A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese

March 21, 2011

J Infect Dis. 2011 Apr;203(7):943-947.

A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance

in Han Chinese.

An P, Winkler C, Guan L, O'Brien SJ, Zeng Z; the HBV Study Consortium.

Basic Research Laboratory.

Abstract

A recent genome-wide study showed that the single nucleotide polymorphisms

(SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV)

infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for

all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance,

chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T

was strongly associated with decreased risk of chronic HBV infection (odds

ratio, .62; P = .001), consistent with the previous report. We showed for the

first time to our knowledge that it is a predictor for HBV clearance (odds

ratio, 2.41; P < .001). However, rs3077 was not associated with the development

of cirrhosis or hepatocellular carcinoma.

PMID: 21402545 [PubMed - as supplied by publisher]

March 21, 2011