Re: Antidepressant-Associated Conversion to Mania

[Guest guest]

In a message dated 9/2/04 11:37:52 AM US Eastern Standard Time,

defonz3@... writes:

> yes...i read that as 10% in 10 - 14 year olds and just over 4% in 15 - 29

> yea

> olds.

>

> Cassandra i finally heard you on the Annie Armen show. WAY TO GO! was a

> fabulously informative program that was!! Kudos!

>

>

>

>

>

> >

> >

> > I need some help with this one... Is this saying that there is a 10%

> chance

> > that kids ages 10-14 will become manic after being given an

> > antidepressant???

> >

> > DON'T YOU THINK THIS IS SOMETHING EVERYONE SHOULD KNOW?!!!!

> >

> > http://www.medscape.com/viewarticle/487973?src=search

> >

> > Age Is an Effect Modifier on Antidepressant-Associated Conversion to

> Mania

> >

>

Also the 10 year old and how much he was being given.

It must increase with the dossage as well too don't you think?

10 mg to 90mg in a matter of a couple weeks.

Annie is the greatest! Her show is a much needed influence in our lives and

life

Marhoefer

The Defense Foundation for children USA

In a caring heart it is the silent cries that are heard the loudest~DM2003

<A

HREF= " www.defensefoundationforchildren.com " >www.defensefoundationforchildren.com\

</A>

~Changing The Destiny Of A Child ~

Investigative Journalism- Defense Resources

-Support Our Truth In Media Campaign-

[Guest guest]

In a message dated 9/2/04 11:37:52 AM US Eastern Standard Time,

defonz3@... writes:

> yes...i read that as 10% in 10 - 14 year olds and just over 4% in 15 - 29

> yea

> olds.

>

> Cassandra i finally heard you on the Annie Armen show. WAY TO GO! was a

> fabulously informative program that was!! Kudos!

>

>

>

>

>

> >

> >

> > I need some help with this one... Is this saying that there is a 10%

> chance

> > that kids ages 10-14 will become manic after being given an

> > antidepressant???

> >

> > DON'T YOU THINK THIS IS SOMETHING EVERYONE SHOULD KNOW?!!!!

> >

> > http://www.medscape.com/viewarticle/487973?src=search

> >

> > Age Is an Effect Modifier on Antidepressant-Associated Conversion to

> Mania

> >

>

Also the 10 year old and how much he was being given.

It must increase with the dossage as well too don't you think?

10 mg to 90mg in a matter of a couple weeks.

Annie is the greatest! Her show is a much needed influence in our lives and

life

Marhoefer

The Defense Foundation for children USA

In a caring heart it is the silent cries that are heard the loudest~DM2003

<A

HREF= " www.defensefoundationforchildren.com " >www.defensefoundationforchildren.com\

</A>

~Changing The Destiny Of A Child ~

Investigative Journalism- Defense Resources

-Support Our Truth In Media Campaign-

[Guest guest]

yes...i read that as 10% in 10 - 14 year olds and just over 4% in 15 - 29 yea

olds.

Cassandra i finally heard you on the Annie Armen show. WAY TO GO! was a

fabulously informative program that was!! Kudos!

>

>

> I need some help with this one... Is this saying that there is a 10% chance

> that kids ages 10-14 will become manic after being given an

> antidepressant???

>

> DON'T YOU THINK THIS IS SOMETHING EVERYONE SHOULD KNOW?!!!!

>

> http://www.medscape.com/viewarticle/487973?src=search

>

> Age Is an Effect Modifier on Antidepressant-Associated Conversion to

Mania

>

>

> NEW YORK (Reuters Health) Aug 20 - Patient age is an effect modifier on

> antidepressant-induced manic conversion, according to study in the August

> issue of the Archives of Pediatric and Adolescent Medicine.

> " Antidepressant drug therapy can precipitate mania in vulnerable

> individuals, but little is known about the effects of age on this

> phenomenon, " write Dr. Andres , of Yale University School of

Medicine,

> New Haven, Connecticut, and colleagues.

>

> The researchers used an administrative national database of linked

> outpatient and pharmacy claims to assess the risk of conversion to mania by

> antidepressant class and patient age in those between the ages of 5 and 29

> years. They evaluated the proportion and cumulative hazard of manic

> conversion for children, adolescents, and young adults with an anxiety or

> nonbipolar mood disorder. They defined manic conversion as a new

diagnosis

> of bipolar illness.

> Of 87,920 patients included in the sample, 4786 (5.4%) converted to mania

> over a median follow-up of 41 weeks. Antidepressant medication was used

by a

> total of 32,864 patients (37.4%). Multivariate analysis demonstrated that an

> increased risk of conversion to mania was associated with antidepressant

> exposure versus no antidepressant exposure (hazard ratios: 3.9 for tricyclic

> antidepressants, 3.8 for " other " antidepressants, and 2.1 for selective

> serotonin reuptake inhibitors).

>

> Antidepressant-age interactions showed significant inverse age effects for

> selective serotonin reuptake inhibitors and other antidepressants (p < 0.001

> for both). No such effects were found for tricyclic antidepressants.

> " The hazard was highest for the peripubertal group of 10- to 14-year-old

> patients, such that treating as few as 10 children with an antidepressant

> agent could result in at least 1 conversion event, compared with 23 among

> 15- to 29-year-olds, " Dr. and colleagues write.

>

> " Our findings must be considered preliminary associations and must not be

> taken to equate direct causality, especially in light of the limitations we

> outlined earlier, " the authors write.

>

> Still, they suggest that " caution and restraint may be especially pertinent

> wen treating children whose symptoms are not a major source of

impairment,

> those with a strong family history of bipolar disorder, or those who have

> not yet tried (and failed) psychotherapeutic interventions of proven

> efficacy. "

> Arch Pediatr Adolesc Med 2004;158:773-780.

[Guest guest]

yes...i read that as 10% in 10 - 14 year olds and just over 4% in 15 - 29 yea

olds.

Cassandra i finally heard you on the Annie Armen show. WAY TO GO! was a

fabulously informative program that was!! Kudos!

>

>

> I need some help with this one... Is this saying that there is a 10% chance

> that kids ages 10-14 will become manic after being given an

> antidepressant???

>

> DON'T YOU THINK THIS IS SOMETHING EVERYONE SHOULD KNOW?!!!!

>

> http://www.medscape.com/viewarticle/487973?src=search

>

> Age Is an Effect Modifier on Antidepressant-Associated Conversion to

Mania

>

>

> NEW YORK (Reuters Health) Aug 20 - Patient age is an effect modifier on

> antidepressant-induced manic conversion, according to study in the August

> issue of the Archives of Pediatric and Adolescent Medicine.

> " Antidepressant drug therapy can precipitate mania in vulnerable

> individuals, but little is known about the effects of age on this

> phenomenon, " write Dr. Andres , of Yale University School of

Medicine,

> New Haven, Connecticut, and colleagues.

>

> The researchers used an administrative national database of linked

> outpatient and pharmacy claims to assess the risk of conversion to mania by

> antidepressant class and patient age in those between the ages of 5 and 29

> years. They evaluated the proportion and cumulative hazard of manic

> conversion for children, adolescents, and young adults with an anxiety or

> nonbipolar mood disorder. They defined manic conversion as a new

diagnosis

> of bipolar illness.

> Of 87,920 patients included in the sample, 4786 (5.4%) converted to mania

> over a median follow-up of 41 weeks. Antidepressant medication was used

by a

> total of 32,864 patients (37.4%). Multivariate analysis demonstrated that an

> increased risk of conversion to mania was associated with antidepressant

> exposure versus no antidepressant exposure (hazard ratios: 3.9 for tricyclic

> antidepressants, 3.8 for " other " antidepressants, and 2.1 for selective

> serotonin reuptake inhibitors).

>

> Antidepressant-age interactions showed significant inverse age effects for

> selective serotonin reuptake inhibitors and other antidepressants (p < 0.001

> for both). No such effects were found for tricyclic antidepressants.

> " The hazard was highest for the peripubertal group of 10- to 14-year-old

> patients, such that treating as few as 10 children with an antidepressant

> agent could result in at least 1 conversion event, compared with 23 among

> 15- to 29-year-olds, " Dr. and colleagues write.

>

> " Our findings must be considered preliminary associations and must not be

> taken to equate direct causality, especially in light of the limitations we

> outlined earlier, " the authors write.

>

> Still, they suggest that " caution and restraint may be especially pertinent

> wen treating children whose symptoms are not a major source of

impairment,

> those with a strong family history of bipolar disorder, or those who have

> not yet tried (and failed) psychotherapeutic interventions of proven

> efficacy. "

> Arch Pediatr Adolesc Med 2004;158:773-780.

[Guest guest]

yes...i read that as 10% in 10 - 14 year olds and just over 4% in 15 - 29 yea

olds.

Cassandra i finally heard you on the Annie Armen show. WAY TO GO! was a

fabulously informative program that was!! Kudos!

>

>

> I need some help with this one... Is this saying that there is a 10% chance

> that kids ages 10-14 will become manic after being given an

> antidepressant???

>

> DON'T YOU THINK THIS IS SOMETHING EVERYONE SHOULD KNOW?!!!!

>

> http://www.medscape.com/viewarticle/487973?src=search

>

> Age Is an Effect Modifier on Antidepressant-Associated Conversion to

Mania

>

>

> NEW YORK (Reuters Health) Aug 20 - Patient age is an effect modifier on

> antidepressant-induced manic conversion, according to study in the August

> issue of the Archives of Pediatric and Adolescent Medicine.

> " Antidepressant drug therapy can precipitate mania in vulnerable

> individuals, but little is known about the effects of age on this

> phenomenon, " write Dr. Andres , of Yale University School of

Medicine,

> New Haven, Connecticut, and colleagues.

>

> The researchers used an administrative national database of linked

> outpatient and pharmacy claims to assess the risk of conversion to mania by

> antidepressant class and patient age in those between the ages of 5 and 29

> years. They evaluated the proportion and cumulative hazard of manic

> conversion for children, adolescents, and young adults with an anxiety or

> nonbipolar mood disorder. They defined manic conversion as a new

diagnosis

> of bipolar illness.

> Of 87,920 patients included in the sample, 4786 (5.4%) converted to mania

> over a median follow-up of 41 weeks. Antidepressant medication was used

by a

> total of 32,864 patients (37.4%). Multivariate analysis demonstrated that an

> increased risk of conversion to mania was associated with antidepressant

> exposure versus no antidepressant exposure (hazard ratios: 3.9 for tricyclic

> antidepressants, 3.8 for " other " antidepressants, and 2.1 for selective

> serotonin reuptake inhibitors).

>

> Antidepressant-age interactions showed significant inverse age effects for

> selective serotonin reuptake inhibitors and other antidepressants (p < 0.001

> for both). No such effects were found for tricyclic antidepressants.

> " The hazard was highest for the peripubertal group of 10- to 14-year-old

> patients, such that treating as few as 10 children with an antidepressant

> agent could result in at least 1 conversion event, compared with 23 among

> 15- to 29-year-olds, " Dr. and colleagues write.

>

> " Our findings must be considered preliminary associations and must not be

> taken to equate direct causality, especially in light of the limitations we

> outlined earlier, " the authors write.

>

> Still, they suggest that " caution and restraint may be especially pertinent

> wen treating children whose symptoms are not a major source of

impairment,

> those with a strong family history of bipolar disorder, or those who have

> not yet tried (and failed) psychotherapeutic interventions of proven

> efficacy. "

> Arch Pediatr Adolesc Med 2004;158:773-780.

[Guest guest]

yes...i read that as 10% in 10 - 14 year olds and just over 4% in 15 - 29 yea

olds.

Cassandra i finally heard you on the Annie Armen show. WAY TO GO! was a

fabulously informative program that was!! Kudos!

>

>

> I need some help with this one... Is this saying that there is a 10% chance

> that kids ages 10-14 will become manic after being given an

> antidepressant???

>

> DON'T YOU THINK THIS IS SOMETHING EVERYONE SHOULD KNOW?!!!!

>

> http://www.medscape.com/viewarticle/487973?src=search

>

> Age Is an Effect Modifier on Antidepressant-Associated Conversion to

Mania

>

>

> NEW YORK (Reuters Health) Aug 20 - Patient age is an effect modifier on

> antidepressant-induced manic conversion, according to study in the August

> issue of the Archives of Pediatric and Adolescent Medicine.

> " Antidepressant drug therapy can precipitate mania in vulnerable

> individuals, but little is known about the effects of age on this

> phenomenon, " write Dr. Andres , of Yale University School of

Medicine,

> New Haven, Connecticut, and colleagues.

>

> The researchers used an administrative national database of linked

> outpatient and pharmacy claims to assess the risk of conversion to mania by

> antidepressant class and patient age in those between the ages of 5 and 29

> years. They evaluated the proportion and cumulative hazard of manic

> conversion for children, adolescents, and young adults with an anxiety or

> nonbipolar mood disorder. They defined manic conversion as a new

diagnosis

> of bipolar illness.

> Of 87,920 patients included in the sample, 4786 (5.4%) converted to mania

> over a median follow-up of 41 weeks. Antidepressant medication was used

by a

> total of 32,864 patients (37.4%). Multivariate analysis demonstrated that an

> increased risk of conversion to mania was associated with antidepressant

> exposure versus no antidepressant exposure (hazard ratios: 3.9 for tricyclic

> antidepressants, 3.8 for " other " antidepressants, and 2.1 for selective

> serotonin reuptake inhibitors).

>

> Antidepressant-age interactions showed significant inverse age effects for

> selective serotonin reuptake inhibitors and other antidepressants (p < 0.001

> for both). No such effects were found for tricyclic antidepressants.

> " The hazard was highest for the peripubertal group of 10- to 14-year-old

> patients, such that treating as few as 10 children with an antidepressant

> agent could result in at least 1 conversion event, compared with 23 among

> 15- to 29-year-olds, " Dr. and colleagues write.

>

> " Our findings must be considered preliminary associations and must not be

> taken to equate direct causality, especially in light of the limitations we

> outlined earlier, " the authors write.

>

> Still, they suggest that " caution and restraint may be especially pertinent

> wen treating children whose symptoms are not a major source of

impairment,

> those with a strong family history of bipolar disorder, or those who have

> not yet tried (and failed) psychotherapeutic interventions of proven

> efficacy. "

> Arch Pediatr Adolesc Med 2004;158:773-780.

[Guest guest]

I swear the only difference between the children and the adults is

that adults have practiced restraining themselves while children haven't.

Re: Antidepressant-Associated Conversion to Mania

> yes...i read that as 10% in 10 - 14 year olds and just over 4% in 15 - 29

yea

> olds.

>

> Cassandra i finally heard you on the Annie Armen show. WAY TO GO! was a

> fabulously informative program that was!! Kudos!

>

>

>

>

>

> >

> >

> > I need some help with this one... Is this saying that there is a 10%

chance

> > that kids ages 10-14 will become manic after being given an

> > antidepressant???

> >

> > DON'T YOU THINK THIS IS SOMETHING EVERYONE SHOULD KNOW?!!!!

> >

> > http://www.medscape.com/viewarticle/487973?src=search

> >

> > Age Is an Effect Modifier on Antidepressant-Associated Conversion to

> Mania

> >

> >

> > NEW YORK (Reuters Health) Aug 20 - Patient age is an effect modifier on

> > antidepressant-induced manic conversion, according to study in the

August

> > issue of the Archives of Pediatric and Adolescent Medicine.

> > " Antidepressant drug therapy can precipitate mania in vulnerable

> > individuals, but little is known about the effects of age on this

> > phenomenon, " write Dr. Andres , of Yale University School of

> Medicine,

> > New Haven, Connecticut, and colleagues.

> >

> > The researchers used an administrative national database of linked

> > outpatient and pharmacy claims to assess the risk of conversion to mania

by

> > antidepressant class and patient age in those between the ages of 5 and

29

> > years. They evaluated the proportion and cumulative hazard of manic

> > conversion for children, adolescents, and young adults with an anxiety

or

> > nonbipolar mood disorder. They defined manic conversion as a new

> diagnosis

> > of bipolar illness.

> > Of 87,920 patients included in the sample, 4786 (5.4%) converted to

mania

> > over a median follow-up of 41 weeks. Antidepressant medication was used

> by a

> > total of 32,864 patients (37.4%). Multivariate analysis demonstrated

that an

> > increased risk of conversion to mania was associated with antidepressant

> > exposure versus no antidepressant exposure (hazard ratios: 3.9 for

tricyclic

> > antidepressants, 3.8 for " other " antidepressants, and 2.1 for selective

> > serotonin reuptake inhibitors).

> >

> > Antidepressant-age interactions showed significant inverse age effects

for

> > selective serotonin reuptake inhibitors and other antidepressants (p <

0.001

> > for both). No such effects were found for tricyclic antidepressants.

> > " The hazard was highest for the peripubertal group of 10- to 14-year-old

> > patients, such that treating as few as 10 children with an

antidepressant

> > agent could result in at least 1 conversion event, compared with 23

among

> > 15- to 29-year-olds, " Dr. and colleagues write.

> >

> > " Our findings must be considered preliminary associations and must not

be

> > taken to equate direct causality, especially in light of the limitations

we

> > outlined earlier, " the authors write.

> >

> > Still, they suggest that " caution and restraint may be especially

pertinent

> > wen treating children whose symptoms are not a major source of

> impairment,

> > those with a strong family history of bipolar disorder, or those who

have

> > not yet tried (and failed) psychotherapeutic interventions of proven

> > efficacy. "

> > Arch Pediatr Adolesc Med 2004;158:773-780.

>

>

>

>

>

>

[Guest guest]

I swear the only difference between the children and the adults is

that adults have practiced restraining themselves while children haven't.

Re: Antidepressant-Associated Conversion to Mania

> yes...i read that as 10% in 10 - 14 year olds and just over 4% in 15 - 29

yea

> olds.

>

> Cassandra i finally heard you on the Annie Armen show. WAY TO GO! was a

> fabulously informative program that was!! Kudos!

>

>

>

>

>

> >

> >

> > I need some help with this one... Is this saying that there is a 10%

chance

> > that kids ages 10-14 will become manic after being given an

> > antidepressant???

> >

> > DON'T YOU THINK THIS IS SOMETHING EVERYONE SHOULD KNOW?!!!!

> >

> > http://www.medscape.com/viewarticle/487973?src=search

> >

> > Age Is an Effect Modifier on Antidepressant-Associated Conversion to

> Mania

> >

> >

> > NEW YORK (Reuters Health) Aug 20 - Patient age is an effect modifier on

> > antidepressant-induced manic conversion, according to study in the

August

> > issue of the Archives of Pediatric and Adolescent Medicine.

> > " Antidepressant drug therapy can precipitate mania in vulnerable

> > individuals, but little is known about the effects of age on this

> > phenomenon, " write Dr. Andres , of Yale University School of

> Medicine,

> > New Haven, Connecticut, and colleagues.

> >

> > The researchers used an administrative national database of linked

> > outpatient and pharmacy claims to assess the risk of conversion to mania

by

> > antidepressant class and patient age in those between the ages of 5 and

29

> > years. They evaluated the proportion and cumulative hazard of manic

> > conversion for children, adolescents, and young adults with an anxiety

or

> > nonbipolar mood disorder. They defined manic conversion as a new

> diagnosis

> > of bipolar illness.

> > Of 87,920 patients included in the sample, 4786 (5.4%) converted to

mania

> > over a median follow-up of 41 weeks. Antidepressant medication was used

> by a

> > total of 32,864 patients (37.4%). Multivariate analysis demonstrated

that an

> > increased risk of conversion to mania was associated with antidepressant

> > exposure versus no antidepressant exposure (hazard ratios: 3.9 for

tricyclic

> > antidepressants, 3.8 for " other " antidepressants, and 2.1 for selective

> > serotonin reuptake inhibitors).

> >

> > Antidepressant-age interactions showed significant inverse age effects

for

> > selective serotonin reuptake inhibitors and other antidepressants (p <

0.001

> > for both). No such effects were found for tricyclic antidepressants.

> > " The hazard was highest for the peripubertal group of 10- to 14-year-old

> > patients, such that treating as few as 10 children with an

antidepressant

> > agent could result in at least 1 conversion event, compared with 23

among

> > 15- to 29-year-olds, " Dr. and colleagues write.

> >

> > " Our findings must be considered preliminary associations and must not

be

> > taken to equate direct causality, especially in light of the limitations

we

> > outlined earlier, " the authors write.

> >

> > Still, they suggest that " caution and restraint may be especially

pertinent

> > wen treating children whose symptoms are not a major source of

> impairment,

> > those with a strong family history of bipolar disorder, or those who

have

> > not yet tried (and failed) psychotherapeutic interventions of proven

> > efficacy. "

> > Arch Pediatr Adolesc Med 2004;158:773-780.

>

>

>

>

>

>

[Guest guest]

> My son NEVER had a manic episode until he was put

> on Paxil and Concerta. This was less than two week

> after he attempted suicide on Prozac. We have a

> doctors record describing the incident as a Grandiose

> Manic Episode. After this the doctor then added

> Seroquil and Trilipal.

Sounds like this Pennsylvania-style drug cocktail disaster may

have been the result of doctor/s not checking interactions

between drugs.

[Guest guest]

> My son NEVER had a manic episode until he was put

> on Paxil and Concerta. This was less than two week

> after he attempted suicide on Prozac. We have a

> doctors record describing the incident as a Grandiose

> Manic Episode. After this the doctor then added

> Seroquil and Trilipal.

Sounds like this Pennsylvania-style drug cocktail disaster may

have been the result of doctor/s not checking interactions

between drugs.