Accelerated hepatitis C virus kinetics but similar survival rates in recipients

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Hepatology. 2005 Dec;42(6):1420-8.

Accelerated hepatitis C virus kinetics but similar survival rates in

recipients of liver grafts from living versus deceased donors.

Schiano TD, Gutierrez JA, Walewski JL, Fiel MI, Cheng B, Bodenheimer H Jr,

Thung SN, Chung RT, Schwartz ME, Bodian C, Branch AD.

The Recanati/ Transplantation Institute, The Mount Sinai Hospital, New

York, NY.

This study tested the hypothesis that hepatitis C virus (HCV) RNA and core

antigen levels rise more rapidly after liver transplantation (LT) in

recipients of grafts from living donors (LD) versus deceased donors (DD).

Eleven consecutive LD and 15 DD recipients were followed prospectively.

Before LT, median HCV RNA levels were similar: 5.42 (LDLT) and 5.07 (DDLT)

log(10) IU/mL (P = NS). During the first 7 hours after LT a trend toward a

greater HCV RNA decrease in LDLT patients was seen, although they received

fewer blood replacement products during surgery. HCV RNA levels rose more

rapidly in LDLT patients between days 1 and 3 (P = .0059) and were higher in

this group on days 2, 3, 4, and 5. Core antigen levels were significantly

higher in LDLT patients on days 3 and 5, although they were similar before

LT (P = NS). Alanine aminotransferase (ALT) values were higher among LDLT

patients from 8 to 14 days and from 4 to 24 months. Two-year graft and

patient survival were 73% for LDLT patients and 80% for DDLT patients (P =

NS). In conclusion, viral load rose more rapidly in LD recipients and

reached higher levels shortly after surgery. Greater ALT elevations were

evident in the LDLT group, but survival rates were similar. The trend toward

a greater initial viral load decrease in patients with LD grafts and the

significantly sharper increase suggest that the liver plays a predominant

role in both HCV clearance and replication. (HEPATOLOGY 2005;42:1420-1428.).

PMID: 16317672

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[Guest guest]

Hepatology. 2005 Dec;42(6):1420-8.

Accelerated hepatitis C virus kinetics but similar survival rates in

recipients of liver grafts from living versus deceased donors.

Schiano TD, Gutierrez JA, Walewski JL, Fiel MI, Cheng B, Bodenheimer H Jr,

Thung SN, Chung RT, Schwartz ME, Bodian C, Branch AD.

The Recanati/ Transplantation Institute, The Mount Sinai Hospital, New

York, NY.

This study tested the hypothesis that hepatitis C virus (HCV) RNA and core

antigen levels rise more rapidly after liver transplantation (LT) in

recipients of grafts from living donors (LD) versus deceased donors (DD).

Eleven consecutive LD and 15 DD recipients were followed prospectively.

Before LT, median HCV RNA levels were similar: 5.42 (LDLT) and 5.07 (DDLT)

log(10) IU/mL (P = NS). During the first 7 hours after LT a trend toward a

greater HCV RNA decrease in LDLT patients was seen, although they received

fewer blood replacement products during surgery. HCV RNA levels rose more

rapidly in LDLT patients between days 1 and 3 (P = .0059) and were higher in

this group on days 2, 3, 4, and 5. Core antigen levels were significantly

higher in LDLT patients on days 3 and 5, although they were similar before

LT (P = NS). Alanine aminotransferase (ALT) values were higher among LDLT

patients from 8 to 14 days and from 4 to 24 months. Two-year graft and

patient survival were 73% for LDLT patients and 80% for DDLT patients (P =

NS). In conclusion, viral load rose more rapidly in LD recipients and

reached higher levels shortly after surgery. Greater ALT elevations were

evident in the LDLT group, but survival rates were similar. The trend toward

a greater initial viral load decrease in patients with LD grafts and the

significantly sharper increase suggest that the liver plays a predominant

role in both HCV clearance and replication. (HEPATOLOGY 2005;42:1420-1428.).

PMID: 16317672

_________________________________________________________________

Express yourself instantly with MSN Messenger! Download today - it's FREE!

http://messenger.msn.click-url.com/go/onm00200471ave/direct/01/