

their milk. The American Academy of Pediatrics committee's report said it

was not possible to predict the long-term effects on breast-feeding

infants of anti-anxiety drugs, antidepressants and some other drugs that

usually appear in low concentrations in the breast milk of mothers taking

the prescription drugs. " Because these drugs affect neurotransmitter

function in the developing central nervous system, it may not be possible

to predict long-term neurodevelopmental effects, " the report cautioned.

Mothers who breast-feed can take precautions such as taking the safest drug

possible, taking the medication just after breast-feeding, or having the

infant's blood checked for drug concentrations. Based on previous

studies, the report said breast implants present little or no threat to

breast-feeding infants, although one study noted a problem with some

babies' esophageal function. Up to 1 million American women have breast

implants containing silicone. The report, published in the journal

Pediatrics, was a summary of several previously-done studies. The report

noted that substances similar to silicone are found in cow's milk, infant

formula and in the anticolic compound simethicone, with no ill effects.

~~~~~~~~~~~~~~~~~~~~

Ilena Rose wrote:

>

> SWEETCAROLINELV@... wrote:

>

> GO DOWN AND SEE WHO GAVE THE INFO ON SILICON AND USED THAT TO COME TO

> THE CONCLUSIONS --THE PLASTIC SURGEONS-----SOMETHING HAS TO BE DONE

> ABOUTTHIS OR ALOT OF YOUNG WOMEN ARE GOING TO HARM THEIR CHILDREN AND

> THE DRS WONT EVEN KNOW WHAT TO DO ----OR BELIEVE THEIR INJURYS

> --CAROLINE

>

> ~~~~~~~~~~~~~~~~~~~~~~~~~

>

> " sey " <fuchsmorrissey@...> wrote:

>

> ILENA/KATHY, Ladies~ if breast implants are safe, with acceptable risks

> then the FDA should give their FDA approval for all breast implants with

or

> without a genetic predisposition/genetic susceptibility. Why have they not

> done this? CFM

> ~~~~~~~~~~~~~~~~~~~~~~~~~

>

> I think this is more corporate " tobacco

> science " and " silicone science " ... bound to put true science back a few

> decades. Ilena ~~~

>

> http://www.aap.org/policy/0063.html

>

> The Transfer of Drugs and Other Chemicals Into Human Milk

>

> AMERICAN ACADEMY OF PEDIATRICS

>

> Committee on Drugs

>

> ABSTRACT. The American Academy of Pediatrics places emphasis on increasing

> breastfeeding in the United States. A common reason for the cessation of

> breastfeeding is the use of medication by the nursing mother and advice by

> her physician to stop nursing. Such advice may not be warranted. This

> statement is intended to supply the pediatrician, obstetrician, and family

> physician with data, if known, concerning the excretion of drugs into

> human milk. Most drugs likely to be prescribed to the nursing mother

> should have no effect on milk supply or on infant well-being. This

> information is important not only to protect nursing infants from untoward

> effects of maternal medication but also to allow effective pharmacologic

> treatment of breastfeeding mothers. Nicotine, psychotropic drugs, and

> silicone implants are 3 important topics reviewed in this statement.

>

> INTRODUCTION

>

> A statement on the transfer of drugs and chemicals into human milk was

> first published in 1983,1 with revisions in 19892 and 1994.3 Information

> continues to become available. The current statement is intended to revise

> the lists of agents transferred into human milk and describe their

> possible effects on the infant or on lactation, if known (Tables 1-7). If

> a pharmacologic or chemical agent does not appear in the tables, it does

> not mean that it is not transferred into human milk or that it does not

> have an effect on the infant; it only indicates that there were no reports

> found in the literature. These tables should assist the physician in

> counseling a nursing mother regarding breastfeeding when the mother has a

> condition for which a drug is medically indicated.

>

> BREASTFEEDING AND SMOKING

>

> In the previous edition of this statement, the Committee on Drugs placed

> nicotine (smoking) in Table 2, " Drugs of Abuse for Which Adverse Effects

> on the Infant During Breastfeeding Have Been Reported. " The reasons for

> placing nicotine and, thus, smoking in Table 2 were documented decrease in

> milk production and weight gain in the infant of the smoking mother and

> exposure of the infant to environmental tobacco smoke as demonstrated by

> the presence of nicotine and its primary metabolite, cotinine, in human

> milk.4-12 There is controversy regarding the effects of nicotine on infant

> size at 1 year of age.13,14 There are hundreds of compounds in tobacco

> smoke; however, nicotine and its metabolite cotinine are most often used

> as markers of tobacco exposure. Nicotine is not necessarily the only

> component that might cause an increase in respiratory illnesses (including

> otitis media) in the nursing infant attributable to both transmammary

> secretion of compounds and environmental exposure. Nicotine is present in

> milk in concentrations between 1.5 and 3.0 times the simultaneous maternal

> plasma concentration,15 and elimination half-life is similar-60 to 90

> minutes in milk and plasma.7 There is no evidence to document whether this

> amount of nicotine presents a health risk to the nursing infant.

>

> The Committee on Drugs wishes to support the emphasis of the American

> Academy of Pediatrics on increasing breastfeeding in the United States.

> Pregnancy and lactation are ideal occasions for physicians to urge

> cessation of smoking. It is recognized that there are women who are unable

> to stop smoking cigarettes. One study reported that, among women who

> continue to smoke throughout breastfeeding, the incidence of acute

> respiratory illness is decreased among their infants, compared with

> infants of smoking mothers who are bottle fed.16 It may be that

> breastfeeding and smoking is less detrimental to the child than bottle

> feeding and smoking. The Committee on Drugs awaits more data on this

> issue. The Committee on Drugs therefore has not placed nicotine (and thus

> smoking) in any of the Tables but hopes that the interest in breastfeeding

> by a smoking woman will serve as a point of discussion about smoking

> cessation between the pediatrician and the prospective lactating woman or

> nursing mother. Alternate (oral, transcutaneous) sources of nicotine to

> assist with smoking cessation, however, have not been studied sufficiently

> for the Committee on Drugs to make a recommendation for or against them in

> breastfeeding women.

>

> PSYCHOTROPIC DRUGS

>

> Anti-anxiety drugs, antidepressants, and neuroleptic drugs have been

> placed in Table 4, " Drugs for Which the Effect on Nursing Infants Is

> Unknown but May Be of Concern. " These drugs appear in low concentrations

> (usually with a milk-to-plasma ratio of 0.5-1.0) in milk after maternal

> ingestion. Because of the long half-life of these compounds and some of

> their metabolites, nursing infants may have measurable amounts in their

> plasma and tissues, such as the brain. This is particularly important in

> infants during the first few months of life, with immature hepatic and

> renal function. Nursing mothers should be informed that if they take one

> of these drugs, the infant will be exposed to it. Because these drugs

> affect neurotransmitter function in the developing central nervous system,

> it may not be possible to predict long-term neurodevelopmental effects.

>

> SILICONE BREAST IMPLANTS AND BREASTFEEDING

>

> Approximately 800 000 to 1 million women in the United States have

> received breast implants containing silicone (elemental silicon with

> chemical bonds to oxygen) in the implant envelope or in the envelope and

> the interior gel. Concern has been raised about the possible effects to

> the nursing infant if mothers with implants breastfeed. This concern was

> initially raised in reports that described esophageal dysfunction in 11

> children whose mothers had implants.17,18 This finding has not been

> confirmed by other reports. Silicone chemistry is extremely complex; the

> polymer involved in the covering and the interior of the breast implant

> consists of a polymer of alternating silicon and oxygen atoms with methyl

> groups attached to the oxygen groups (methyl polydimethylsiloxane).19 The

> length of the polymer determines whether it is a solid, gel, or liquid.

> There are only a few instances of the polymer being assayed in the milk of

> women with implants; the concentrations are not elevated over control

> samples.20 There is no evidence at the present time that this polymer is

> directly toxic to human tissues; however, concern also exists that

> toxicity may be mediated through an immunologic mechanism. This has yet to

> be confirmed in humans. Except for the study cited above, there have been

> no other reports of clinical problems in infants of mothers with silicone

> breast implants.21 It is unlikely that elemental silicon causes

> difficulty, because silicon is present in higher concentrations in cow

> milk and formula than in milk of humans with implants.22 The anticolic

> compound simethicone is a silicone and has a structure very similar to the

> methyl polydimethylsiloxane in breast implants. Simethicone has been used

> for decades in this country and Europe without any evidence of toxicity to

> infants. The Committee on Drugs does not feel that the evidence currently

> justifies classifying silicone implants as a contraindication to

> breastfeeding.

>

> DRUG THERAPY OF THE LACTATING WOMAN

>

> The following should be considered before prescribing drugs to lactating

>women:

>

> 1. Is drug therapy really necessary? If drugs are required, consultation

> between the pediatrician and the mother's physician can be most useful in

> determining what options to choose.

> 2. The safest drug should be chosen, for example, acetaminophen rather

> than aspirin for analgesia.

> 3. If there is a possibility that a drug may present a risk to the infant,

> consideration should be given to measurement of blood concentrations in

> the nursing infant.

> 4. Drug exposure to the nursing infant may be minimized by having the

> mother take the medication just after she has breastfed the infant or just

> before the infant is due to have a lengthy sleep period.

>

> Data have been obtained from a search of the medical literature. Because

> methodologies used to quantitate drugs in milk continue to improve, this

> information will require frequent updating. Drugs cited in Tables 1

> through 7 are listed in alphabetical order by generic name; brand names

> are available from the current Physicians' Desk Reference,23 USP DI 2001:

> Drug Information for the Health Care Professional, Volume I,24 and USP

> Dictionary of USAN and International Drug Names.25 The reference list is

> not inclusive of all articles published on the topic.

>

> Physicians who encounter adverse effects in infants who have been

> receiving drug-contaminated human milk are urged to document these effects

> in a communication to the Food and Drug Administration

> (http://www.fda.gov/medwatch/index.html) and to the Committee on Drugs.

> This communication should include the generic and brand names of the drug,

> the maternal dose and mode of administration, the concentration of the

> drug in milk and maternal and infant blood in relation to the time of

> ingestion, the method used for laboratory identification, the age of the

> infant, and the adverse effects. Such reports may substantially increase

> the pediatric community's fund of knowledge regarding drug transfer into

> human milk and the potential or actual risk to the infant.

>

> COMMITTEE ON DRUGS, 2000-2001

> M. Ward, MD, Chairperson

> A. Bates, MD

> E. Benitz, MD

> J. Burchfield, MD

> C. Ring, MD

> P. Walls, MD, PhD

> Philip D. Walson, MD

> LIAISONS

> , MD

> ÝÝFood and Drug Administration Alternate

> R. , MD, PhD

> ÝÝAmerican Medical Association/United States Pharmacopeia

> Therese Cvetkovich, MD

> ÝÝFood and Drug Administration

> Owen R. Hagino, MD

> ÝÝAmerican Academy of Child and Adolescent Psychiatry

> Stuart M. MacLeod, MD, PhD

> ÝÝCanadian Paediatric Society

> Siddika Mithani, MD

> ÝÝBureau of Pharmaceutical Assessment Health Protection Branch, Canada

> ph Mulinare, MD, MSPH

> ÝÝCenters for Disease Control and Prevention

> E. Riley, MD

> ÝÝAmerican College of Obstetricians and Gynecologists

> Sumner J. Yaffe, MD

> ÝÝNational Institutes of Health

>

> SECTION LIAISONS

> J. CotÈ, MD

> ÝÝSection on Anesthesiology

> Eli O. Meltzer, MD

> ÝÝSection on Allergy and Immunology

>

> CONSULTANT

> Cheston M. Berlin, Jr, MD

>

> STAFF

> J. Koteras, MHA

>

> ACKNOWLEDGMENT