Antiviral Therapy in Acute Viral Hepatitis B: Why and When

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Antiviral therapy in acute viral hepatitis B: why and when

Acute viral hepatitis B is cleared in more than 95% of patients, while the

remainder ones may develop either chronic HBV infection or, rarely, fulminant

hepatitis.Therefore there are elderly patients with severe acute HBV hepatitis

caractherized by high serum bilirubin levels>15 mmole/dl, international

normalized ratio (INR) with value more than 1.6; these patients are

caractherized by a severe outcome of HBV infection.As known, outcome of

infection and the pathogenesis of liver diseases are determined by viral and

host factors, such as T reg lymphocytes.T regs may be associated with a negative

immune response such as an inhibition of gamma- IFN secretion.The impact of

viral load on antiviral T cell responses may play a critical role in thaese

patients, influencing disease persistence and immune response.Antiviral drugs

could be useful in these patients determing a possible down -regulation of T

regs.

Author: Giuseppe Morelli, Alessandro Perrella, Costanza Sbreglia, Pasquale

Bellopede, Monaco and Oreste Perrella

Credits/Source: Infectious Agents and Cancer 2009, 4:2

Published on: 2009-01-16

[Guest guest]

http://7thspace.com/headlines/302046/antiviral_therapy_in_acute_viral_hepatitis_\

b_why_and_when.html

Antiviral therapy in acute viral hepatitis B: why and when

Acute viral hepatitis B is cleared in more than 95% of patients, while the

remainder ones may develop either chronic HBV infection or, rarely, fulminant

hepatitis.Therefore there are elderly patients with severe acute HBV hepatitis

caractherized by high serum bilirubin levels>15 mmole/dl, international

normalized ratio (INR) with value more than 1.6; these patients are

caractherized by a severe outcome of HBV infection.As known, outcome of

infection and the pathogenesis of liver diseases are determined by viral and

host factors, such as T reg lymphocytes.T regs may be associated with a negative

immune response such as an inhibition of gamma- IFN secretion.The impact of

viral load on antiviral T cell responses may play a critical role in thaese

patients, influencing disease persistence and immune response.Antiviral drugs

could be useful in these patients determing a possible down -regulation of T

regs.

Author: Giuseppe Morelli, Alessandro Perrella, Costanza Sbreglia, Pasquale

Bellopede, Monaco and Oreste Perrella

Credits/Source: Infectious Agents and Cancer 2009, 4:2

Published on: 2009-01-16