Mortality in Siblings of Patients Coinfected with HIV and Hepatitis C Virus

[Guest guest]

J Infect Dis. 2007 Jan 15;195(2):230-5. Epub 2006 Dec 11.

Mortality in Siblings of Patients Coinfected with HIV and Hepatitis C Virus.

Hansen AB, Gerstoft J, Kronborg G, Pedersen C, Sorensen HT, Obel N.

Department of Infectious Diseases, Odense University Hospital, DK-5000

Odense C, Denmark. ann-brit.eg.hansen@....

Background. Coinfection with hepatitis C virus (HCV) is a poor prognostic

factor for human immunodeficiency virus (HIV)-infected patients. We examined

whether the increased mortality in these patients is partly explained by a

familial excess risk of death.Methods. Danish HIV-infected patients who had

had at least 1 HCV test were included (n=3531). In addition, 336,652

population control subjects matched for sex, age, and residency were

identified from the Danish Civil Registration System. For both HIV-infected

patients and population control subjects, we identified all siblings born

after 1951, with dates of death or emigration. Siblings of HIV-infected

patients were classified according to the patients' HCV serostatus. Survival

after age 20 years was compared among the groups of siblings.Results. We

identified 437 siblings of HIV/HCV-coinfected patients, 1856 siblings of

HIV-monoinfected patients, and 285,509 siblings of population control

subjects. Mortality was substantially higher in siblings of

HIV/HCV-coinfected patients than in either siblings of HIV-monoinfected

patients (mortality rate ratio [MRR], 2.97 [95% confidence interval {CI},

1.98-4.45]) or siblings of control subjects (MRR, 4.23 [95% CI, 3.09-5.79]).

Siblings of HIV-monoinfected patients had slightly higher mortality (MRR,

1.43 [95% CI, 1.10-1.85]) than siblings of control subjects.Conclusions. HCV

infection is a marker of familial factors that affect the survival of

HIV-infected patients independently of the pathogenicity of HCV.

PMID: 17191168 [PubMed - in process]

_________________________________________________________________

Find sales, coupons, and free shipping, all in one place!  MSN Shopping

Sales & Deals

http://shopping.msn.com/content/shp/?ctid=198,ptnrid=176,ptnrdata=200639

[Guest guest]

J Infect Dis. 2007 Jan 15;195(2):230-5. Epub 2006 Dec 11.

Mortality in Siblings of Patients Coinfected with HIV and Hepatitis C Virus.

Hansen AB, Gerstoft J, Kronborg G, Pedersen C, Sorensen HT, Obel N.

Department of Infectious Diseases, Odense University Hospital, DK-5000

Odense C, Denmark. ann-brit.eg.hansen@....

Background. Coinfection with hepatitis C virus (HCV) is a poor prognostic

factor for human immunodeficiency virus (HIV)-infected patients. We examined

whether the increased mortality in these patients is partly explained by a

familial excess risk of death.Methods. Danish HIV-infected patients who had

had at least 1 HCV test were included (n=3531). In addition, 336,652

population control subjects matched for sex, age, and residency were

identified from the Danish Civil Registration System. For both HIV-infected

patients and population control subjects, we identified all siblings born

after 1951, with dates of death or emigration. Siblings of HIV-infected

patients were classified according to the patients' HCV serostatus. Survival

after age 20 years was compared among the groups of siblings.Results. We

identified 437 siblings of HIV/HCV-coinfected patients, 1856 siblings of

HIV-monoinfected patients, and 285,509 siblings of population control

subjects. Mortality was substantially higher in siblings of

HIV/HCV-coinfected patients than in either siblings of HIV-monoinfected

patients (mortality rate ratio [MRR], 2.97 [95% confidence interval {CI},

1.98-4.45]) or siblings of control subjects (MRR, 4.23 [95% CI, 3.09-5.79]).

Siblings of HIV-monoinfected patients had slightly higher mortality (MRR,

1.43 [95% CI, 1.10-1.85]) than siblings of control subjects.Conclusions. HCV

infection is a marker of familial factors that affect the survival of

HIV-infected patients independently of the pathogenicity of HCV.

PMID: 17191168 [PubMed - in process]

_________________________________________________________________

Find sales, coupons, and free shipping, all in one place!  MSN Shopping

Sales & Deals

http://shopping.msn.com/content/shp/?ctid=198,ptnrid=176,ptnrdata=200639