Whole-Body Insulin Sensitivity Index Is a Highly Specific Predictive Marker for Virological Response to Peginterferon Plus Ribavirin Therapy in Chronic Hepatitis C Patients with Genotype 1b and High Viral Load

[Guest guest]

Dig Dis Sci. 2009 Jan 30. [Epub ahead of print]

Whole-Body Insulin Sensitivity Index Is a Highly Specific Predictive Marker for

Virological Response to Peginterferon Plus Ribavirin Therapy in Chronic

Hepatitis C Patients with Genotype 1b and High Viral Load.

Mizuta T, Kawaguchi Y, Eguchi Y, Takahashi H, Ario K, Akiyama T, Oza N, Otsuka

T, Kuwashiro T, Yoshimura T, Hisatomi A, Ozaki I.

Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga,

Japan, mizutat@....

Insulin resistance is a candidate predictive factor for virological response to

peginterferon plus ribavirin (PEG/RBV) therapy in chronic hepatitis C patients.

We examined whether indices of insulin resistance could serve as a predictor of

sustained virological response (SVR). Fifty-one patients with genotype 1b and

high viral load who received PEG/RBV therapy for 48 weeks were included.

Homeostasis model assessment of insulin resistance (HOMA-IR) and whole-body

insulin sensitivity index (WBISI) calculated from the 75-g oral glucose

tolerance test and serum levels of soluble tumor necrosis factor receptor 2

(sTFNR2) were evaluated before therapy. Patients who achieved SVR had

significantly lower HOMA-IR and sTNFR2 levels and a higher WBISI compared with

non-SVR patients. The positive predictive value for SVR was 0.653 for a HOMA-IR

of

[Guest guest]

Dig Dis Sci. 2009 Jan 30. [Epub ahead of print]

Whole-Body Insulin Sensitivity Index Is a Highly Specific Predictive Marker for

Virological Response to Peginterferon Plus Ribavirin Therapy in Chronic

Hepatitis C Patients with Genotype 1b and High Viral Load.

Mizuta T, Kawaguchi Y, Eguchi Y, Takahashi H, Ario K, Akiyama T, Oza N, Otsuka

T, Kuwashiro T, Yoshimura T, Hisatomi A, Ozaki I.

Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga,

Japan, mizutat@....

Insulin resistance is a candidate predictive factor for virological response to

peginterferon plus ribavirin (PEG/RBV) therapy in chronic hepatitis C patients.

We examined whether indices of insulin resistance could serve as a predictor of

sustained virological response (SVR). Fifty-one patients with genotype 1b and

high viral load who received PEG/RBV therapy for 48 weeks were included.

Homeostasis model assessment of insulin resistance (HOMA-IR) and whole-body

insulin sensitivity index (WBISI) calculated from the 75-g oral glucose

tolerance test and serum levels of soluble tumor necrosis factor receptor 2

(sTFNR2) were evaluated before therapy. Patients who achieved SVR had

significantly lower HOMA-IR and sTNFR2 levels and a higher WBISI compared with

non-SVR patients. The positive predictive value for SVR was 0.653 for a HOMA-IR

of