Interaction of hepatitis B virus core protein with human GIPC1

[Guest guest]

Arch Virol. 2009 Nov 29. [Epub ahead of print]

Interaction of hepatitis B virus core protein with human GIPC1.

Razanskas R, Sasnauskas K.

Institute of Biotechnology, Graiciuno 8, 02241, Vilnius, Lithuania,

raimis@....

Up to now, little is known about hepatitis B virus core protein (HBc)

interactions with host-cell proteins, although such interactions might be

essential for virus propagation and pathogenicity. In this work, a human liver

cDNA library was screened for proteins interacting with HBc. Among several

HBc-interacting partners selected, it interacted most strongly with the human

protein GIPC1. A common protein interaction domain, PDZ, was identified as the

region that is sufficient for the interaction with HBc. The core protein has a

putative C-terminal PDZ-interacting motif, and this sequence proved to be

important for the interaction with GIPC1.

PMID: 20091192 [PubMed - as supplied by publisher]

[Guest guest]

Arch Virol. 2009 Nov 29. [Epub ahead of print]

Interaction of hepatitis B virus core protein with human GIPC1.

Razanskas R, Sasnauskas K.

Institute of Biotechnology, Graiciuno 8, 02241, Vilnius, Lithuania,

raimis@....

Up to now, little is known about hepatitis B virus core protein (HBc)

interactions with host-cell proteins, although such interactions might be

essential for virus propagation and pathogenicity. In this work, a human liver

cDNA library was screened for proteins interacting with HBc. Among several

HBc-interacting partners selected, it interacted most strongly with the human

protein GIPC1. A common protein interaction domain, PDZ, was identified as the

region that is sufficient for the interaction with HBc. The core protein has a

putative C-terminal PDZ-interacting motif, and this sequence proved to be

important for the interaction with GIPC1.

PMID: 20091192 [PubMed - as supplied by publisher]