Guest guest Posted January 1, 2007 Report Share Posted January 1, 2007 J Infect Dis. 2007 Jan 15;195(2):230-5. Epub 2006 Dec 11. Mortality in Siblings of Patients Coinfected with HIV and Hepatitis C Virus. Hansen AB, Gerstoft J, Kronborg G, Pedersen C, Sorensen HT, Obel N. Department of Infectious Diseases, Odense University Hospital, DK-5000 Odense C, Denmark. ann-brit.eg.hansen@.... Background. Coinfection with hepatitis C virus (HCV) is a poor prognostic factor for human immunodeficiency virus (HIV)-infected patients. We examined whether the increased mortality in these patients is partly explained by a familial excess risk of death.Methods. Danish HIV-infected patients who had had at least 1 HCV test were included (n=3531). In addition, 336,652 population control subjects matched for sex, age, and residency were identified from the Danish Civil Registration System. For both HIV-infected patients and population control subjects, we identified all siblings born after 1951, with dates of death or emigration. Siblings of HIV-infected patients were classified according to the patients' HCV serostatus. Survival after age 20 years was compared among the groups of siblings.Results. We identified 437 siblings of HIV/HCV-coinfected patients, 1856 siblings of HIV-monoinfected patients, and 285,509 siblings of population control subjects. Mortality was substantially higher in siblings of HIV/HCV-coinfected patients than in either siblings of HIV-monoinfected patients (mortality rate ratio [MRR], 2.97 [95% confidence interval {CI}, 1.98-4.45]) or siblings of control subjects (MRR, 4.23 [95% CI, 3.09-5.79]). Siblings of HIV-monoinfected patients had slightly higher mortality (MRR, 1.43 [95% CI, 1.10-1.85]) than siblings of control subjects.Conclusions. HCV infection is a marker of familial factors that affect the survival of HIV-infected patients independently of the pathogenicity of HCV. PMID: 17191168 [PubMed - in process] _________________________________________________________________ Find sales, coupons, and free shipping, all in one place! MSN Shopping Sales & Deals http://shopping.msn.com/content/shp/?ctid=198,ptnrid=176,ptnrdata=200639 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 1, 2007 Report Share Posted January 1, 2007 J Infect Dis. 2007 Jan 15;195(2):230-5. Epub 2006 Dec 11. Mortality in Siblings of Patients Coinfected with HIV and Hepatitis C Virus. Hansen AB, Gerstoft J, Kronborg G, Pedersen C, Sorensen HT, Obel N. Department of Infectious Diseases, Odense University Hospital, DK-5000 Odense C, Denmark. ann-brit.eg.hansen@.... Background. Coinfection with hepatitis C virus (HCV) is a poor prognostic factor for human immunodeficiency virus (HIV)-infected patients. We examined whether the increased mortality in these patients is partly explained by a familial excess risk of death.Methods. Danish HIV-infected patients who had had at least 1 HCV test were included (n=3531). In addition, 336,652 population control subjects matched for sex, age, and residency were identified from the Danish Civil Registration System. For both HIV-infected patients and population control subjects, we identified all siblings born after 1951, with dates of death or emigration. Siblings of HIV-infected patients were classified according to the patients' HCV serostatus. Survival after age 20 years was compared among the groups of siblings.Results. We identified 437 siblings of HIV/HCV-coinfected patients, 1856 siblings of HIV-monoinfected patients, and 285,509 siblings of population control subjects. Mortality was substantially higher in siblings of HIV/HCV-coinfected patients than in either siblings of HIV-monoinfected patients (mortality rate ratio [MRR], 2.97 [95% confidence interval {CI}, 1.98-4.45]) or siblings of control subjects (MRR, 4.23 [95% CI, 3.09-5.79]). Siblings of HIV-monoinfected patients had slightly higher mortality (MRR, 1.43 [95% CI, 1.10-1.85]) than siblings of control subjects.Conclusions. HCV infection is a marker of familial factors that affect the survival of HIV-infected patients independently of the pathogenicity of HCV. PMID: 17191168 [PubMed - in process] _________________________________________________________________ Find sales, coupons, and free shipping, all in one place! MSN Shopping Sales & Deals http://shopping.msn.com/content/shp/?ctid=198,ptnrid=176,ptnrdata=200639 Quote Link to comment Share on other sites More sharing options...
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