Hepatitis B and C virus co-infections in HIV positive North Indian patients

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World J Gastroenterol 2006 November;12(42):6879-6883

Hepatitis B and C virus co-infections in human immunodeficiency virus

positive North Indian patients

Gupta S, Singh S.

Department of Laboratory Medicine, All India Institute of Medical Sciences,

Ansari Nagar, New Delhi 110029, India. sarman_singh@...

AIM: To determine the prevalence of hepatitis B and C virus infections in

human immunodeficiency virus (HIV) -positive patients at a tertiary care

hospital in New Delhi, India. METHODS: Serum samples from 451 HIV positive

patients were analyzed for HBsAg and HCV antibodies during three years (Jan

2003-Dec 2005). The control group comprised of apparently healthy

bone-marrow and renal donors. RESULTS: The study population comprised

essentially of heterosexually transmitted HIV infection. The prevalence rate

of HBsAg in this population was 5.3% as compared to 1.4% in apparently

healthy donors (P < 0.001). Though prevalence of HCV co-infection (2.43%)

was lower than HBV in this group of HIV positive patients, the prevalence

was significantly higher (P < 0.05) than controls (0.7%). Triple infection

of HIV, HBV and HCV was not detected in any patient. CONCLUSION: Our study

shows a significantly high prevalence of hepatitis virus infections in HIV

infected patients. Hepatitis viruses in HIV may lead to faster progression

to liver cirrhosis and a higher risk of antiretroviral therapy induced

hepatotoxicity. Therefore, it would be advisable to detect hepatitis virus

co-infections in these patients at the earliest.

http://www.wjgnet.com/1007-9327/abstract_en.asp?f=6879 & v=12

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[Guest guest]

World J Gastroenterol 2006 November;12(42):6879-6883

Hepatitis B and C virus co-infections in human immunodeficiency virus

positive North Indian patients

Gupta S, Singh S.

Department of Laboratory Medicine, All India Institute of Medical Sciences,

Ansari Nagar, New Delhi 110029, India. sarman_singh@...

AIM: To determine the prevalence of hepatitis B and C virus infections in

human immunodeficiency virus (HIV) -positive patients at a tertiary care

hospital in New Delhi, India. METHODS: Serum samples from 451 HIV positive

patients were analyzed for HBsAg and HCV antibodies during three years (Jan

2003-Dec 2005). The control group comprised of apparently healthy

bone-marrow and renal donors. RESULTS: The study population comprised

essentially of heterosexually transmitted HIV infection. The prevalence rate

of HBsAg in this population was 5.3% as compared to 1.4% in apparently

healthy donors (P < 0.001). Though prevalence of HCV co-infection (2.43%)

was lower than HBV in this group of HIV positive patients, the prevalence

was significantly higher (P < 0.05) than controls (0.7%). Triple infection

of HIV, HBV and HCV was not detected in any patient. CONCLUSION: Our study

shows a significantly high prevalence of hepatitis virus infections in HIV

infected patients. Hepatitis viruses in HIV may lead to faster progression

to liver cirrhosis and a higher risk of antiretroviral therapy induced

hepatotoxicity. Therefore, it would be advisable to detect hepatitis virus

co-infections in these patients at the earliest.

http://www.wjgnet.com/1007-9327/abstract_en.asp?f=6879 & v=12

_________________________________________________________________

Stay up-to-date with your friends through the Windows Live Spaces friends

list.

http://clk.atdmt.com/MSN/go/msnnkwsp0070000001msn/direct/01/?href=http://spaces.\

live.com/spacesapi.aspx?wx_action=create & wx_url=/friends.aspx & mk