Viral Mutations and Genotype B Increase Risk of Liver Failure

[Guest guest]

HBV Advocate Journal Review

Viral Mutations and Genotype B Increase Risk of Liver Failure

Researchers compared the HBV for mutations from patients who had chronic

hepatitis B against those with chronic hepatitis B who experienced acute liver

failure. Neither patient group had signs of cirrhosis.

Researchers reported in the January 2010 issue of the Journal of Viral Hepatitis

that the 75 patients who developed liver failure, without any pre-existing liver

cirrhosis, had a higher incidence of having genotype B than the control group,

and they had a higher rate of basal core promoter and precore mutations (BCP/PC)

in their HBV.

The patients with BCP/PC mutations also had higher rates of HBeAg negativity,

higher ALT and lower HBV DNA levels.

[Guest guest]

HBV Advocate Journal Review

Viral Mutations and Genotype B Increase Risk of Liver Failure

Researchers compared the HBV for mutations from patients who had chronic

hepatitis B against those with chronic hepatitis B who experienced acute liver

failure. Neither patient group had signs of cirrhosis.

Researchers reported in the January 2010 issue of the Journal of Viral Hepatitis

that the 75 patients who developed liver failure, without any pre-existing liver

cirrhosis, had a higher incidence of having genotype B than the control group,

and they had a higher rate of basal core promoter and precore mutations (BCP/PC)

in their HBV.

The patients with BCP/PC mutations also had higher rates of HBeAg negativity,

higher ALT and lower HBV DNA levels.