Tobacco and other factors have a negative impact on quality of life in hepatitis C patients

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2010.01361.x/abstract

Tobacco and other factors have a negative impact on quality of life in hepatitis

C patients

D. Yamini, B. Basseri, G. M. Chee, A. Arakelyan, P. Enayati, T. T. Tran, F.

PoordadArticle first published online: 15 AUG 2010

DOI: 10.1111/j.1365-2893.2010.01361.x

© 2010 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Early View (Articles online in advance of print)

Summary.  Hepatitis C virus (HCV) is known to adversely affect general,

social, emotional and mental health domains. This study was designed to identify

variables that may be associated with these measurable outcomes. We conducted a

cross-sectional retrospective review of demographic and clinical data from 800

patients with HCV evaluated between January 1998 and November 2007. Data were

collected using a standardized questionnaire filled out by the patients at the

first encounter. Variables evaluated included fibrosis stages (i.e. FS0/1/2 vs

FS3/4), demographics, comorbid health conditions, tobacco and alcohol use,

high-risk social behaviours and laboratory data. Variables assessed were

depression, fatigue, problems sleeping and loss of interest in sex. Statistical

analysis was performed using univariate and multivariate logistic regression.

Depression (29.3%) in our HCV study population was associated with female

gender, tobacco use, hyperlipidemia, history of heavy alcohol use and

intravenous drug use. Fatigue (44.6%) was associated with end-stage renal

disease, past and current tobacco use and current alcohol use. Difficulty

sleeping (13.8%) was associated with past and current tobacco use, current

alcohol use and diabetes. Loss of interest in sex (7.7%) was associated with

current tobacco use, multiple risk factors for HCV and age at time of

evaluation. Fibrosis stage (FS) also had a significant positive association with

alcohol use (OR 2.61; P = 0.003) and tobacco use (OR 2.00; P = 0.002). Smoking

and alcohol use have a significant negative impact on the presence of

depression, fatigue, difficulty sleeping and loss of interest in sex in HCV

patients. Practitioners should be aware of these associations, particularly

tobacco use, which significantly and negatively impacted every variable

evaluated.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2010.01361.x/abstract

Tobacco and other factors have a negative impact on quality of life in hepatitis

C patients

D. Yamini, B. Basseri, G. M. Chee, A. Arakelyan, P. Enayati, T. T. Tran, F.

PoordadArticle first published online: 15 AUG 2010

DOI: 10.1111/j.1365-2893.2010.01361.x

© 2010 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Early View (Articles online in advance of print)

Summary.  Hepatitis C virus (HCV) is known to adversely affect general,

social, emotional and mental health domains. This study was designed to identify

variables that may be associated with these measurable outcomes. We conducted a

cross-sectional retrospective review of demographic and clinical data from 800

patients with HCV evaluated between January 1998 and November 2007. Data were

collected using a standardized questionnaire filled out by the patients at the

first encounter. Variables evaluated included fibrosis stages (i.e. FS0/1/2 vs

FS3/4), demographics, comorbid health conditions, tobacco and alcohol use,

high-risk social behaviours and laboratory data. Variables assessed were

depression, fatigue, problems sleeping and loss of interest in sex. Statistical

analysis was performed using univariate and multivariate logistic regression.

Depression (29.3%) in our HCV study population was associated with female

gender, tobacco use, hyperlipidemia, history of heavy alcohol use and

intravenous drug use. Fatigue (44.6%) was associated with end-stage renal

disease, past and current tobacco use and current alcohol use. Difficulty

sleeping (13.8%) was associated with past and current tobacco use, current

alcohol use and diabetes. Loss of interest in sex (7.7%) was associated with

current tobacco use, multiple risk factors for HCV and age at time of

evaluation. Fibrosis stage (FS) also had a significant positive association with

alcohol use (OR 2.61; P = 0.003) and tobacco use (OR 2.00; P = 0.002). Smoking

and alcohol use have a significant negative impact on the presence of

depression, fatigue, difficulty sleeping and loss of interest in sex in HCV

patients. Practitioners should be aware of these associations, particularly

tobacco use, which significantly and negatively impacted every variable

evaluated.