Hepatitis B virus transmission pattern and vaccination efficiency in Uzbekistan

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J Med Virol. 2008 Feb;80(2):217-24.

Hepatitis B virus transmission pattern and vaccination efficiency in Uzbekistan.

Avazova D, Kurbanov F, Tanaka Y, Sugiyama M, Radchenko I, Ruziev D, Musabaev E,

Mizokami M.

National Reference Laboratory, Ministry of Public Health, Tashkent, Uzbekistan.

A national program of universal vaccination for the prevention of chronic

hepatitis B virus (HBV) infection was launched in Uzbekistan since 1998. To

evaluate the 6 years' outcome of the program, 567 children were enrolled in the

study. Among those enrolled, 333 had immunized with adw2 type based Engerix-B

(Glaxo Kline Beechem, Rixensart, Belgium) and 48 with adr type based

Hepavax-Gene (Green Cross Vaccine Corporation, Korea). A cohort of 186 children

born before the immunization program, was also included in the study. When 45

vaccinated children were compared to age/sex-matched 45 unvaccinated children,

the sero-prevalence of HBsAg was 0 versus 11% (P = 0.56), and of anti-HBc was 0%

versus 44% (P < 0.0001), respectively. Loss of anti-HBs was observed in 18.4%

after 5 years. Among 13 HBsAg carriers found in this study, genotype HBV/D was

found in 69%, HBV/A in 23% (all in unvaccinated group) and HBV/C in 8% (in

vaccinated group). No significant differences were observed in this study

between groups which received different vaccine formulation. Phylogenetic

analysis of the HBV isolates obtained from family members of the HBsAg-positive

children, revealed evidence suggesting that transmission in the vaccinated group

was exclusively perinatal, whereas in the unvaccinated group horizontal

transmission pattern predominated. In conclusion, HBV universal vaccination is

efficient in Uzbekistan irrespective of the vaccine formulation used, because

the horizontal transmission pattern predominates currently in this endemic

region. J. Med. Virol. 80:217-224, 2008. © 2007 Wiley-Liss, Inc.

PMID: 18098129 [PubMed - in process]

_________________________________________________________________

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[Guest guest]

J Med Virol. 2008 Feb;80(2):217-24.

Hepatitis B virus transmission pattern and vaccination efficiency in Uzbekistan.

Avazova D, Kurbanov F, Tanaka Y, Sugiyama M, Radchenko I, Ruziev D, Musabaev E,

Mizokami M.

National Reference Laboratory, Ministry of Public Health, Tashkent, Uzbekistan.

A national program of universal vaccination for the prevention of chronic

hepatitis B virus (HBV) infection was launched in Uzbekistan since 1998. To

evaluate the 6 years' outcome of the program, 567 children were enrolled in the

study. Among those enrolled, 333 had immunized with adw2 type based Engerix-B

(Glaxo Kline Beechem, Rixensart, Belgium) and 48 with adr type based

Hepavax-Gene (Green Cross Vaccine Corporation, Korea). A cohort of 186 children

born before the immunization program, was also included in the study. When 45

vaccinated children were compared to age/sex-matched 45 unvaccinated children,

the sero-prevalence of HBsAg was 0 versus 11% (P = 0.56), and of anti-HBc was 0%

versus 44% (P < 0.0001), respectively. Loss of anti-HBs was observed in 18.4%

after 5 years. Among 13 HBsAg carriers found in this study, genotype HBV/D was

found in 69%, HBV/A in 23% (all in unvaccinated group) and HBV/C in 8% (in

vaccinated group). No significant differences were observed in this study

between groups which received different vaccine formulation. Phylogenetic

analysis of the HBV isolates obtained from family members of the HBsAg-positive

children, revealed evidence suggesting that transmission in the vaccinated group

was exclusively perinatal, whereas in the unvaccinated group horizontal

transmission pattern predominated. In conclusion, HBV universal vaccination is

efficient in Uzbekistan irrespective of the vaccine formulation used, because

the horizontal transmission pattern predominates currently in this endemic

region. J. Med. Virol. 80:217-224, 2008. © 2007 Wiley-Liss, Inc.

PMID: 18098129 [PubMed - in process]

_________________________________________________________________

Share life as it happens with the new Windows Live.

http://www.windowslive.com/share.html?ocid=TXT_TAGHM_Wave2_sharelife_122007