Advanced donor age increases the risk of severe recurrent hepatitis C after live

[Guest guest]

Transplant International

Volume 18 Issue 8 Page 902 - August 2005

doi:10.1111/j.1432-2277.2005.00114.x

ORIGINAL ARTICLE

Advanced donor age increases the risk of severe recurrent hepatitis C after

liver transplantation

Alonso1, Carmelo Loinaz1, Enrique Moreno1, Jiménez1,

Abradelo1, Ramón Gómez1, - Meneu1, Lumbreras2 and Ignacio

García1

Summary

The association between donor age and the severity of recurrent hepatitis C

and, whether there is any donor age above which severity of recurrence

increases significantly, were analyzed. A total of 131 liver grafts of

hepatitis C virus (HCV)-infected recipients were selected for the study.

Distribution of donor age was compared between grafts with and without

severe recurrence. The risk of developing severe recurrence as well as the

hepatitis-free, severe hepatitis-free and HCV-related graft survival was

compared between different donor age groups. Mean donor age was higher for

grafts with severe recurrence (P = 0.007). The risk of developing severe

recurrence within 2 years post-transplant increased with donors aged 50

years (RR = 1.34) and donors aged 70 years (RR = 1.61). Five-year severe

hepatitis-free survival rates decreased progressively when donor age was

over 50 years (P < 0.001). The study shows 50 and 70 years as the donor age

cut-off points above which the evolution of HCV-infected recipients worsens.

[Guest guest]

Transplant International

Volume 18 Issue 8 Page 902 - August 2005

doi:10.1111/j.1432-2277.2005.00114.x

ORIGINAL ARTICLE

Advanced donor age increases the risk of severe recurrent hepatitis C after

liver transplantation

Alonso1, Carmelo Loinaz1, Enrique Moreno1, Jiménez1,

Abradelo1, Ramón Gómez1, - Meneu1, Lumbreras2 and Ignacio

García1

Summary

The association between donor age and the severity of recurrent hepatitis C

and, whether there is any donor age above which severity of recurrence

increases significantly, were analyzed. A total of 131 liver grafts of

hepatitis C virus (HCV)-infected recipients were selected for the study.

Distribution of donor age was compared between grafts with and without

severe recurrence. The risk of developing severe recurrence as well as the

hepatitis-free, severe hepatitis-free and HCV-related graft survival was

compared between different donor age groups. Mean donor age was higher for

grafts with severe recurrence (P = 0.007). The risk of developing severe

recurrence within 2 years post-transplant increased with donors aged 50

years (RR = 1.34) and donors aged 70 years (RR = 1.61). Five-year severe

hepatitis-free survival rates decreased progressively when donor age was

over 50 years (P < 0.001). The study shows 50 and 70 years as the donor age

cut-off points above which the evolution of HCV-infected recipients worsens.