Investigation on correlation between expression of CD58 molecule and severity of

[Guest guest]

World J Gastroenterol 2006 July;12(26):4237-4240

Investigation on correlation between expression of CD58 molecule and

severity of hepatitis B

Sheng L, Li J, Qi BT, Ji YQ, Meng ZJ, Xie M.

Department of Pathogenic Microbiology and Immunology, Medical School of

Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

xieming@...

AIM: To investigate the correlation between expression of CD58 and severity

of hepatitis B. METHODS: The level of soluble CD58 (sCD58) in serum of

patients with hepatitis B was detected by enzyme-linked immunosorbent assay.

The level of expression of membrane CD58 molecule in PBMC was detected by

direct immunofluorescence. The levels of serumal TBIL, DBIL, IBIL, ALT and

AST were detected by the automated biochemistry analyzer as well. RESULTS:

The levels of sCD58 in serum and membrane CD58 molecule in PBMC of patients

with hepatitis B were significantly higher than that in normal controls (P <

0.05). Level of CD58 was related to the levels of serumal TBIL, DBIL, IBIL,

ALT and AST. CONCLUSION: The level of CD58 molecule (in both serum and PBMC

form) of patients with hepatitis B is related to the degree of liver damage.

_________________________________________________________________

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[Guest guest]

World J Gastroenterol 2006 July;12(26):4237-4240

Investigation on correlation between expression of CD58 molecule and

severity of hepatitis B

Sheng L, Li J, Qi BT, Ji YQ, Meng ZJ, Xie M.

Department of Pathogenic Microbiology and Immunology, Medical School of

Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

xieming@...

AIM: To investigate the correlation between expression of CD58 and severity

of hepatitis B. METHODS: The level of soluble CD58 (sCD58) in serum of

patients with hepatitis B was detected by enzyme-linked immunosorbent assay.

The level of expression of membrane CD58 molecule in PBMC was detected by

direct immunofluorescence. The levels of serumal TBIL, DBIL, IBIL, ALT and

AST were detected by the automated biochemistry analyzer as well. RESULTS:

The levels of sCD58 in serum and membrane CD58 molecule in PBMC of patients

with hepatitis B were significantly higher than that in normal controls (P <

0.05). Level of CD58 was related to the levels of serumal TBIL, DBIL, IBIL,

ALT and AST. CONCLUSION: The level of CD58 molecule (in both serum and PBMC

form) of patients with hepatitis B is related to the degree of liver damage.

_________________________________________________________________

On the road to retirement? Check out MSN Life Events for advice on how to

get there! http://lifeevents.msn.com/category.aspx?cid=Retirement