Factors influencing liver disease progression in chronic hepatitis B

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Factors influencing liver disease progression in chronic hepatitis B

Authors: Liaw, Yun-Fan1; Sollano, D.2

Source: Liver International, Volume 26, Supplement 2, December 2006, pp.

23-29(7)

Publisher: Blackwell Publishing

Abstract:

Liaw Y-F, Sollano JD. Factors influencing liver disease progression in

chronic hepatitis B.

Liver International 2006: 26: 23-29.

Chronic hepatitis B virus (HBV) infection is a serious health issue in the

Asia-Pacific region, where most infections are acquired perinatally or

during early childhood and may lead to the development of chronic sequelae

such as liver cirrhosis and hepatocellular carcinoma (HCC). Studies have

identified several host factors (age, gender, immune status) and viral

factors (HBV viral load, genotype, basal core promoter and other naturally

occurring HBV mutations) associated with disease progression. Other factors,

including lifestyle (habitual alcohol consumption, cigarette smoking),

exposure to aflatoxin, and viral superinfection may also influence liver

disease progression in patients with chronic HBV. This review highlights

pertinent data on the factors associated with progressive HBV-related liver

disease in patients with chronic hepatitis B. An enhanced understanding of

factors associated with HBV disease progression may lead to improvements in

the selection of candidates for intervention and overall disease management.

Interventions such as lifestyle changes and antiviral therapy may thus

prevent or reduce disease progression.

Keywords: cirrhosis; HBV DNA; HBV viral load; hepatocellular carcinoma;

prevention

Document Type: Research article

DOI: 10.1111/j.1478-3231.2006.01372.x

Affiliations: 1: Liver Research Unit, Chang Gung University, Taipei, Taiwan,

2: Univerisity of Santo Tomas Hospital, Manila, Philippines

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[Guest guest]

Factors influencing liver disease progression in chronic hepatitis B

Authors: Liaw, Yun-Fan1; Sollano, D.2

Source: Liver International, Volume 26, Supplement 2, December 2006, pp.

23-29(7)

Publisher: Blackwell Publishing

Abstract:

Liaw Y-F, Sollano JD. Factors influencing liver disease progression in

chronic hepatitis B.

Liver International 2006: 26: 23-29.

Chronic hepatitis B virus (HBV) infection is a serious health issue in the

Asia-Pacific region, where most infections are acquired perinatally or

during early childhood and may lead to the development of chronic sequelae

such as liver cirrhosis and hepatocellular carcinoma (HCC). Studies have

identified several host factors (age, gender, immune status) and viral

factors (HBV viral load, genotype, basal core promoter and other naturally

occurring HBV mutations) associated with disease progression. Other factors,

including lifestyle (habitual alcohol consumption, cigarette smoking),

exposure to aflatoxin, and viral superinfection may also influence liver

disease progression in patients with chronic HBV. This review highlights

pertinent data on the factors associated with progressive HBV-related liver

disease in patients with chronic hepatitis B. An enhanced understanding of

factors associated with HBV disease progression may lead to improvements in

the selection of candidates for intervention and overall disease management.

Interventions such as lifestyle changes and antiviral therapy may thus

prevent or reduce disease progression.

Keywords: cirrhosis; HBV DNA; HBV viral load; hepatocellular carcinoma;

prevention

Document Type: Research article

DOI: 10.1111/j.1478-3231.2006.01372.x

Affiliations: 1: Liver Research Unit, Chang Gung University, Taipei, Taiwan,

2: Univerisity of Santo Tomas Hospital, Manila, Philippines

http://www.ingentaconnect.com/content/mksg/liv/2006/00000026/A00201s2/art00004;j\

sessionid=6htdeck49a8de.henrietta

_________________________________________________________________

All-in-one security and maintenance for your PC.  Get a free 90-day trial!

http://clk.atdmt.com/MSN/go/msnnkwlo0050000002msn/direct/01/?href=http://clk.atd\

mt.com/MSN/go/msnnkwlo0050000001msn/direct/01/?href=http://www.windowsonecare.co\

m/?sc_cid=msn_hotmail