Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated with aspartate amino

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Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated

with aspartate aminotransferase

Authors: Souza dos Santos, ne M.1; de Bem, Andreza F.1; Colpo, Elisângela1;

Bertoncello, Iara1; Nogueira, Cristina W.1; Rocha, João B. T.1

Source: Liver International, Volume 28, Number 1, January 2008 , pp. 54-60(7)

Publisher: Blackwell Publishing

Abstract:

Objectives:

To evaluate the possible relationship between aminotransferases levels and

markers of oxidative stress in chronic hepatitis C patients. Design and methods:

Patients without treatment for hepatitis were divided in to group I

(15-39 U/L); group II (41-76 U/L) and group III (81-311 U/L) of activity

alanine aminotransferase (ALT). Blood markers of oxidative stress [catalase

(CAT), glutathione peroxidase (GPx), thiobarbituric acid-reactive species

(TBARS), nonprotein and protein thiol (NP-SH and P-SH) groups and vitamin C]

were determined. Results:

P-SH and NP-SH levels, TBARS, GPx and CAT were not different between groups.

Vitamin C was significantly decreased in groups II (P=0.03) and III (P=0.001)

when compared with group I and correlated negatively with aspartate

aminotransferase (AST; r=−0.29, P=0.042). Conclusion:

Vitamin C levels were negatively associated with AST, suggesting that vitamin C

could be an additional indicator of hepatitis C severity.

Keywords: aminotransferases; antioxidants; hepatitis C; oxidative stress;

vitamin C

Document Type: Research article

DOI: 10.1111/j.1478-3231.2007.01599.x

Affiliations: 1: Departamento de Química, Centro de Ciências Naturais e

Exatas, Universidade Federal de Santa , Santa , RS, Brazil

_________________________________________________________________

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difference.

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[Guest guest]

Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated

with aspartate aminotransferase

Authors: Souza dos Santos, ne M.1; de Bem, Andreza F.1; Colpo, Elisângela1;

Bertoncello, Iara1; Nogueira, Cristina W.1; Rocha, João B. T.1

Source: Liver International, Volume 28, Number 1, January 2008 , pp. 54-60(7)

Publisher: Blackwell Publishing

Abstract:

Objectives:

To evaluate the possible relationship between aminotransferases levels and

markers of oxidative stress in chronic hepatitis C patients. Design and methods:

Patients without treatment for hepatitis were divided in to group I

(15-39 U/L); group II (41-76 U/L) and group III (81-311 U/L) of activity

alanine aminotransferase (ALT). Blood markers of oxidative stress [catalase

(CAT), glutathione peroxidase (GPx), thiobarbituric acid-reactive species

(TBARS), nonprotein and protein thiol (NP-SH and P-SH) groups and vitamin C]

were determined. Results:

P-SH and NP-SH levels, TBARS, GPx and CAT were not different between groups.

Vitamin C was significantly decreased in groups II (P=0.03) and III (P=0.001)

when compared with group I and correlated negatively with aspartate

aminotransferase (AST; r=−0.29, P=0.042). Conclusion:

Vitamin C levels were negatively associated with AST, suggesting that vitamin C

could be an additional indicator of hepatitis C severity.

Keywords: aminotransferases; antioxidants; hepatitis C; oxidative stress;

vitamin C

Document Type: Research article

DOI: 10.1111/j.1478-3231.2007.01599.x

Affiliations: 1: Departamento de Química, Centro de Ciências Naturais e

Exatas, Universidade Federal de Santa , Santa , RS, Brazil

_________________________________________________________________

i’m is proud to present Cause Effect, a series about real people making a

difference.

http://im.live.com/Messenger/IM/MTV/?source=text_Cause_Effect