Susceptibility to active decompensated cirrhosis is associated with polymorphisms of intercellular a

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Journal of Viral Hepatitis (OnlineEarly Articles).

doi:10.1111/j.1365-2893.2007.00931.x

Abstract

Susceptibility to active decompensated cirrhosis is associated with

polymorphisms of intercellular adhesion molecule-1 (ICAM-1) in chronic HBV

carriers

X.Q. Zhang, X.J. Hong and X.J. BaiDepartment of Infectious Diseases, Southwest

Hospital, Chongqing, P. R. China 400038

X.Q. Zhang, Department of Infectious disease, Southwest Hospital, Chongqing,

P.R. China 400038. E-mail: xuqing651005@...

Abstract

Summary. Intercellular adhesion molecule-1 (ICAM-1) plays an important role in

the pathogenesis of viral hepatitis B. Several inflammatory diseases are

associated with distinct polymorphisms of the ICAM-1 gene. The aims of this

study were to analyse the association of ICAM-1 polymorphisms G241R and K469E

with susceptibility to active decompensated cirrhosis in chronic hepatitis B

virus (HBV) carriers. The polymorphisms at codons G241R and K469E of ICAM-1 were

analysed by sequence-specific primer polymerase chain reaction (PCR-SSP) in 572

unrelated chronic HBV carriers and 157 unrelated healthy HBV non-infected blood

donors. There were significantly increased frequencies of R at codon 241 and E

at codon 469 in patients with active decompensated cirrhosis (38.3% and 58.3%),

compared with patients with chronic hepatitis B (CHB; 21.9% and 46.5%) and

chronic asymptomatic HBV carriers (AsC; 12.6% and 40.3%). The frequencies of

R241-E469 haplotype and genotypes carrying at least one R241-E469 haplotype were

significantly higher in patients with active decompensated cirrhosis than those

in patients with CHB (38.3% and 63.3%vs 21.9% and 36.7%), and significantly

higher in patients with CHB than those in AsC (21.9% and 36.7%vs 12.6% and

23.3%). The ICAM-1 polymorphisms at codons G241R and E469K were associated with

the disease susceptibility, and susceptibility to active decompensated cirrhosis

is significantly increased in chronic HBV carriers carrying at least one

R241-E469 haplotype.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2893.2007.00931.x

_________________________________________________________________

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[Guest guest]

Journal of Viral Hepatitis (OnlineEarly Articles).

doi:10.1111/j.1365-2893.2007.00931.x

Abstract

Susceptibility to active decompensated cirrhosis is associated with

polymorphisms of intercellular adhesion molecule-1 (ICAM-1) in chronic HBV

carriers

X.Q. Zhang, X.J. Hong and X.J. BaiDepartment of Infectious Diseases, Southwest

Hospital, Chongqing, P. R. China 400038

X.Q. Zhang, Department of Infectious disease, Southwest Hospital, Chongqing,

P.R. China 400038. E-mail: xuqing651005@...

Abstract

Summary. Intercellular adhesion molecule-1 (ICAM-1) plays an important role in

the pathogenesis of viral hepatitis B. Several inflammatory diseases are

associated with distinct polymorphisms of the ICAM-1 gene. The aims of this

study were to analyse the association of ICAM-1 polymorphisms G241R and K469E

with susceptibility to active decompensated cirrhosis in chronic hepatitis B

virus (HBV) carriers. The polymorphisms at codons G241R and K469E of ICAM-1 were

analysed by sequence-specific primer polymerase chain reaction (PCR-SSP) in 572

unrelated chronic HBV carriers and 157 unrelated healthy HBV non-infected blood

donors. There were significantly increased frequencies of R at codon 241 and E

at codon 469 in patients with active decompensated cirrhosis (38.3% and 58.3%),

compared with patients with chronic hepatitis B (CHB; 21.9% and 46.5%) and

chronic asymptomatic HBV carriers (AsC; 12.6% and 40.3%). The frequencies of

R241-E469 haplotype and genotypes carrying at least one R241-E469 haplotype were

significantly higher in patients with active decompensated cirrhosis than those

in patients with CHB (38.3% and 63.3%vs 21.9% and 36.7%), and significantly

higher in patients with CHB than those in AsC (21.9% and 36.7%vs 12.6% and

23.3%). The ICAM-1 polymorphisms at codons G241R and E469K were associated with

the disease susceptibility, and susceptibility to active decompensated cirrhosis

is significantly increased in chronic HBV carriers carrying at least one

R241-E469 haplotype.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2893.2007.00931.x

_________________________________________________________________

The best games are on Xbox 360. Click here for a special offer on an Xbox 360

Console.

http://www.xbox.com/en-US/hardware/wheretobuy/