What are 'true normal' liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South Korea

[Guest guest]

http://www3.interscience.wiley.com/journal/122688756/abstract

Liver International

Volume 30 Issue 2, Pages 268 - 274

Published Online: 19 Nov 2009

CLINICAL STUDIES

What are 'true normal' liver stiffness values using FibroScan®?: a prospective

study in healthy living liver and kidney donors in South Korea

Seung Up Kim 1 , Gi Hong Choi 2,3 * , Woong Kyu Han 4 * , Beom Kyung Kim 1 * ,

Jun Yong Park 1,3,5 , Do Young Kim 1,3,5 , Jin Sub Choi 2,3 , Seung Choul Yang 4

, Eun Hee Choi 6 , Sang Hoon Ahn 1,3,5 , Kwang-Hyub Han 1,3,5 and Chae Yoon Chon

1,3,5

1 Department of Internal Medicine, Yonsei University College of Medicine,

Seoul, Korea

2 Department of Surgery, Yonsei University College of Medicine, Seoul, Korea

3 Liver Cirrhosis Clinical Research Center, Seoul, Korea

4 Department of Urology, Yonsei University College of Medicine, Seoul, Korea

5 Institute of Gastroenterology, Yonsei University College of Medicine, Seoul,

Korea

6 Department of Biostatistics, Yonsei University College of Medicine, Seoul,

Korea

Correspondence

Do Young Kim, Department of Internal Medicine, Yonsei University College of

Medicine, 250 Seongsanno, Sodaemun-gu, Seoul 120-752, Korea

Tel: +82 2 2228 1992

Fax: +82 2 393 6884

e-mail: dyk1025@...

*Contributed equally to this work.

Wiley & Sons A/S

ABSTRACT

Aims: To identify the normal range of liver stiffness (LS) values by recruiting

healthy living liver and kidney donors in South Korea.

Methods: Liver stiffness measurement (LSM) was performed in 69 healthy living

liver and kidney donors who were admitted for transplantation. None of the

subjects suffered from diabetes mellitus, hypertension, hepatitis B virus

infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or

metabolic syndrome.

Results: LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available

liver histology, eight showed normal liver histology and four showed liver

steatosis of <5% of the hepatocytes. The mean age of our study population was

38.9 ± 11.9 years (35 men and 34 women), with a mean LS value of 4.6 ± 0.5 kPa

(range 3.3–5.6 kPa). LS values were not significantly different between men (4.6

± 0.6 kPa) and women (4.5 ± 0.5 kPa, P=0.636), nor were they significantly

different according to age (P=0.851). Using the fifth and 95th percentiles, we

determined the normal range of LS values to be 3.9–5.3 kPa.

Conclusions: We identified the normal range of LS values and found that LS

values were not significantly influenced by age and gender.

--------------------------------------------------------------------------------

Received 22 August 2009

Accepted 21 October 2009

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1478-3231.2009.02172

[Guest guest]

http://www3.interscience.wiley.com/journal/122688756/abstract

Liver International

Volume 30 Issue 2, Pages 268 - 274

Published Online: 19 Nov 2009

CLINICAL STUDIES

What are 'true normal' liver stiffness values using FibroScan®?: a prospective

study in healthy living liver and kidney donors in South Korea

Seung Up Kim 1 , Gi Hong Choi 2,3 * , Woong Kyu Han 4 * , Beom Kyung Kim 1 * ,

Jun Yong Park 1,3,5 , Do Young Kim 1,3,5 , Jin Sub Choi 2,3 , Seung Choul Yang 4

, Eun Hee Choi 6 , Sang Hoon Ahn 1,3,5 , Kwang-Hyub Han 1,3,5 and Chae Yoon Chon

1,3,5

1 Department of Internal Medicine, Yonsei University College of Medicine,

Seoul, Korea

2 Department of Surgery, Yonsei University College of Medicine, Seoul, Korea

3 Liver Cirrhosis Clinical Research Center, Seoul, Korea

4 Department of Urology, Yonsei University College of Medicine, Seoul, Korea

5 Institute of Gastroenterology, Yonsei University College of Medicine, Seoul,

Korea

6 Department of Biostatistics, Yonsei University College of Medicine, Seoul,

Korea

Correspondence

Do Young Kim, Department of Internal Medicine, Yonsei University College of

Medicine, 250 Seongsanno, Sodaemun-gu, Seoul 120-752, Korea

Tel: +82 2 2228 1992

Fax: +82 2 393 6884

e-mail: dyk1025@...

*Contributed equally to this work.

Wiley & Sons A/S

ABSTRACT

Aims: To identify the normal range of liver stiffness (LS) values by recruiting

healthy living liver and kidney donors in South Korea.

Methods: Liver stiffness measurement (LSM) was performed in 69 healthy living

liver and kidney donors who were admitted for transplantation. None of the

subjects suffered from diabetes mellitus, hypertension, hepatitis B virus

infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or

metabolic syndrome.

Results: LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available

liver histology, eight showed normal liver histology and four showed liver

steatosis of <5% of the hepatocytes. The mean age of our study population was

38.9 ± 11.9 years (35 men and 34 women), with a mean LS value of 4.6 ± 0.5 kPa

(range 3.3–5.6 kPa). LS values were not significantly different between men (4.6

± 0.6 kPa) and women (4.5 ± 0.5 kPa, P=0.636), nor were they significantly

different according to age (P=0.851). Using the fifth and 95th percentiles, we

determined the normal range of LS values to be 3.9–5.3 kPa.

Conclusions: We identified the normal range of LS values and found that LS

values were not significantly influenced by age and gender.

--------------------------------------------------------------------------------

Received 22 August 2009

Accepted 21 October 2009

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1478-3231.2009.02172