Virus Mania was retrovirus switch found

[Guest guest]

they have no clue what they are talking about or doing

Read Virus Mania: How the Medical Industry Continually Invents Epidemics,

Making Billion-Dollar Profits At Our Expense (Paperback)

http://www.amazon.com/exec/obidos/ISBN=1425114679/wellwithinA/

EXCELLENT book revealing all the lies about viruses and

virology.

Sheri

At 06:49 AM 4/10/2010, you wrote:

TechVert

2010-04-09

A University of British Columbia doctoral candidate has discovered a

previously unknown mechanism for silencing retroviruses, segments of

genetic material that can lead to fatal mutations in a cell’s

DNA.

The findings, published today in the journal Nature, could lead to new

cancer treatments that kill only tumor cells and leave healthy

surrounding tissue unharmed.

Danny Leung, a 27-year-old graduate student in the laboratory of Asst.

Prof. Lorincz in the Dept. of Medical Genetics, UBC Faculty of

Medicine, found that a protein called ESET is crucial to preventing the

activity of endogenous retroviruses in mouse embryonic stem cells.

Distant relatives of such retroviruses are more active in the cells of

testicular, breast and skin cancers in humans.

If ESET can be blocked, retroviruses would become dramatically more

active, thus either killing the cancer cells hosting them or flagging

them as targets for the immune system.

Leung, who was co-lead author with a graduate student at Kyoto University

in Japan, has devoted his studies at UBC to the growing field of

epigenetics – changes to the genome that do not involve changess to the

underlying genetic code. Such changes determine whether or not a gene is

expressed.

The common method for silencing certain genes is DNA methylation, in

which a chemical group attaches to the DNA structure. But Leung and his

collaborators at UBC and Kyoto University found that the activity of ESET

is far more potent than DNA methylation in silencing retroviruses in

embryonic stem cells of mice. This indicates an independent parallel

pathway of silencing the retroviruses.

Their research has direct bearing on cancer treatments because cancer

cells are stem-like – they can differentiate into other types of ceells.

Also, for unknown reasons, cancer cells have significantly less DNA

methylation than normal cells. So blocking ESET holds the promise of

affecting only cancer cells, allowing retroviruses to flourish to the

detriment of their hosts. Normal, differentiated cells, which still have

DNA methylation to keep retroviruses in check, would be

unaffected.

“Inhibiting ESET may affect just the cancer cells, allowing further

expression of retroviruses, which in turn would kill the cancer cells,â€

says Leung, who is in his third year of graduate studies at UBC. His

co-lead author on the paper, Toshiyuki Matsui, is a student in the lab of

Yoichi Shinkai at Kyoto University.

[Guest guest]

they have no clue what they are talking about or doing

Read Virus Mania: How the Medical Industry Continually Invents Epidemics,

Making Billion-Dollar Profits At Our Expense (Paperback)

http://www.amazon.com/exec/obidos/ISBN=1425114679/wellwithinA/

EXCELLENT book revealing all the lies about viruses and

virology.

Sheri

At 06:49 AM 4/10/2010, you wrote:

TechVert

2010-04-09

A University of British Columbia doctoral candidate has discovered a

previously unknown mechanism for silencing retroviruses, segments of

genetic material that can lead to fatal mutations in a cell’s

DNA.

The findings, published today in the journal Nature, could lead to new

cancer treatments that kill only tumor cells and leave healthy

surrounding tissue unharmed.

Danny Leung, a 27-year-old graduate student in the laboratory of Asst.

Prof. Lorincz in the Dept. of Medical Genetics, UBC Faculty of

Medicine, found that a protein called ESET is crucial to preventing the

activity of endogenous retroviruses in mouse embryonic stem cells.

Distant relatives of such retroviruses are more active in the cells of

testicular, breast and skin cancers in humans.

If ESET can be blocked, retroviruses would become dramatically more

active, thus either killing the cancer cells hosting them or flagging

them as targets for the immune system.

Leung, who was co-lead author with a graduate student at Kyoto University

in Japan, has devoted his studies at UBC to the growing field of

epigenetics – changes to the genome that do not involve changess to the

underlying genetic code. Such changes determine whether or not a gene is

expressed.

The common method for silencing certain genes is DNA methylation, in

which a chemical group attaches to the DNA structure. But Leung and his

collaborators at UBC and Kyoto University found that the activity of ESET

is far more potent than DNA methylation in silencing retroviruses in

embryonic stem cells of mice. This indicates an independent parallel

pathway of silencing the retroviruses.

Their research has direct bearing on cancer treatments because cancer

cells are stem-like – they can differentiate into other types of ceells.

Also, for unknown reasons, cancer cells have significantly less DNA

methylation than normal cells. So blocking ESET holds the promise of

affecting only cancer cells, allowing retroviruses to flourish to the

detriment of their hosts. Normal, differentiated cells, which still have

DNA methylation to keep retroviruses in check, would be

unaffected.

“Inhibiting ESET may affect just the cancer cells, allowing further

expression of retroviruses, which in turn would kill the cancer cells,â€

says Leung, who is in his third year of graduate studies at UBC. His

co-lead author on the paper, Toshiyuki Matsui, is a student in the lab of

Yoichi Shinkai at Kyoto University.