Non-invasive assessment of liver fibrosis by stiffness measurement in patients with chronic hepatitis B

[Guest guest]

http://www3.interscience.wiley.com/journal/120751070/abstract

Liver International

Volume 29 Issue 2, Pages 242 - 247

Published Online: 10 Jul 2008

CLINICAL STUDIES

Non-invasive assessment of liver fibrosis by stiffness measurement in patients

with chronic hepatitis B

Marcellin 1 , nne Ziol 2,3 , Pierre Bedossa 4 , Douvin 5

, Raoul Poupon 6 , Victor de Lédinghen 7 and Michel Beaugrand 8,9

1 Service d'Hépatologie and INSERM U 773, Hôpital Beaujon, AP-HP, University

of Paris, Clichy, France

2 UPRES EA 3406, Paris 13 University, Bondy, France

3 Department of Pathology, AP-HP, Verdier Hospital, Bondy, France

4 Department of Pathology, AP-HP, Beaujon Hospital, Clichy, France

5 Department of Hepatology and Gastroenterology, AP-HP, Henri Mondor Hospital,

Créteil, France

6 Department of Hepatology and Gastroenterology, AP-HP, Saint Antoine

Hospital, Paris, France

7 Department of Hepatology and Gastroenterology, Centre d'Investigation de la

Fibrose Hépatique, Haut Lévêque Hospital, Pessac, France

8 UPRES EA 3410, Paris 13 University, Bondy, France

9Department of Hepatology and Gastroenterology, AP-HP, Verdier Hospital,

Bondy, France

Correspondence

Pr Victor de Lédinghen, Department of Hepatology and Gastroenterology, Centre

d'Investigation de la Fibrose Hépatique, Haut Lévêque Hopital, 33604 Pessac,

France

Tel: +33 55 765 6439

Fax: +33 55 765 6445

e-mail: victor.deledinghen@...

ABSTRACT

Background: The need for new non-invasive tools to assess liver fibrosis in

chronic liver diseases has been largely advocated. Liver stiffness measurement

(LSM) using transient elastography (FibroScan®, Echosens™) has been shown to be

correlated to liver fibrosis in various chronic liver diseases. This study aims

to assess its diagnosis accuracy in patients with chronic hepatitis B.

Patients and methods: We prospectively enrolled 202 patients with chronic

hepatitis B in a multicentre study. Patients underwent liver biopsy (LB) and

LSM. METAVIR and Ishak liver fibrosis stages were assessed by two pathologists.

Results: LSM or LB was considered unreliable in 29 patients. Statistical

analysis was conducted in 173 patients. LSM was significantly (P

[Guest guest]

http://www3.interscience.wiley.com/journal/120751070/abstract

Liver International

Volume 29 Issue 2, Pages 242 - 247

Published Online: 10 Jul 2008

CLINICAL STUDIES

Non-invasive assessment of liver fibrosis by stiffness measurement in patients

with chronic hepatitis B

Marcellin 1 , nne Ziol 2,3 , Pierre Bedossa 4 , Douvin 5

, Raoul Poupon 6 , Victor de Lédinghen 7 and Michel Beaugrand 8,9

1 Service d'Hépatologie and INSERM U 773, Hôpital Beaujon, AP-HP, University

of Paris, Clichy, France

2 UPRES EA 3406, Paris 13 University, Bondy, France

3 Department of Pathology, AP-HP, Verdier Hospital, Bondy, France

4 Department of Pathology, AP-HP, Beaujon Hospital, Clichy, France

5 Department of Hepatology and Gastroenterology, AP-HP, Henri Mondor Hospital,

Créteil, France

6 Department of Hepatology and Gastroenterology, AP-HP, Saint Antoine

Hospital, Paris, France

7 Department of Hepatology and Gastroenterology, Centre d'Investigation de la

Fibrose Hépatique, Haut Lévêque Hospital, Pessac, France

8 UPRES EA 3410, Paris 13 University, Bondy, France

9Department of Hepatology and Gastroenterology, AP-HP, Verdier Hospital,

Bondy, France

Correspondence

Pr Victor de Lédinghen, Department of Hepatology and Gastroenterology, Centre

d'Investigation de la Fibrose Hépatique, Haut Lévêque Hopital, 33604 Pessac,

France

Tel: +33 55 765 6439

Fax: +33 55 765 6445

e-mail: victor.deledinghen@...

ABSTRACT

Background: The need for new non-invasive tools to assess liver fibrosis in

chronic liver diseases has been largely advocated. Liver stiffness measurement

(LSM) using transient elastography (FibroScan®, Echosens™) has been shown to be

correlated to liver fibrosis in various chronic liver diseases. This study aims

to assess its diagnosis accuracy in patients with chronic hepatitis B.

Patients and methods: We prospectively enrolled 202 patients with chronic

hepatitis B in a multicentre study. Patients underwent liver biopsy (LB) and

LSM. METAVIR and Ishak liver fibrosis stages were assessed by two pathologists.

Results: LSM or LB was considered unreliable in 29 patients. Statistical

analysis was conducted in 173 patients. LSM was significantly (P