Antifibroticf Effects of Green Tea

[Guest guest]

http://www.sciencedaily.com/releases/2009/11/091118101359.htm

Antifibrotic Effects of Green Tea

ScienceDaily (Nov. 25, 2009) — Several studies have shown that lipid

peroxidation stimulates collagen production in fibroblasts and hepatic stellate

cells (HSC), and plays an important role in the development of liver fibrosis.

Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis

and alcohol induced liver fibrosis were reported in many studies. However, the

hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models

has not been studied.A research article published on November 7, 2009 in the

World Journal of Gastroenterology addresses this question. The research team,

led by Prof. Hong-Yon Cho from Korea University examined the protective effect

of green tea extract (GT) on hepatic fibrosis in a rat HSC line and in a rat

model of DMN-induced hepatic fibrosis.

The results showed GT administration prevented the development of hepatic

fibrosis in the rat model of DMN-induced liver fibrosis. These results were

confirmed both by liver histology and by quantitative measurement of hepatic

hydroxyproline content, a marker of liver collagen deposition. Accordingly,

inhibition of proliferation, reduced collagen deposition, and type 1 collagen

expression were observed in activated HSC-T6 cells following GT treatment. These

results imply that GT reduced the proliferation of activated HSC and down

regulated the collagen content and expression of collagen type 1, thereby

ameliorating hepatic fibrosis.

The researchers drew a conclusion that green tea may protect liver cells and

reduce the deposition of collagen fibers in the liver. Green tea provides a safe

and effective strategy for improving hepatic fibrosis.

--------------------------------------------------------------------------------

Story Source:

Adapted from materials provided by World Journal of Gastroenterology, via

EurekAlert!, a service of AAAS.

--------------------------------------------------------------------------------

Journal Reference:

1.Kim et al. Antifibrotic effects of green tea on in vitro and in vivo models of

liver fibrosis. World Journal of Gastroenterology, 2009; 15 (41): 5200 DOI:

10.3748/wjg.15.5200

[Guest guest]

http://www.sciencedaily.com/releases/2009/11/091118101359.htm

Antifibrotic Effects of Green Tea

ScienceDaily (Nov. 25, 2009) — Several studies have shown that lipid

peroxidation stimulates collagen production in fibroblasts and hepatic stellate

cells (HSC), and plays an important role in the development of liver fibrosis.

Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis

and alcohol induced liver fibrosis were reported in many studies. However, the

hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models

has not been studied.A research article published on November 7, 2009 in the

World Journal of Gastroenterology addresses this question. The research team,

led by Prof. Hong-Yon Cho from Korea University examined the protective effect

of green tea extract (GT) on hepatic fibrosis in a rat HSC line and in a rat

model of DMN-induced hepatic fibrosis.

The results showed GT administration prevented the development of hepatic

fibrosis in the rat model of DMN-induced liver fibrosis. These results were

confirmed both by liver histology and by quantitative measurement of hepatic

hydroxyproline content, a marker of liver collagen deposition. Accordingly,

inhibition of proliferation, reduced collagen deposition, and type 1 collagen

expression were observed in activated HSC-T6 cells following GT treatment. These

results imply that GT reduced the proliferation of activated HSC and down

regulated the collagen content and expression of collagen type 1, thereby

ameliorating hepatic fibrosis.

The researchers drew a conclusion that green tea may protect liver cells and

reduce the deposition of collagen fibers in the liver. Green tea provides a safe

and effective strategy for improving hepatic fibrosis.

--------------------------------------------------------------------------------

Story Source:

Adapted from materials provided by World Journal of Gastroenterology, via

EurekAlert!, a service of AAAS.

--------------------------------------------------------------------------------

Journal Reference:

1.Kim et al. Antifibrotic effects of green tea on in vitro and in vivo models of

liver fibrosis. World Journal of Gastroenterology, 2009; 15 (41): 5200 DOI:

10.3748/wjg.15.5200