Immunogenicity and safety of combined intradermal recombinant Hepatitis B with BCG vaccines at birth

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Vaccine. 2007 Dec 7 [Epub ahead of print]

Immunogenicity and safety of combined intradermal recombinant Hepatitis B with

BCG vaccines at birth.

Carniel EF, Morcillo AM, Blotta MH, Da Silva MT, Mazzola TN, MA, Zanolli

ML, Netto AA, Higashi HG, Raw I, Vilela MM.

Center for Investigation in Pediatrics, Pediatrics Department, State University

of Campinas Medical School, Rua Tessália Vieira de Camargo, 126, Campinas, São

o, CEP 13083-887, Brazil.

This randomized, prospective, non-inferiority study aimed to quantify anti-HBs

titers induced by recombinant Hepatitis B vaccine from healthy infants

vaccinated with combined Hepatitis B and Bacillus Calmette-Guérin (BCG) vaccines

(HbsAg 10mug plus BCG suspension 0.1mg) and compare them to titers obtained with

separated vaccines. Infants were immunized at birth either with combined

intradermal (ID) BCG and Hepatitis B or ID BCG alone and intramuscular (IM)

Hepatitis B. Both groups received IM Hepatitis B at 1 and 6 months of age. After

the third dose anti-HBs titers>/=10IU/mL were observed in 99% of vaccinees

and>/=1000IU/mL in 71%. There were no adverse events in both groups. Combination

of HbsAg with BCG as first dose did not modify the profile of the humoral immune

response for Hepatitis B indicating safety and immunogenicity of this vaccine in

newborn.

PMID: 18155811 [PubMed - as supplied by publisher]

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[Guest guest]

Vaccine. 2007 Dec 7 [Epub ahead of print]

Immunogenicity and safety of combined intradermal recombinant Hepatitis B with

BCG vaccines at birth.

Carniel EF, Morcillo AM, Blotta MH, Da Silva MT, Mazzola TN, MA, Zanolli

ML, Netto AA, Higashi HG, Raw I, Vilela MM.

Center for Investigation in Pediatrics, Pediatrics Department, State University

of Campinas Medical School, Rua Tessália Vieira de Camargo, 126, Campinas, São

o, CEP 13083-887, Brazil.

This randomized, prospective, non-inferiority study aimed to quantify anti-HBs

titers induced by recombinant Hepatitis B vaccine from healthy infants

vaccinated with combined Hepatitis B and Bacillus Calmette-Guérin (BCG) vaccines

(HbsAg 10mug plus BCG suspension 0.1mg) and compare them to titers obtained with

separated vaccines. Infants were immunized at birth either with combined

intradermal (ID) BCG and Hepatitis B or ID BCG alone and intramuscular (IM)

Hepatitis B. Both groups received IM Hepatitis B at 1 and 6 months of age. After

the third dose anti-HBs titers>/=10IU/mL were observed in 99% of vaccinees

and>/=1000IU/mL in 71%. There were no adverse events in both groups. Combination

of HbsAg with BCG as first dose did not modify the profile of the humoral immune

response for Hepatitis B indicating safety and immunogenicity of this vaccine in

newborn.

PMID: 18155811 [PubMed - as supplied by publisher]

_________________________________________________________________

Get the power of Windows + Web with the new Windows Live.

http://www.windowslive.com?ocid=TXT_TAGHM_Wave2_powerofwindows_122007