Propensity Score Matching in the Evaluation of Drug Therapy Management Programs: An Illustrative Analysis of a Program for Patients With Hepatitis C Virus

[Guest guest]

http://journals.lww.com/qmhcjournal/Abstract/2010/01000/Propensity_Score_Matchin\

g_in_the_Evaluation_of.4.aspx

Quality Management in Health Care:

January/March 2010 - Volume 19 - Issue 1 - p 25–33

doi: 10.1097/QMH.0b013e3181ccbc7a

Article

Propensity Score Matching in the Evaluation of Drug Therapy Management Programs:

An Illustrative Analysis of a Program for Patients With Hepatitis C Virus

Hussein, Mohamed PhD; Benner, S. ScD; Lee, PhD; Sesti, Anne-Marie

PharmD; Battleman, S. MD; Brock-Wood, BS

Abstract

This retrospective cohort analysis demonstrates the application of propensity

score methods in the Be In Charge (BIC) program, a drug therapy management

program for patients with hepatitis C. Data were drawn from BIC participant

records and program utilization and from a longitudinal database of

administrative claims for pharmacy and medical services. Eligible patients must

have received peginterferon alfa-2b (PEG-IFN alfa-2b) and ribavirin, but

analyses evaluated only PEG-IFN alfa-2b use; BIC enrollees were matched with

patients not enrolled in BIC (controls). Adherence was measured on the basis of

the number of injections dispensed and the proportion of patients for whom an

average of at least 1 injection per week was dispensed during follow-up. BIC

subjects refilled 1.2 more injections than did controls (P < .001) within 12

weeks, 2.7 more (P < .001) within 24 weeks, and 6.7 more (P < .001) within 48

weeks. BIC enrollees were more likely than controls to refill the indicated dose

(1 injection per week) within 12 weeks (72% vs 64%, P < .001), 24 weeks (52% vs

41%, P < .001), and 48 weeks (22% vs 13%, P = .002) of initiation. These data

suggest that the BIC program may significantly improve adherence to PEG-IFN

alfa-2b.

©2010Lippincott & Wilkins, Inc.

[Guest guest]

http://journals.lww.com/qmhcjournal/Abstract/2010/01000/Propensity_Score_Matchin\

g_in_the_Evaluation_of.4.aspx

Quality Management in Health Care:

January/March 2010 - Volume 19 - Issue 1 - p 25–33

doi: 10.1097/QMH.0b013e3181ccbc7a

Article

Propensity Score Matching in the Evaluation of Drug Therapy Management Programs:

An Illustrative Analysis of a Program for Patients With Hepatitis C Virus

Hussein, Mohamed PhD; Benner, S. ScD; Lee, PhD; Sesti, Anne-Marie

PharmD; Battleman, S. MD; Brock-Wood, BS

Abstract

This retrospective cohort analysis demonstrates the application of propensity

score methods in the Be In Charge (BIC) program, a drug therapy management

program for patients with hepatitis C. Data were drawn from BIC participant

records and program utilization and from a longitudinal database of

administrative claims for pharmacy and medical services. Eligible patients must

have received peginterferon alfa-2b (PEG-IFN alfa-2b) and ribavirin, but

analyses evaluated only PEG-IFN alfa-2b use; BIC enrollees were matched with

patients not enrolled in BIC (controls). Adherence was measured on the basis of

the number of injections dispensed and the proportion of patients for whom an

average of at least 1 injection per week was dispensed during follow-up. BIC

subjects refilled 1.2 more injections than did controls (P < .001) within 12

weeks, 2.7 more (P < .001) within 24 weeks, and 6.7 more (P < .001) within 48

weeks. BIC enrollees were more likely than controls to refill the indicated dose

(1 injection per week) within 12 weeks (72% vs 64%, P < .001), 24 weeks (52% vs

41%, P < .001), and 48 weeks (22% vs 13%, P = .002) of initiation. These data

suggest that the BIC program may significantly improve adherence to PEG-IFN

alfa-2b.

©2010Lippincott & Wilkins, Inc.