Risk of hepatitis B virus transmission from hepatitis B core antibody-positive liver donors

[Guest guest]

Risk of hepatitis B virus transmission from hepatitis B core

antibody-positive liver donors

Bárcena Marugána S. García Garzóna A. López San Romána E. Peña

Gonzáleza R. Nashaa R. Férnandez Muñozb M. Mateosb A. García Plazac

aGastroenterología. Hospital Ramón y Cajal. Madrid.

bMicrobiología y Virología. Hospital Ramón y Cajal. Madrid.

cGastroenterología. Hospital Ramón y Cajal. Madrid.

Background: To study the hepatitis B virus (HBV) transmission from donors

HBsAg­/AntiHBc+ to liver transplant recipients.

Patients and method: We studied retrospectively the HBV serological markers

in 43 donors from our center and also the serological condition of the 41

recipients. The HBV serological markers were analyzed by ELISA and HBV DNA

was detected by hybridation assays.

Results: 13 donors samples showed some HBV serological markers: 6 anti-HBc

and anti- HBs (13.9%), 4 anti-HBc (9%) and 3 anti- HBs (6.9%). There were no

cases of hepatitis B among liver recipients from donors with negative

serological markers. Among the 13 recipients with HBV serological markers, 9

were followed during 39 (SD 17) months. The 5 recipients with no HBV

markers, who received an anti- HBc+ with or without anti- HBs (100%)

developed hepatitis B. The two liver recipients with anti-HBs solely, did

not developed infection (0%). Of the 41 recipients, 15 had some HBV markers

before transplant and two of them received an anti-HBc+ and did not develop

the infection (0%).

Conclusions: In our study, the prevalence of serological HBV infection in

donors and recipients was of 30.2 and 31.7%, respectively. Anti-HBc with or

without anti-HBs donors transmitted the HBV infection in all the cases

(100%) to the susceptible recipients. The presence of anti-HBs in recipients

protected these against the infection. Only the anti-HBs positive donors did

not trasmit the HBV infection.

Keywords: Hepatitis B. Liver transplant. Anti-HBc. Anti-HBs. Donors.

Recipients. Transmission.

Med Clin (Barc) 2001; 116: 125-128

[Guest guest]

Risk of hepatitis B virus transmission from hepatitis B core

antibody-positive liver donors

Bárcena Marugána S. García Garzóna A. López San Romána E. Peña

Gonzáleza R. Nashaa R. Férnandez Muñozb M. Mateosb A. García Plazac

aGastroenterología. Hospital Ramón y Cajal. Madrid.

bMicrobiología y Virología. Hospital Ramón y Cajal. Madrid.

cGastroenterología. Hospital Ramón y Cajal. Madrid.

Background: To study the hepatitis B virus (HBV) transmission from donors

HBsAg­/AntiHBc+ to liver transplant recipients.

Patients and method: We studied retrospectively the HBV serological markers

in 43 donors from our center and also the serological condition of the 41

recipients. The HBV serological markers were analyzed by ELISA and HBV DNA

was detected by hybridation assays.

Results: 13 donors samples showed some HBV serological markers: 6 anti-HBc

and anti- HBs (13.9%), 4 anti-HBc (9%) and 3 anti- HBs (6.9%). There were no

cases of hepatitis B among liver recipients from donors with negative

serological markers. Among the 13 recipients with HBV serological markers, 9

were followed during 39 (SD 17) months. The 5 recipients with no HBV

markers, who received an anti- HBc+ with or without anti- HBs (100%)

developed hepatitis B. The two liver recipients with anti-HBs solely, did

not developed infection (0%). Of the 41 recipients, 15 had some HBV markers

before transplant and two of them received an anti-HBc+ and did not develop

the infection (0%).

Conclusions: In our study, the prevalence of serological HBV infection in

donors and recipients was of 30.2 and 31.7%, respectively. Anti-HBc with or

without anti-HBs donors transmitted the HBV infection in all the cases

(100%) to the susceptible recipients. The presence of anti-HBs in recipients

protected these against the infection. Only the anti-HBs positive donors did

not trasmit the HBV infection.

Keywords: Hepatitis B. Liver transplant. Anti-HBc. Anti-HBs. Donors.

Recipients. Transmission.

Med Clin (Barc) 2001; 116: 125-128