Zinc and the Liver: An Active Interaction

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Zinc and the Liver: An Active Interaction

Authors: Stamoulis, Ioannis; Kouraklis, Grigorios; Theocharis, Stamatios1

Source: Digestive Diseases and Sciences, Volume 52, Number 7, July 2007 ,

pp. 1595-1612(18)

Publisher: Springer

Abstract:

Zinc is an essential trace element, exerting important antioxidant,

anti-inflammatory, and antiapoptotic effects. It affects growth and

development and participates in processes such as aging and cancer

induction. The liver is important for the regulation of zinc homeostasis,

while zinc is necessary for proper liver function. Decreased zinc levels

have been implicated in both acute and chronic liver disease states, and

zinc deficiency has been implicated in the pathogenesis of liver diseases.

Zinc supplementation offers protection in experimental animal models of

acute and chronic liver injury, but these hepatoprotective properties have

not been fully elucidated. In the present review, data on zinc homeostasis,

its implication in the pathogenesis of liver diseases, and its effect on

acute and chronic liver diseases are presented. It is concluded that zinc

could protect against liver diseases, although up to now the underlying

pathophysiology of zinc and liver interactions have not been defined.

http://www.ingentaconnect.com/content/klu/ddas/2007/00000052/00000007/00009462;j\

sessionid=1aqnxfyt66x9r.victoria

_________________________________________________________________

http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT_TAGHM_migration_HM\

_mini_pcmag_0507

[Guest guest]

Zinc and the Liver: An Active Interaction

Authors: Stamoulis, Ioannis; Kouraklis, Grigorios; Theocharis, Stamatios1

Source: Digestive Diseases and Sciences, Volume 52, Number 7, July 2007 ,

pp. 1595-1612(18)

Publisher: Springer

Abstract:

Zinc is an essential trace element, exerting important antioxidant,

anti-inflammatory, and antiapoptotic effects. It affects growth and

development and participates in processes such as aging and cancer

induction. The liver is important for the regulation of zinc homeostasis,

while zinc is necessary for proper liver function. Decreased zinc levels

have been implicated in both acute and chronic liver disease states, and

zinc deficiency has been implicated in the pathogenesis of liver diseases.

Zinc supplementation offers protection in experimental animal models of

acute and chronic liver injury, but these hepatoprotective properties have

not been fully elucidated. In the present review, data on zinc homeostasis,

its implication in the pathogenesis of liver diseases, and its effect on

acute and chronic liver diseases are presented. It is concluded that zinc

could protect against liver diseases, although up to now the underlying

pathophysiology of zinc and liver interactions have not been defined.

http://www.ingentaconnect.com/content/klu/ddas/2007/00000052/00000007/00009462;j\

sessionid=1aqnxfyt66x9r.victoria

_________________________________________________________________

http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT_TAGHM_migration_HM\

_mini_pcmag_0507