Guest guest Posted January 4, 2001 Report Share Posted January 4, 2001 article excerpt: Mitochondrial Toxicity in HCV Infection There was probably one abstract that I thought was not related to HIV but may actually come around back again to be important. That is, there was an Irish abstract about hepatitis C causing deletions in mitochondrial DNA in actually 60 percent of the patients who had hepatitis C. That sort of supports a previous study that was published in 1999 that showed 90 percent of the people with hepatitis C had mitochondrial abnormalities. As most of the audience may know, one of the major issues nowadays with our long-term use of nucleoside analogs is mitochondrial toxicity. If these findings are indeed true-and now there are two studies-that hepatitis C may be injuring mitochondria and setting up the liver cells for mitochondrial toxicity and more liver toxicity of nucleoside analogs. So I think we have to be more vigilant now of both nucleoside analog liver toxicity, protease inhibitor toxicity with this new " ballooning " finding, and of course the non-nuke hepatotoxicity-whatever is really causing that. It seems to be more common in women and that would argue that it's a hypersensitivity allergic type thing. Alley/Pat alleypat@... DFW Liver Disease Newsletter http://community.dallasnews.com/dmn/dfwliver Men occasionally stumble over the truth, but most pick themselves up and hurry off as if nothing has happened. " ---Winston Churchill Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2001 Report Share Posted January 4, 2001 article excerpt: Mitochondrial Toxicity in HCV Infection There was probably one abstract that I thought was not related to HIV but may actually come around back again to be important. That is, there was an Irish abstract about hepatitis C causing deletions in mitochondrial DNA in actually 60 percent of the patients who had hepatitis C. That sort of supports a previous study that was published in 1999 that showed 90 percent of the people with hepatitis C had mitochondrial abnormalities. As most of the audience may know, one of the major issues nowadays with our long-term use of nucleoside analogs is mitochondrial toxicity. If these findings are indeed true-and now there are two studies-that hepatitis C may be injuring mitochondria and setting up the liver cells for mitochondrial toxicity and more liver toxicity of nucleoside analogs. So I think we have to be more vigilant now of both nucleoside analog liver toxicity, protease inhibitor toxicity with this new " ballooning " finding, and of course the non-nuke hepatotoxicity-whatever is really causing that. It seems to be more common in women and that would argue that it's a hypersensitivity allergic type thing. Alley/Pat alleypat@... DFW Liver Disease Newsletter http://community.dallasnews.com/dmn/dfwliver Men occasionally stumble over the truth, but most pick themselves up and hurry off as if nothing has happened. " ---Winston Churchill Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2001 Report Share Posted January 4, 2001 erm......... This looks really interesting and I would like to understand it but I can't so can anyone provide an idiot's guide translation please? love Sylv what is mitochondrial > > article excerpt: > > Mitochondrial Toxicity in HCV Infection > > There was probably one abstract that I thought was not related to HIV but may actually come around back again to be important. That is, there was an Irish abstract about hepatitis C causing deletions in mitochondrial DNA in actually 60 percent of the patients who had hepatitis C. That sort of supports a previous study that was published in 1999 that showed 90 percent of the people with hepatitis C had mitochondrial abnormalities. > > As most of the audience may know, one of the major issues nowadays with our long-term use of nucleoside analogs is mitochondrial toxicity. If these findings are indeed true-and now there are two studies-that hepatitis C may be injuring mitochondria and setting up the liver cells for mitochondrial toxicity and more liver toxicity of nucleoside analogs. So I think we have to be more vigilant now of both nucleoside analog liver toxicity, protease inhibitor toxicity with this new " ballooning " finding, and of course the non-nuke hepatotoxicity-whatever is really causing that. It seems to be more common in women and that would argue that it's a hypersensitivity allergic type thing. > > > > Alley/Pat > alleypat@... > DFW Liver Disease Newsletter > http://community.dallasnews.com/dmn/dfwliver > > Men occasionally stumble over the truth, but most pick themselves up and hurry off as if nothing has happened. " ---Winston Churchill > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2001 Report Share Posted January 4, 2001 erm......... This looks really interesting and I would like to understand it but I can't so can anyone provide an idiot's guide translation please? love Sylv what is mitochondrial > > article excerpt: > > Mitochondrial Toxicity in HCV Infection > > There was probably one abstract that I thought was not related to HIV but may actually come around back again to be important. That is, there was an Irish abstract about hepatitis C causing deletions in mitochondrial DNA in actually 60 percent of the patients who had hepatitis C. That sort of supports a previous study that was published in 1999 that showed 90 percent of the people with hepatitis C had mitochondrial abnormalities. > > As most of the audience may know, one of the major issues nowadays with our long-term use of nucleoside analogs is mitochondrial toxicity. If these findings are indeed true-and now there are two studies-that hepatitis C may be injuring mitochondria and setting up the liver cells for mitochondrial toxicity and more liver toxicity of nucleoside analogs. So I think we have to be more vigilant now of both nucleoside analog liver toxicity, protease inhibitor toxicity with this new " ballooning " finding, and of course the non-nuke hepatotoxicity-whatever is really causing that. It seems to be more common in women and that would argue that it's a hypersensitivity allergic type thing. > > > > Alley/Pat > alleypat@... > DFW Liver Disease Newsletter > http://community.dallasnews.com/dmn/dfwliver > > Men occasionally stumble over the truth, but most pick themselves up and hurry off as if nothing has happened. " ---Winston Churchill > > > > > Quote Link to comment Share on other sites More sharing options...
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