Effects of lamivudine on outcome after liver resection for hepatocellular carcin

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Hepatol Res. 2007 Feb;37(2):94-100.

Effects of lamivudine on outcome after liver resection for hepatocellular

carcinoma in patients with active replication of hepatitis B virus.

Kubo S, Tanaka H, Takemura S, Yamamoto S, Hai S, Ichikawa T, Kodai S,

Shinkawa H, Sakaguchi H, Tamori A, Habu D, Nishiguchi S.

Departments of Hepato-Biliary-Pancreatic Surgery, Osaka City University

Graduate School of Medicine, Osaka, Japan.

Aim: Patients with high serum hepatitis B virus (HBV) DNA concentrations are

at high risk of tumor recurrence after liver resection for HBV-related

hepatocellular carcinoma (HCC). Methods: Among 24 patients with high serum

HBV DNA concentrations who underwent liver resection for HBV-related HCC,

postoperative lamivudine therapy was chosen by 14 (lamivudine group). The

other 10 patients were controls. Results: Clinicopathologic findings did not

differ between the groups. Tumor-free survival rate after surgery was

significantly higher in the lamivudine than the control group (P = 0.0086).

By univariate analysis, multiple tumors were also a risk factor for a short

tumor-free survival. By multivariate analysis, lack of lamivudine therapy

and multiple tumors were independent risk factors for a short tumor-free

survival. In four patients YMDD mutant viruses were detected after beginning

lamivudine administration; in two of them, adefovir dipivoxil was

administered because of sustained serum alanine aminotransferase elevations.

Conclusion: Lamivudine therapy improved tumor-free survival rate after

curative resection of HBV-related HCC in patients with high serum

concentrations of HBV DNA, although careful follow up proved necessary for

the detection of YMDD mutant viruses.

PMID: 17300703 [PubMed - in process]

_________________________________________________________________

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[Guest guest]

Hepatol Res. 2007 Feb;37(2):94-100.

Effects of lamivudine on outcome after liver resection for hepatocellular

carcinoma in patients with active replication of hepatitis B virus.

Kubo S, Tanaka H, Takemura S, Yamamoto S, Hai S, Ichikawa T, Kodai S,

Shinkawa H, Sakaguchi H, Tamori A, Habu D, Nishiguchi S.

Departments of Hepato-Biliary-Pancreatic Surgery, Osaka City University

Graduate School of Medicine, Osaka, Japan.

Aim: Patients with high serum hepatitis B virus (HBV) DNA concentrations are

at high risk of tumor recurrence after liver resection for HBV-related

hepatocellular carcinoma (HCC). Methods: Among 24 patients with high serum

HBV DNA concentrations who underwent liver resection for HBV-related HCC,

postoperative lamivudine therapy was chosen by 14 (lamivudine group). The

other 10 patients were controls. Results: Clinicopathologic findings did not

differ between the groups. Tumor-free survival rate after surgery was

significantly higher in the lamivudine than the control group (P = 0.0086).

By univariate analysis, multiple tumors were also a risk factor for a short

tumor-free survival. By multivariate analysis, lack of lamivudine therapy

and multiple tumors were independent risk factors for a short tumor-free

survival. In four patients YMDD mutant viruses were detected after beginning

lamivudine administration; in two of them, adefovir dipivoxil was

administered because of sustained serum alanine aminotransferase elevations.

Conclusion: Lamivudine therapy improved tumor-free survival rate after

curative resection of HBV-related HCC in patients with high serum

concentrations of HBV DNA, although careful follow up proved necessary for

the detection of YMDD mutant viruses.

PMID: 17300703 [PubMed - in process]

_________________________________________________________________

Rates near 39yr lows! $430K Loan for $1,399/mo - Paying Too Much? Calculate

new payment

http://www.lowermybills.com/lre/index.jsp?sourceid=lmb-9632-18226 & moid=7581